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It is well-known that claims coming from observational studies often fail to replicate when rigorously re-tested. The technical problems include multiple testing, multiple modeling and bias. Any or all of these problems can give rise to…

Applications · Statistics 2015-04-09 S. Stanley Young , Robert L. Obenchain , Christophe Lambert

The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of…

Methodology · Statistics 2024-10-16 Heejong Bong , Valérie Ventura , Larry Wasserman

Lung cancer remains one of the leading causes of cancer-related mortality, yet most survival models rely only on baseline factors and overlook posttreatment variables that reflect disease progression. To address this gap, we applied Cox…

Applications · Statistics 2025-10-03 Varun Vishwanathan Nair , Victor Miranda Soberanis

Identifying leading measurement units from a large collection is a common inference task in various domains of large-scale inference. Testing approaches, which measure evidence against a null hypothesis rather than effect magnitude, tend to…

Methodology · Statistics 2020-11-17 Nicholas C. Henderson , Michael A. Newton

This article studies Bayesian model averaging (BMA) in the context of competing expensive computer models in a typical nuclear physics setup. While it is well known that BMA accounts for the additional uncertainty of the model itself, we…

Methodology · Statistics 2019-08-26 Vojtech Kejzlar , Léo Neufcourt , Taps Maiti , Frederi Viens

While death rates due to diseases of the heart have experienced a sharp decline over the past 50 years, these diseases continue to be the leading cause of death in the United States, and the rate of decline varies by geographic location,…

Methodology · Statistics 2018-01-23 Harrison Quick , Lance A. Waller , Michele Casper

For normal canonical models, and more generally a vast array of general spherically symmetric location-scale models with a residual vector, we consider estimating the (univariate) location parameter when it is lower bounded. We provide…

Statistics Theory · Mathematics 2012-07-24 Mohammad Jafari Jozani , Eric Marchand , William Strawderman

A two-stage normal hierarchical model called the Fay--Herriot model and the empirical Bayes estimator are widely used to provide indirect and model-based estimates of means in small areas. However, the performance of the empirical Bayes…

Methodology · Statistics 2019-08-26 Shonosuke Sugasawa

Relative survival represents the preferred framework for the analysis of population cancer survival data. The aim is to model the survival probability associated to cancer in the absence of information about the cause of death. Recent data…

Benchmarking estimation and its risk evaluation is a practically important issue in small area estimation. While Bayesian methods have been widely adopted in small area estimation, existing benchmarking approaches are often ad-hoc, such as…

Methodology · Statistics 2025-09-22 Shonosuke Sugasawa , Genya Kobayashi , Yuki Kawakubo

A local projection model is defined by a set of linear regressions that account for the associations between exogenous variables and an endogenous variable observed at different time points. While it is standard practice to separately…

Methodology · Statistics 2020-07-14 Masahiro Tanaka

In public health, it is critical for policymakers to assess the relationship between the disease prevalence and associated risk factors or clinical characteristics, facilitating effective resources allocation. However, for diseases like…

The empirical Bayes estimators in mixed models are useful for small area estimation in the sense of increasing precision of prediction for small area means, and one wants to know the prediction errors of the empirical Bayes estimators based…

Methodology · Statistics 2016-04-07 Shonosuke Sugasawa , Tatsuya Kubokawa

Two-stage hierarchical models have been widely used in small area estimation to produce indirect estimates of areal means. When the areas are treated exchangeably and the model parameters are assumed to be the same over all areas, we might…

Methodology · Statistics 2020-01-10 Shonosuke Sugasawa , Yuki Kawakubo , Kota Ogasawara

Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial…

Methodology · Statistics 2013-05-24 Duncan Lee , Alastair Rushworth , Sujit K. Sahu

Lung cancer is the leading cause of death among different types of cancers. Every year, the lives lost due to lung cancer exceed those lost to pancreatic, breast, and prostate cancer combined. The survival rate for lung cancer patients is…

Image and Video Processing · Electrical Eng. & Systems 2023-02-17 Saleh Abunajm , Nelly Elsayed , Zag ElSayed , Murat Ozer

This study investigates how different spatiotemporal temperature models affect the estimation of heat-related mortality in Lazio, Italy (2008--2022). First, we compare three methods to reconstruct daily maximum temperature at the…

The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung cancer. Meanwhile, the human mind is limited in effectively handling and fully utilizing the accumulation of such…

Machine Learning · Computer Science 2022-03-29 Yawei Li , Xin Wu , Ping Yang , Guoqian Jiang , Yuan Luo

A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large…

Populations and Evolution · Quantitative Biology 2022-05-19 Roberto Herrero , Dario A. Leon , Augusto Gonzalez

This paper discusses the application of a Bayesian neural network based on the Markov Chain Monte Carlo method in medical image classification with small samples. Experimental results on two medical image datasets, including lung X-ray…

Computation · Statistics 2024-09-20 Mingyu Sun