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In a geographically distributed population, assortative clustering plays an important role in evolution by modifying local environments. To examine its effects in a linear habitat, we consider a one-dimensional grid of cells, where each…

Populations and Evolution · Quantitative Biology 2021-03-16 Sunhee Chae , Nahyeon Lee , Seung Ki Baek , Hyeong-Chai Jeong

Most of the DNA that composes a complex organism is non-coding and defined as junk. Even the coding part is composed of genes that affect the phenotype differently. Therefore, a random mutation has an effect on the specimen fitness that…

Populations and Evolution · Quantitative Biology 2021-07-19 Mattia Miotto , Lorenzo Monacelli

In ecology, species can mitigate their extinction risks in uncertain environments by diversifying individual phenotypes. This observation is quantified by the theory of bet-hedging, which provides a reason for the degree of phenotypic…

Populations and Evolution · Quantitative Biology 2019-06-19 Paula Villa Martín , Miguel A. Muñoz , Simone Pigolotti

Genome-wide patterns of genetic divergence reveal mechanisms of adaptation under gene flow. Empirical data show that divergence is mostly concentrated in narrow genomic regions. This pattern may arise because differentiated loci protect…

Populations and Evolution · Quantitative Biology 2017-02-21 M. Rafajlovic , A. Emanuelsson , K. Johannesson , R. K. Butlin , B. Mehlig

Languages and genes are both transmitted from generation to generation, with opportunity for differential reproduction and survivorship of forms. Here we apply a rigorous inference framework, drawn from population genetics, to distinguish…

Populations and Evolution · Quantitative Biology 2017-11-07 Christopher A. Ahern , Mitchell G. Newberry , Robin Clark , Joshua B. Plotkin

Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in…

Populations and Evolution · Quantitative Biology 2018-08-15 Hong-Yan Shih , Harry Mickalide , David T. Fraebel , Nigel Goldenfeld , Seppe Kuehn

We model the competition between recombination and point mutation in microbial genomes, and present evidence for two distinct phases, one uniform, the other genetically diverse. Depending on the specifics of homologous recombination, we…

Genomics · Quantitative Biology 2009-11-11 Kalin Vetsigian , Nigel Goldenfeld

Cooperation is ubiquitous in nature, but explaining its existence remains a central interdisciplinary challenge. Cooperation is most difficult to explain in the Prisoner's Dilemma game, where cooperators always lose in direct competition…

Populations and Evolution · Quantitative Biology 2013-11-13 J. David Van Dyken , Melanie J. I. Muller , Keenan M. L. Mack , Michael M. Desai

Large populations may contain numerous simultaneously segregating polymorphisms subject to natural selection. Since selection acts on individuals whose fitness depends on many loci, different loci affect each other's dynamics. This leads to…

Populations and Evolution · Quantitative Biology 2011-08-09 Richard A. Neher , Boris I. Shraiman

Species sharing a habitat will co-evolve to make use of the available resources, as consumption is modulated by competition and negative feedback loops between consumers and resources. The dietary range of a given species determines the…

Populations and Evolution · Quantitative Biology 2026-05-28 Elliot M. Butterworth , Tim Rogers

Rare evolutionary events, such as the rise to prominence of deleterious mutations, can have drastic impacts on the evolution of growing populations. Heterogeneous environments may reduce the influence of selection on evolutionary outcomes…

Populations and Evolution · Quantitative Biology 2024-10-10 Jimmy Gonzalez Nuñez , Daniel A. Beller

To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare. But if…

Populations and Evolution · Quantitative Biology 2014-03-25 Richard A. Neher

Highly-diverse ecosystems exhibit a broad distribution of population sizes and species turnover, where species at high and low abundances are exchanged over time. We show that these two features generically emerge in the fluctuating phase…

Populations and Evolution · Quantitative Biology 2024-01-09 Thibaut Arnoulx de Pirey , Guy Bunin

The dynamics of two competing species in a finite size community is one of the most studied problems in population genetics and community ecology. Stochastic fluctuations lead, inevitably, to the extinction of one of the species, but the…

Populations and Evolution · Quantitative Biology 2016-11-30 Matan Danino , David A. Kessler , Nadav M. Shnerb

The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise. Selection by individuals' fitness, usually the basic driving…

Populations and Evolution · Quantitative Biology 2009-09-26 Jonas Cremer , Tobias Reichenbach , Erwin Frey

Dispersal of species to find a more favorable habitat is important in population dynamics. Dispersal rates evolve in response to the relative success of different dispersal strategies. In a simplified deterministic treatment (J. Dockery, V.…

Populations and Evolution · Quantitative Biology 2009-07-28 David A. Kessler , Leonard M. Sander

Unraveling the evolutionary forces shaping bacterial diversity can today be tackled using a growing amount of genomic data. While the genome of eukaryotes is highly stable, bacterial genomes from cells of the same species highly vary in…

Populations and Evolution · Quantitative Biology 2015-03-19 Franz Baumdicker , Peter Pfaffelhuber

A major goal of molecular evolutionary biology is to identify loci or regions of the genome under selection versus those evolving in a neutral manner. Correct identification allows accurate inference of the evolutionary process and thus…

Populations and Evolution · Quantitative Biology 2020-06-18 Fanny Pouyet , Kimberly J. Gilbert

Environmental heterogeneity can drive genetic heterogeneity in expanding populations; mutant strains may emerge that trade overall growth rate for an improved ability to survive in patches that are hostile to the wild type. This…

Populations and Evolution · Quantitative Biology 2023-03-06 Thomas Tunstall , Tim Rogers , Wolfram Möbius

There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can…

Populations and Evolution · Quantitative Biology 2023-11-16 Lluís Hernández-Navarro , Matthew Asker , Alastair M. Rucklidge , Mauro Mobilia