Global divergence of microbial genome sequences mediated by propagating fronts
Genomics
2009-11-11 v3
Abstract
We model the competition between recombination and point mutation in microbial genomes, and present evidence for two distinct phases, one uniform, the other genetically diverse. Depending on the specifics of homologous recombination, we find that global sequence divergence can be mediated by fronts propagating along the genome, whose characteristic signature on genome structure is elucidated, and apparently observed in closely-related {\it Bacillus} strains. Front propagation provides an emergent, generic mechanism for microbial "speciation", and suggests a classification of microorganisms on the basis of their propensity to support propagating fronts.
Cite
@article{arxiv.q-bio/0501033,
title = {Global divergence of microbial genome sequences mediated by propagating fronts},
author = {Kalin Vetsigian and Nigel Goldenfeld},
journal= {arXiv preprint arXiv:q-bio/0501033},
year = {2009}
}