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A general class of stochastic gene expression models with self regulation is considered. One or more genes randomly switch between regulatory states, each having a different mRNA transcription rate. The gene or genes are self regulating…

Molecular Networks · Quantitative Biology 2014-12-30 Jay Newby

We introduce a framework for the control of discrete-time switched stochastic systems with uncertain distributions. In particular, we consider stochastic dynamics with additive noise whose distribution lies in an ambiguity set of…

Systems and Control · Electrical Eng. & Systems 2024-05-21 Ibon Gracia , Dimitris Boskos , Morteza Lahijanian , Luca Laurenti , Manuel Mazo

Many enhanced sampling techniques rely on the identification of a number of collective variables that describe all the slow modes of the system. By constructing a bias potential in this reduced space one is then able to sample efficiently…

Computational Physics · Physics 2019-03-05 Michele Invernizzi , Michele Parrinello

We consider a reduced order model of an air-breathing hypersonic engine with a time-dependent stochastic inflow that may cause the failure of the engine. The probability of failure is analyzed by the Freidlin-Wentzell theory, the large…

Probability · Mathematics 2012-08-27 George Papanicolaou , Nicholas West , Tzu-Wei Yang

We show that the thermodynamic limit of a bistable phosphorylation-dephosphorylation cycle has a selection rule for the "more stable" macroscopic steady state. The analysis is akin to the Maxwell construction. Based on the chemical master…

Chemical Physics · Physics 2010-05-28 Hao Ge , Hong Qian

Measurements on real traffic have revealed the existence of metastable states with very high flow. Such states have not been observed in the Nagel-Schreckenberg (NaSch) model which is the basic cellular automaton for the description of…

Statistical Mechanics · Physics 2009-10-31 R. Barlovic , L. Santen , A. Schadschneider , M. Schreckenberg

Random metastability occurs when an externally forced or noisy system possesses more than one state of apparent equilibrium. This work investigates fluctuations in a class of random dynamical systems, arising from randomly perturbing a…

Dynamical Systems · Mathematics 2025-05-30 Cecilia González-Tokman , Joshua Peters

We investigate a simple network, which has a branching-merging structure, using the totally asymmetric simple exclusion process, considering conflicts at the merging point. For both periodic and open boundary conditions, the system exhibits…

Statistical Mechanics · Physics 2023-10-05 Hiroki Yamamoto , Daichi Yanagisawa , Katsuhiro Nishinari

Two models of loss networks, introduced by Gibbens et al. and by Antunes et al., are known to exhibit a mean field limiting regime with several stable equilibria. These models are reexamined in the light of Freidlin and Wentzell's large…

Probability · Mathematics 2010-08-03 D. Tibi

We propose two different macroscopic dynamics to describe the decay of metastable phases in many-particle systems with local interactions. These dynamics depend on the macroscopic order parameter $m$ through the restricted free energy…

Condensed Matter · Physics 2016-08-31 J. Lee , M. A. Novotny , P. A. Rikvold

In this review, an outline of the so called Freidlin-Wentzell theory and its recent extensions is given. Broadly, this theory studies the exponential rate at which the probabilities of rare events related to random perturbation of ODE…

Probability · Mathematics 2014-06-24 Sergio A. Almada Monter

The eigenvalue problem for the dressed bound-state of unstable multilevel systems is examined both outside and inside the continuum, based on the N-level Friedrichs model which describes the couplings between the discrete levels and the…

Quantum Physics · Physics 2009-11-11 Manabu Miyamoto

The main contribution of the current study is two-fold. First, we investigate the energy landscape of the Ising and Potts models on finite two-dimensional lattices without external fields in the low temperature regime. The complete analysis…

Probability · Mathematics 2023-01-05 Seonwoo Kim , Insuk Seo

For most stochastic dynamical systems, variables which are tightly regulated tend to respond slowly to external changes. This idea is often discussed for applicable systems, within a linear response regime, through the Fluctuation…

General Physics · Physics 2017-11-15 Nash Rochman , Sean X. Sun

We investigate the metastable behavior of the long-range Ising model on random regular graphs under Glauber dynamics at low-temperature. We estimate the energy barrier and exit time from the metastable state using a nontrivial path-wise…

Probability · Mathematics 2025-09-03 Vanessa Jacquier

We consider the rate of transition for a particle between two metastable states coupled to a thermal environment for various magnitudes of the coupling strength, using the recently proposed infrequent metadynamics approach (Tiwary and…

Soft Condensed Matter · Physics 2016-05-04 Pratyush Tiwary , B. J. Berne

The metastable behavior of a kinetic Ising--like ferromagnetic model system in which a generic type of microscopic disorder induces nonequilibrium steady states is studied by computer simulation and a mean--field approach. We pay attention,…

Statistical Mechanics · Physics 2009-11-10 P. I. Hurtado , J. Marro , P. L. Garrido

We study the dynamics of (synchronous) one-dimensional cellular automata with cyclical boundary conditions that evolve according to the majority rule with radius $ r $. We introduce a notion that we term cell stability with which we express…

Discrete Mathematics · Computer Science 2022-06-06 Yonatan Nakar , Dana Ron

We study random transitions between two metastable states that appear below a critical temperature in a one dimensional self-gravitating Brownian gas with a modified Poisson equation experiencing a second order phase transition from a…

Statistical Mechanics · Physics 2014-04-23 P. H. Chavanis , L. Delfini

Liquid-gas phase coexistence in a boundary-driven diffusive system is studied by analyzing fluctuating hydrodynamics of a density field defined on a one-dimensional lattice with a space interval $\Lambda$. When an interface width $\ell$ is…

Statistical Mechanics · Physics 2024-11-28 Shin-ichi Sasa , Naoko Nakagawa