Related papers: Solution of the Crow-Kimura and Eigen models for a…
We use a path integral representation to solve the Eigen and Crow-Kimura molecular evolution models for the case of multiple fitness peaks with arbitrary fitness and degradation functions. In the general case, we find that the solution to…
We express the Crow-Kimura and Eigen models of quasispecies theory in a functional integral representation. We formulate the spin coherent state functional integrals using the Schwinger Boson method. In this formulation, we are able to…
In this article we present a new p-adic generalization of the Eigen-Schuster model where the genomes (sequences) are represented by words written in the alphabet 0,1,,p-1, where p is a prime number, with a time variable length. The time…
We review the major progress in the rigorous analysis of the classical quasispecies model that usually comes in two related but different forms: the Eigen model and the Crow--Kimura model. The model itself was formulated almost 50 years…
We reconsider the Eigen's quasi-species model for competing self-reproductive macromolecules in populations characterized by a single-peaked fitness landscape. The use of ideas and tools borrowed from polymers theory and statistical…
A four-state mutation-selection model for the evolution of populations of DNA-sequences is investigated with particular interest in the phenomenon of error thresholds. The mutation model considered is the Kimura 3ST mutation scheme, fitness…
This chapter is an overview of foundational results in the mathematical theory of replicator systems. Its primary aim is to provide a unified framework for the mathematical formalisation of evolutionary processes in the spirit of…
We map Eigen model of biological evolution [Naturwissenschaften {\bf 58}, 465 (1971)] into a one-dimensional quantum spin model with non-Hermitean Hamiltonian. Based on such a connection, we derive exact relaxation periods for the Eigen…
We investigate Eigen's model for the evolution of the genetic code of microorganisms using a novel method based on population dynamics analysis. This model, for a given number of offspring, determines long-term survival as a function of the…
A particular case of the famous quasispecies model - the Crow-Kimura model with a permutation invariant fitness landscape - is investigated. Using the fact that the mutation matrix in the case of a permutation invariant fitness landscape…
The description of number of dual (quasy)-exactly solvable models with its hidden symmetry algebra has been given at different levels of analysis within the framework of generalized Kustaanheimo-Stiefel (KS)-transformations. It's shown that…
We consider a recently proposed nonlinear Schroedinger equation exhibiting soliton-like solutions of the power-law form $e_q^{i(kx-wt)}$, involving the $q$-exponential function which naturally emerges within nonextensive thermostatistics…
K\"ahler's geometric approach in which relativistic fermion fields are treated as differential forms is applied in three spacetime dimensions. It is shown that the resulting continuum theory is invariant under global U($N)\otimes$U($N)$…
We study quartic matrix models with partition function Z[E,J]=\int dM \exp(trace(JM-EM^2-(\lambda/4)M^4)). The integral is over the space of Hermitean NxN-matrices, the external matrix E encodes the dynamics, \lambda>0 is a scalar coupling…
We study the existence of solutions $(\underline u,\lambda_{\underline u})\in H^1(\mathbb{R}^N; \mathbb{R}) \times \mathbb{R}$ to \[ -\Delta u + \lambda u = f(u) \quad \text{in } \mathbb{R}^N \] with $N \ge 3$ and prescribed $L^2$ norm, and…
We present stochastic, finite-population formulations of the Crow-Kimura and Eigen models of quasispecies theory, for fitness functions that depend in an arbitrary way on the number of mutations from the wild type. We include back mutations…
The Einstein-Podolsky-Rosen~(EPR) model is an analogous model of the anti-ferromagnetic Heisenberg model or the equivalent quantum maximum-cut problem, proposed by R. King two years ago. Adjacent qubits in the model prefer symmetric…
We prove the existence of entire solutions with exponential growth for the semilinear elliptic system [\begin{cases} -\Delta u = -u v^2 & \text{in $\R^N$} -\Delta v= -u^2 v & \text{in $\R^N$} u,v>0, \end{cases}] for every $N \ge 2$. Our…
We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…
We present a fast, adaptive multiresolution algorithm for applying integral operators with a wide class of radially symmetric kernels in dimensions one, two and three. This algorithm is made efficient by the use of separated representations…