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Conditional sampling distributions (CSDs), sometimes referred to as copying models, underlie numerous practical tools in population genomic analyses. Though an important application that has received much attention is the inference of…

Populations and Evolution · Quantitative Biology 2015-03-20 Matthias Steinrücken , Joshua S. Paul , Yun S. Song

The development of coalescent theory paved the way to statistical inference from population genetic data. In the genomic era, however, coalescent models are limited due to the complexity of the underlying ancestral recombination graph. The…

Populations and Evolution · Quantitative Biology 2021-06-30 Julien Y. Dutheil

Two sequentially Markov coalescent models (SMC and SMC') are available as tractable approximations to the ancestral recombination graph (ARG). We present a Markov process describing coalescence at two fixed points along a pair of sequences…

Populations and Evolution · Quantitative Biology 2015-03-06 Peter R. Wilton , Shai Carmi , Asger Hobolth

Studying how diverse human populations are related is of historical and anthropological interest, in addition to providing a realistic null model for testing for signatures of natural selection or disease associations. Furthermore,…

Populations and Evolution · Quantitative Biology 2018-07-10 Jeffrey P. Spence , Matthias Steinrücken , Jonathan Terhorst , Yun S. Song

We propose a new algorithm to do posterior sampling of Kingman's coalescent, based upon the Particle Markov Chain Monte Carlo methodology. Specifically, the algorithm is an instantiation of the Particle Gibbs Sampling method, which…

Machine Learning · Statistics 2013-05-07 Yifei Chen , Xiaohui Xie

State-space models are commonly used to describe different forms of ecological data. We consider the case of count data with observation errors. For such data the system process is typically multi-dimensional consisting of coupled Markov…

Methodology · Statistics 2017-08-15 Axel Finke , Ruth King , Alexandros Beskos , Petros Dellaportas

Kingman's coalescent is a widely used process to model sample genealogies in population genetics. Recently there have been studies on the inference of quantities related to the genealogy of additional individuals given a known sample. This…

Probability · Mathematics 2024-02-29 Linglong Yuan

We introduce an individual-based model for structured populations undergoing demographic bottlenecks, i.e. drastic reductions in population size that last many generations and can have arbitrary shapes. We first show that the…

Probability · Mathematics 2025-04-17 Marta Dai Pra , Alison Etheridge , Jere Koskela , Maite Wilke-Berenguer

Genetic recombination is one of the most important mechanisms that can generate and maintain diversity, and recombination information plays an important role in population genetic studies. However, the phenomenon of recombination is…

Statistics Theory · Mathematics 2014-08-29 Xian Chen , Zhi-Ming Ma , Ying Wang

The rapid development of sequencing technologies represents new opportunities for population genetics research. It is expected that genomic data will increase our ability to reconstruct the history of populations. While this increase in…

Populations and Evolution · Quantitative Biology 2014-12-04 Olivier Mazet , Willy Rodríguez , Lounès Chikhi

Consider a continuous-state branching population constructed as a flow of nested subordinators. Inverting the subordinators and reversing time give rise to a flow of coalescing Markov processes (with negative jumps) which correspond to the…

Probability · Mathematics 2018-12-04 Clément Foucart , Chunhua Ma , Bastien Mallein

When an advantageous mutation occurs in a population, the favorable allele may spread to the entire population in a short time, an event known as a selective sweep. As a result, when we sample $n$ individuals from a population and trace…

Probability · Mathematics 2007-05-23 Rick Durrett , Jason Schweinsberg

We show that genealogical trees arising from a broad class of non-neutral models of population evolution converge to the Kingman coalescent under a suitable rescaling of time. As well as non-neutral biological evolution, our results apply…

Probability · Mathematics 2025-04-09 Jere Koskela , Paul A. Jenkins , Adam M. Johansen , Dario Spano

We present simple conditions under which the limiting genealogical process associated with a class of interacting particle systems with non-neutral selection mechanisms, as the number of particles grows, is a time-rescaled Kingman…

Computation · Statistics 2020-12-08 Suzie Brown , Paul A. Jenkins , Adam M. Johansen , Jere Koskela

Inference of the marginal likelihood of sample allele configurations using backward algorithms yields identical results with the Kingman coalescent, the Moran model, and the diffusion model (up to a scaling of time). For inference of…

Populations and Evolution · Quantitative Biology 2021-12-20 Claus Vogl , Sandra Peer , Lynette Caitlin Mikula

Recovery of population size history from molecular sequence data is an important problem in population genetics. Inference commonly relies on a coalescent model linking the population size history to genealogies. The high computational cost…

Statistics Theory · Mathematics 2018-01-17 James E. Johndrow , Julia A. Palacios

In population genetics, extant samples are usually used for inference of past population genetic forces. With the Kingman coalescent and the backward diffusion equation, inference of the marginal likelihood proceeds from an extant sample…

Populations and Evolution · Quantitative Biology 2020-04-03 Claus Vogl , Sandra Peer

Bertoin and Le Gall (2003) introduced a certain probability measure valued Markov process that describes the evolution of a population, such that a sample from this population would exhibit a genealogy given by the so-called…

Probability · Mathematics 2007-05-23 Andreas Nordvall Lagerås

Sweepstakes reproduction may be generated by chance matching of reproduction with favorable environmental conditions. Gene genealogies generated by sweepstakes reproduction are in the domain of attraction of multiple-merger coalescents…

Probability · Mathematics 2026-01-15 Bjarki Eldon

Probability modelling for DNA sequence evolution is well established and provides a rich framework for understanding genetic variation between samples of individuals from one or more populations. We show that both classical and more recent…

Populations and Evolution · Quantitative Biology 2018-06-07 Asger Hobolth , Arno Siri-Jégousse , Mogens Bladt
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