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Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence…
The paper introduces a biologically and evolutionarily plausible neural architecture that allows a single group of neurons, or an entire cortical pathway, to be dynamically reconfigured to perform multiple, potentially very different…
Neural circuits exhibit remarkable computational flexibility, enabling adaptive responses to noisy and ever-changing environmental cues. A fundamental question in neuroscience concerns how a wide range of behaviors can emerge from a…
During the early developmental process of organisms, the formation of the left-right laterality requires a subtle mechanism, as it is associated with other principal body axes. Any inherent chiral feature in an egg cell can in principal…
Structural plasticity in the brain (i.e. rewiring the connectome) may be viewed as mechanisms for dynamic reconfiguration of neural circuits. First order computations in the brain are done by static neural circuits, whereas higher order…
The structural reorganization of the actin cytoskeleton is facilitated through the action of motor proteins that crosslink the actin filaments and transport them relative to each other. Here, we present a combined experimental-computational…
Bone remodeling is a complex process involving cell-cell interactions, biochemical signaling and mechanical stimuli. Early models of the biological aspects of remodeling were non-spatial and focused on the local dynamics at a fixed location…
Propagation of oscillatory signals through the cortex and coherence is shaped by the connectivity structure of neuronal circuits. This study systematically investigates the network and stimulus properties that shape network responses. The…
Convolutional neural networks (CNNs) have recently emerged as promising models of the ventral visual stream, despite their lack of biological specificity. While current state-of-the-art models of the primary visual cortex (V1) have surfaced…
Humans effortlessly navigate the dynamic visual world, yet deep neural networks (DNNs), despite excelling at many visual tasks, are surprisingly vulnerable to minor image perturbations. Past theories suggest that human visual robustness…
Cellular renewing active matter - assemblies of proliferating and apoptotic cells - underlies tissue homeostasis, morphogenesis, and clonal competition. Previous work in one-dimensional periodic systems identified a fitness advantage…
Activity in coupled systems is often oscillatory, for example, the firing pattern of neuronal populations. Whereas these oscillations have been studied predominantly in local circuits, here we show how the topology of large-scale networks,…
In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…
We use linear stability analysis and hybrid lattice Boltzmann simulations to study the dynamical behaviour of an active nematic confined in a channel made of viscoelastic material. We find that the quiescent, ordered active nematic is…
Collagen remodeling in living tissues exhibits anisotropic orientation patterns commonly described by Von Mises distributions, yet the physical origin of such nonequilibrium organization remains unresolved. In the present work, we…
In conventional deep learning, the number of neurons typically remains fixed during training. However, insights from biology suggest that the human hippocampus undergoes continuous neuron generation and pruning of neurons over the course of…
The grid cells (GCs) of the medial entorhinal cortex (MEC) and place cells (PCs) of the hippocampus are key elements of the brain network for the metric representation of space. Currently, any of the existing theoretical models can explain…
The fields of artificial intelligence and neuroscience have a long history of fertile bi-directional interactions. On the one hand, important inspiration for the development of artificial intelligence systems has come from the study of…
During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not…
This paper presents a theoretical model for studying the dynamics of ordering in alloys which exhibit modulated phases. The model is different from the standard time-dependent Ginzburg-Landau description of the evolution of a non-conserved…