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The spatial context of single-cell gene expression data is crucial for many downstream analyses, yet often remains inaccessible due to practical and technical limitations, restricting the utility of such datasets. In this paper, we propose…

Machine Learning · Computer Science 2025-11-21 Wenbin Zhou , Jin-Hong Du

In this paper, we construct a hierarchical model for spatial compositional data, which is used to reconstruct past land-cover compositions (in terms of coniferous forest, broadleaved forest, and unforested/open land) for five time periods…

Applications · Statistics 2018-04-03 Behnaz Pirzamanbein , Johan Lindström , Anneli Poska , Marie-José Gaillard

Spatial transcriptomics provides an unprecedented perspective for deciphering tissue spatial heterogeneity. However, high-resolution spatial transcriptomic technology remains constrained by limited gene coverage, technical complexity, and…

Biomolecules · Quantitative Biology 2026-05-19 Xinlei Huang , Weihao Dai , Zijun Qin , Xin Yu , Di Wang , Yanran Liu , Lixin Cheng , Xubin Zheng

High-dimensional compositional data, such as those from human microbiome studies, pose unique statistical challenges due to the simplex constraint and excess zeros. While dimension reduction is indispensable for analyzing such data,…

Methodology · Statistics 2025-09-09 Junyoung Park , Cheolwoo Park , Jeongyoun Ahn

We present a new turbulent data reconstruction method with supervised machine learning techniques inspired by super resolution and inbetweening, which can recover high-resolution turbulent flows from grossly coarse flow data in space and…

Fluid Dynamics · Physics 2021-01-25 Kai Fukami , Koji Fukagata , Kunihiko Taira

This work addresses the challenge of using a deep learning model to prune graphs and the ability of this method to integrate explainability into spatio-temporal problems through a new approach. Instead of applying explainability to the…

Machine Learning · Computer Science 2025-10-14 Javier García-Sigüenza , Mirco Nanni , Faraón Llorens-Largo , José F. Vicent

Accurate gene regulatory networks can be used to explain the emergence of different phenotypes, disease mechanisms, and other biological functions. Many methods have been proposed to infer networks from gene expression data but have been…

Quantitative Methods · Quantitative Biology 2018-12-11 Phan Nguyen , Rosemary Braun

Biological systems commonly exhibit complex spatiotemporal patterns whose underlying generative mechanisms pose a significant analytical challenge. Traditional approaches to spatiodynamic inference rely on dimensionality reduction through…

Quantitative Methods · Quantitative Biology 2025-08-01 Jun Won Park , Kangyu Zhao , Sanket Rane

A Bayesian approach is developed to analyze change points in multivariate time series and space-time data. The methodology is used to assess the impact of extended inundation on the ecosystem of the Gulf Plains bioregion in northern…

Methodology · Statistics 2013-06-21 Chris Strickland , Robert Burdett , Robert Denham , Robert Kohn , Kerrie Mengersen

Understanding and predicting microstructure evolution is fundamental to materials science, as it governs the resulting properties and performance of materials. Traditional simulation methods, such as phase-field models, offer high-fidelity…

Machine Learning · Computer Science 2026-02-24 Michael Trimboli , Mohammed Alsubaie , Sirani M. Perera , Ke-Gang Wang , Xianqi Li

We propose a model for hierarchical structured data as an extension to the stochastic temporal convolutional network. The proposed model combines an autoregressive model with a hierarchical variational autoencoder and downsampling to…

Machine Learning · Computer Science 2021-07-02 Carl R. Andersson , Niklas Wahlström , Thomas B. Schön

Data quality is critical to Intelligent Transportation Systems (ITS), as complete and accurate traffic data underpin reliable decision-making in traffic control and management. Recent advances in low-rank tensor recovery algorithms have…

Machine Learning · Computer Science 2025-11-04 Yiyang Yang , Xiejian Chi , Shanxing Gao , Kaidong Wang , Yao Wang

Given a set of synchronous time series, each associated with a sensor-point in space and characterized by inter-series relationships, the problem of spatiotemporal forecasting consists of predicting future observations for each point.…

Machine Learning · Computer Science 2024-06-11 Ivan Marisca , Cesare Alippi , Filippo Maria Bianchi

Modelling the impact of a material's mesostructure on device level performance typically requires access to 3D image data containing all the relevant information to define the geometry of the simulation domain. This image data must include…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Amir Dahari , Steve Kench , Isaac Squires , Samuel J. Cooper

This article proposes a generic framework to process jointly the spatial and spectral information of hyperspectral images. First, sub-images are extracted. Then each of these sub-images follows two parallel workflows, one dedicated to the…

Motivated by the need for computationally tractable spatial methods in neuroimaging studies, we develop a distributed and integrated framework for estimation and inference of Gaussian process model parameters with ultra-high-dimensional…

Methodology · Statistics 2024-02-09 Emily C. Hector , Brian J. Reich , Ani Eloyan

Evolutionary symbolic regression approaches are powerful tools that can approximate an explicit mapping between input features and observation for various problems. However, ensuring that explored expressions maintain consistency with…

Optimization and Control · Mathematics 2024-11-19 Maximilian Reissmann , Yuan Fang , Andrew Ooi , Richard Sandberg

Real-world spatio-temporal data is often incomplete or inaccurate due to various data loading delays. For example, a location-disease-time tensor of case counts can have multiple delayed updates of recent temporal slices for some locations…

Machine Learning · Computer Science 2021-05-13 Cheng Qian , Nikos Kargas , Cao Xiao , Lucas Glass , Nicholas Sidiropoulos , Jimeng Sun

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

Big research efforts have been devoted to efficiently manage spatio-temporal data. However, most works focused on vectorial data, and much less, on raster data. This work presents a new representation for raster data that evolve along time…

Data Structures and Algorithms · Computer Science 2018-10-26 Ana Cerdeira-Pena , Guillermo de Bernardo , Antonio Fariña , Jose R. Parama , Fernando Silva-Coira