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Intracellular fluctuations, mainly triggered by gene expression, are an inevitable phenomenon observed in living cells. It influences generation of phenotypic diversity in genetically identical cells. Such variation of cellular components…

Molecular Networks · Quantitative Biology 2017-02-08 Alok Kumar Maity , Pinaki Chaudhury , Suman K. Banik

Enzymes show two distinct transport behaviors in the presence of their substrates in solution. First, their diffusivity enhances with increasing substrate concentration. In addition, enzymes perform directional motion toward regions with…

Biological Physics · Physics 2018-11-06 Farzad Mohajerani , Xi Zhao , Ambika Somasundar , Darrell Velegol , Ayusman Sen

The kinematical characteristics of fragments and light particles observed in central highly fragmented nuclear collisions at intermediate energies are compared with the results of a model assuming that the initial momentum distribution of…

Nuclear Experiment · Physics 2007-05-23 A. Van Lauwe , D. Durand et al

The rate-limiting step of some enzymatic reactions is a physical step, i.e. diffusion. The efficiency of such reactions can be improved through an increase in the arrival rate of the substrate molecules, e.g. by a directed passage of…

Biological Physics · Physics 2007-05-23 Mehrdad Ghaemi , Nasrollah Rezaei-Ghaleh , Mohammad-Nabi Sarbolouki

It has been observed experimentally [H.R. Xia, C.Y. Ye, and S.Y. Zhu, Phys. Rev. Lett. {\bf 77}, 1032 (1996)] that quantum interference between two molecular transitions can lead to a suppression or enhancement of spontaneous emission. This…

Quantum Physics · Physics 2009-10-31 Jin Wang , H. M. Wiseman , Z. Ficek

The fusion excitation function is the important quantity in planning experiments for the synthesis of superheavy elements. Its values seem to be determined by the experimental study of the hindrance to complete fusion by the observation of…

Nuclear Theory · Physics 2015-03-19 G Giardina , A K Nasirov , G Mandaglio , F Curciarello , V De Leo , G Fazio , M Manganaro , M Romaniuk , C Saccá

The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium phase separation, they are intrinsically non-equilibrium,…

Biological Physics · Physics 2025-12-10 Damiano Andreghetti , Alfredo Braunstein , Luca Dall'Asta , Andrea Gamba

There are two main quantities involved in the deviation of a stochastic process from a Poisson process: the squared coefficient of variation of the time intervals between adjacent events and the Fano factor of the number of reaction events.…

Statistical Mechanics · Physics 2023-11-02 Seong Jun Park , M. Y. Choi

Heterogenous reactions typically consist of multiple elementary steps and their rate coefficients are of fundamental importance in elucidating the mechanisms and micro-kinetics of these processes. Transition-state theory (TST) for…

Chemical Physics · Physics 2025-03-04 Chen Li , Xiongzhi Zeng , Yongle Li , Zhenyu Li , Hua Guo , Bin Jiang

Most chemical reactions are cascade reactions in which a series of transient intermediates appear and disappear stochastically over an extended period. The mechanisms of such reactions are challenging to study, even in ultrafast pump-probe…

Materials Science · Physics 2022-03-10 Toshiki Shimizu , Dominik Lungerich , Koji Harano , Eiichi Nakamura

Analysis of reactive-diffusion simulations requires a large number of independent model runs. For each high-fidelity simulation, inputs are varied and the predicted mixing behavior is represented by changes in species concentration. It is…

Computational Engineering, Finance, and Science · Computer Science 2019-07-24 V. V. Vesselinov , M. K. Mudunuru , S. Karra , D. O. Malley , B. S. Alexandrov

The classical theory of chemical reactions can be understood in terms of diffusive barrier crossing, where the rate of a reaction is determined by the inverse of the mean first passage time (FPT) to cross a free energy barrier. Whenever a…

Statistical Mechanics · Physics 2019-11-22 David Hartich , Aljaz Godec

Enzymes have been recently proposed to have mechanical activity associated with their chemical activity. In a number of recent studies, it has been reported that enzymes undergo enhanced diffusion in the presence of their corresponding…

Biological Physics · Physics 2021-04-07 Jaime Agudo-Canalejo , Tunrayo Adeleke-Larodo , Pierre Illien , Ramin Golestanian

A method for identifying statistical equilibrium stages in dynamical multifragmentation paths as provided by transport models, already successfully tested for for the reaction ^{129}Xe+^{119}Sn at 32 MeV/u is applied here to a higher energy…

Nuclear Theory · Physics 2008-11-26 A. H. Raduta , M. Colonna , M. Di Toro

Functional data analysis is becoming increasingly popular to study data from real-valued random functions. Nevertheless, there is a lack of multiple testing procedures for such data. These are particularly important in factorial designs to…

Methodology · Statistics 2024-06-04 Merle Munko , Marc Ditzhaus , Markus Pauly , Łukasz Smaga

Dynamic cooperativity in monomeric enzymes is characterized in terms of a non-Michaelis-Menten kinetic behaviour. The latter is believed to be associated with mechanisms that include multiple reaction pathways due to enzymatic…

Chemical Physics · Physics 2016-09-21 Ashutosh Kumar , Sambarta Chatterjee , Mintu Nandi , Arti Dua

Elementary flux modes (EFMs) are pathways through a metabolic reaction network that connect external substrates to products. Using EFMs, a metabolic network can be transformed into its macroscopic counterpart, in which the internal…

Optimization and Control · Mathematics 2014-10-13 Hildur Æsa Oddsdóttir , Erika Hagrot , Véronique Chotteau , Anders Forsgren

A Fano resonance arises from the pathway interference between discrete and continuum states, playing a fundamental role in many branches of physics, chemistry and material science. Here, we introduce the concept of a laser-assisted Fano…

We analyze some variants of the Zeno effect in which the frequent observation of the population of an intermediate state does not prevent the transition of the system from the initial state to a certain final state. This is achieved by…

Quantum Physics · Physics 2024-10-01 Julio Cuadrado , Alfredo Luis

Steric or attractive interactions among reactants or between reactants and inert crowders can substantially influence the total rate of a diffusion-influenced reaction in the liquid phase. However, the role of the product species, that has…

Chemical Physics · Physics 2018-04-19 Rafael Roa , Toni Siegl , Won Kyu Kim , Joachim Dzubiella
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