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The epidemic spreading of a disease can be described by a contact network whose nodes are persons or centers of contagion and links heterogeneous relations among them. We provide a procedure to identify multiple sources of an outbreak or…

Mathematical Physics · Physics 2012-11-13 Vincenzo Fioriti , Marta Chinnici

Early outbreak detection is a key aspect in the containment of infectious diseases, as it enables the identification and isolation of infected individuals before the disease can spread to a larger population. Instead of detecting unexpected…

Machine Learning · Computer Science 2021-10-19 Michael Rapp , Moritz Kulessa , Eneldo Loza Mencía , Johannes Fürnkranz

The ordinal patterns of a fixed number of consecutive values in a time series is the spatial ordering of these values. Counting how often a specific ordinal pattern occurs in a time series provides important insights into the properties of…

Statistics Theory · Mathematics 2025-02-06 Annika Betken , Giorgio Micali , Johannes Schmidt-Hieber

We present the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B. subtilis from experimentally obtained, yet mathematically underdetermined microchip array data. By…

Molecular Networks · Quantitative Biology 2009-11-13 C. Christensen , A. Gupta , C. D. Maranas , R. Albert

We present a model of an olfactory system that performs odor segmentation. Based on the anatomy and physiology of natural olfactory systems, it consists of a pair of coupled modules, bulb and cortex. The bulb encodes the odor inputs as…

Disordered Systems and Neural Networks · Physics 2007-05-23 Zhaoping Li , John Hertz

Rapid identification of bacteria is essential to prevent the spread of infectious disease, help combat antimicrobial resistance, and improve patient outcomes. Raman optical spectroscopy promises to combine bacterial detection,…

We present a new method for detecting and identifying bacteria by measuring impedance fluctuations (impedance noise) caused by ion release by the bacteria during phage infestation. This new method significantly increases the measured signal…

Instrumentation and Detectors · Physics 2014-07-22 Gabor Schmera , Laszlo B. Kish

We report here on the ability of elastic light scattering in discriminating Gram+, Gram-and yeasts at an early stage of growth (6h). Our technique is non-invasive, low cost and does require neither skilled operators nor reagents. Therefore…

Many developmental processes in biology utilize Notch-Delta signaling to construct an ordered pattern of cellular differentiation. This signaling modality is based on nearest-neighbor contact, as opposed to the more familiar mechanism…

Molecular Networks · Quantitative Biology 2020-07-14 Eial Teomy , David A. Kessler , Herbert Levine

Spreadsheet users are often unaware of the risks imposed by poorly designed spreadsheets. One way to assess spreadsheet quality is to detect smells which attempt to identify parts of spreadsheets that are hard to comprehend or maintain and…

Software Engineering · Computer Science 2018-10-11 Patrick Koch , Birgit Hofer , Franz Wotawa

Our sense of smell relies on sensitive, selective atomic-scale processes that are initiated when a scent molecule meets specific receptors in the nose. However, the physical mechanisms of detection are not clear. While odorant shape and…

Biological Physics · Physics 2015-06-26 Jennifer C. Brookes , Filio Hartoutsiou , A. P. Horsfield , A. M. Stoneham

Bacteria are easily characterizable model organisms with an impressively complicated set of capabilities. Among their capabilities is quorum sensing, a detailed cell-cell signaling system that may have a common origin with eukaryotic…

Neurons and Cognition · Quantitative Biology 2017-09-14 Archana Ram , Andrew Lo

Bacteria living on surfaces are often confined to droplets. When these droplets evaporate, the motion of the liquid-air interface and the associated internal capillary flow confine the bacteria. Here we study how \emph{E. coli} bacteria…

A Rapid and cost-effective method for detecting bacterial cells on surfaces is critical to protect public health from various aspects, including food safety, clinical hygiene, and pharmacy quality. Herein, we first established an optical…

Quantitative Methods · Quantitative Biology 2024-03-13 Yuzhen Zhang , Zili Gao , Lili He

Pattern discovery, the process of discovering previously unrecognized patterns, is often performed as an ad-hoc process with little resulting certainty in the quality of the proposed patterns. Pattern validation, the process of validating…

Artificial Intelligence · Computer Science 2021-07-14 Dirk Riehle , Nikolay Harutyunyan , Ann Barcomb

Early, reliable detection of disease outbreaks is a critical problem today. This paper reports an investigation of the use of causal Bayesian networks to model spatio-temporal patterns of a non-contagious disease (respiratory anthrax…

Applications · Statistics 2012-07-19 Gregory F. Cooper , Denver Dash , John Levander , Weng-Keen Wong , William Hogan , Michael Wagner

Design patterns are generalized solutions to frequently recurring problems. They were initially developed by architects and computer scientists to create a higher level of abstraction for their designs. Here, we extend these concepts to…

Molecular Networks · Quantitative Biology 2023-10-13 Steven S. Andrews , H. Steven Wiley , Herbert M. Sauro

An accurate method for enumerating pathogen indicators, such as Escherichia coli (E. coli), and Salmonella spp. is important for assessing the safety of compost samples. This study aimed to determine the occurrence of pathogen indicators in…

Quantitative Methods · Quantitative Biology 2014-04-15 N. M. Sunar , D. I. Stewart , E. I. Stentiford , L. A. Flecther

Sensory systems have evolved to respond to input stimuli of certain statistical properties, and to reliably transmit this information through biochemical pathways. Hence, for an experimentally well-characterized sensory system, one ought to…

Cell Behavior · Quantitative Biology 2014-10-30 Diana Clausznitzer , Gabriele Micali , Silke Neumann , Victor Sourjik , Robert G. Endres

A model of pattern formation in living systems is presented. The pattern is achieved by the sequential interaction of two signaling pathways. The coupling of the pattern to the (thick) epithelial sheet changes is given, when the Gauss…

Tissues and Organs · Quantitative Biology 2009-05-11 Frederick W. Cummings