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It is common to reject undesired outputs of Large Language Models (LLMs); however, current methods to do so require an excessive amount of computation to re-sample after a rejection, or distort the distribution of outputs by constraining…

Computation and Language · Computer Science 2025-10-09 Daniel Melcer , Sujan Gonugondla , Pramuditha Perera , Haifeng Qian , Wen-Hao Chiang , Yanjun Wang , Nihal Jain , Pranav Garg , Xiaofei Ma , Anoop Deoras

Large language models demonstrate reasonable multilingual abilities, despite predominantly English-centric pretraining. However, the spontaneous multilingual alignment in these models is shown to be weak, leading to unsatisfactory…

Computation and Language · Computer Science 2024-11-19 Jiahuan Li , Shujian Huang , Aarron Ching , Xinyu Dai , Jiajun Chen

Modern neural networks have greatly improved performance across speech recognition benchmarks. However, gains are often driven by frequent words with limited semantic weight, which can obscure meaningful differences in word error rate, the…

Computation and Language · Computer Science 2026-04-21 Lasse Borgholt , Jakob Havtorn , Christian Igel , Lars Maaløe , Zheng-Hua Tan

Analysis of the sequence-structure relationship in RNA molecules are essential to evolutionary studies but also to concrete applications such as error-correction methodologies in sequencing technologies. The prohibitive sizes of the…

Quantitative Methods · Quantitative Biology 2013-05-31 Vladimir Reinharz , Yann Ponty , Jérôme Waldispühl

A novel approach to protein multiple sequence alignment is discussed: substantially this method counterparts with substitution matrix based methods (like Blosum or PAM based methods), and implies a more deterministic approach to…

Other Quantitative Biology · Quantitative Biology 2007-06-07 Stefano Marino

Seglearn is an open-source python package for machine learning time series or sequences using a sliding window segmentation approach. The implementation provides a flexible pipeline for tackling classification, regression, and forecasting…

Machine Learning · Statistics 2019-01-28 David M. Burns , Cari M. Whyne

Network alignment (NA) aims to identify node correspondence across different networks and serves as a critical cornerstone behind various downstream multi-network learning tasks. Despite growing research in NA, there lacks a comprehensive…

Machine Learning · Computer Science 2026-03-03 Qi Yu , Zhichen Zeng , Yuchen Yan , Zhining Liu , Baoyu Jing , Ruizhong Qiu , Ariful Azad , Hanghang Tong

Alignment algorithms usually rely on simplified models of gaps for computational efficiency. Based on an isomorphism between alignments and physical helix-coil models, we show in statistical mechanics that alignments with realistic laws for…

Genomics · Quantitative Biology 2015-06-26 E. Yeramian , E. Debonneuil

Resampling algorithms are a useful approach to deal with imbalanced learning in multilabel scenarios. These methods have to deal with singularities in the multilabel data, such as the occurrence of frequent and infrequent labels in the same…

Machine Learning · Computer Science 2025-01-22 Antonio J. Rivera , Miguel A. Dávila , David Elizondo , María J. del Jesus , Francisco Charte

DNA sequence alignment is important today as it is usually the first step in finding gene mutation, evolutionary similarities, protein structure, drug development and cancer treatment. Covid-19 is one recent example. There are many…

Genomics · Quantitative Biology 2023-06-01 Suchindra , Preetam Nagaraj

Large Language Models (LLMs) have demonstrated significant capabilities in machine translation. However, their translation quality is sometimes questioned, as the generated outputs may deviate from expressions typically used by native…

Computation and Language · Computer Science 2024-12-10 Ke-Ching Chang , Chung-Chi Chen , An-Zi Yen

High-dimensional data of discrete and skewed nature is commonly encountered in high-throughput sequencing studies. Analyzing the network itself or the interplay between genes in this type of data continues to present many challenges. As…

Methodology · Statistics 2017-12-01 Anjali Silva , Steven J. Rothstein , Paul D. McNicholas , Sanjeena Subedi

The matching of multiple objects (e.g. shapes or images) is a fundamental problem in vision and graphics. In order to robustly handle ambiguities, noise and repetitive patterns in challenging real-world settings, it is essential to take…

Computer Vision and Pattern Recognition · Computer Science 2019-03-15 Florian Bernard , Johan Thunberg , Paul Swoboda , Christian Theobalt

Online alignment in machine translation refers to the task of aligning a target word to a source word when the target sequence has only been partially decoded. Good online alignments facilitate important applications such as lexically…

Computation and Language · Computer Science 2022-04-05 Soumya Chatterjee , Sunita Sarawagi , Preethi Jyothi

In typical machine learning systems, an estimate of the probability of the prediction is used to assess the system's confidence in the prediction. This confidence measure is usually uncalibrated; i.e.\ the system's confidence in the…

Computation and Language · Computer Science 2022-05-24 Shehzaad Dhuliawala , Leonard Adolphs , Rajarshi Das , Mrinmaya Sachan

An important component of any generation system is the mapping dictionary, a lexicon of elementary semantic expressions and corresponding natural language realizations. Typically, labor-intensive knowledge-based methods are used to…

Computation and Language · Computer Science 2007-05-23 Regina Barzilay , Lillian Lee

Historical manuscript alignment is a widely known problem in document analysis. Finding the differences between manuscript editions is mostly done manually. In this paper, we present a writer independent deep learning model which is trained…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Majeed Kassis , Jumana Nassour , Jihad El-Sana

The problem of image registration is finding a transformation that aligns two images, such that the corresponding points are in the same location. This paper introduces a simple, end-to-end trainable algorithm that is implementable in a few…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Stefan Dirnstorfer

Sequences of nucleotides (for DNA and RNA) or amino acids (for proteins) are central objects in biology. Among the most important computational problems is that of sequence alignment, i.e. arranging sequences from different organisms in…

Quantitative Methods · Quantitative Biology 2020-12-08 Anna Paola Muntoni , Andrea Pagnani , Martin Weigt , Francesco Zamponi

Motivated by alignment of correlated sparse random graphs, we introduce a hypothesis testing problem of deciding whether or not two random trees are correlated. We obtain sufficient conditions under which this testing is impossible or…

Data Structures and Algorithms · Computer Science 2024-09-06 Luca Ganassali , Laurent Massoulié , Marc Lelarge