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Scientific applications produce vast amounts of data, posing grand challenges in the underlying data management and analytic tasks. Progressive compression is a promising way to address this problem, as it allows for on-demand data…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-02 Yanliang Li , Wenbo Li , Qian Gong , Qing Liu , Norbert Podhorszki , Scott Klasky , Xin Liang , Jieyang Chen

Accurately and quickly binuclear cell (BC) detection plays a significant role in predicting the risk of leukemia and other malignant tumors. However, manual microscopy counting is time-consuming and lacks objectivity. Moreover, with the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Baomin Wang , Geng Hu , Dan Chen , Lihua Hu , Cheng Li , Yu An , Guiping Hu , Guang Jia

Single-cell transcriptomics enabled the study of cellular heterogeneity in response to perturbations at the resolution of individual cells. However, scaling high-throughput screens (HTSs) to measure cellular responses for many drugs remains…

Machine Learning · Computer Science 2023-01-03 Leon Hetzel , Simon Böhm , Niki Kilbertus , Stephan Günnemann , Mohammad Lotfollahi , Fabian Theis

RNA molecules exhibit various biological functions intrinsically dependent on their diverse ecosystem of highly flexible structures. This flexibility arises from complex hydrogen-bonding networks defined by canonical and non-canonical base…

Biomolecules · Quantitative Biology 2024-11-08 Tomas F. D. Silva , Giovanni Bussi

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

Accurate enumeration of Salmonella spp. is important for assessing whether this pathogen has survived composting. Recent literature has reported that enumeration of Salmonella spp. using standard microbiological methods has a numbers of…

Quantitative Methods · Quantitative Biology 2014-04-22 N. M. Sunar , D. I. Stewart , E. I. Stentiford , L. A. Flecther

We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of…

Quantitative Methods · Quantitative Biology 2015-06-23 Francesca Volpetti , Jose Garcia-Cordero , Sebastian Maerkl

In chemical processing and bioprocessing, conventional online sensors are limited to measure only basic process variables like pressure and temperature, pH, dissolved O and CO$_2$ and viable cell density (VCD). The concentration of other…

Quantitative Methods · Quantitative Biology 2020-05-07 Semion Rozov

Traffic-responsive signal control is a cost-effective and easy-to-implement network management strategy with high potential in improving performance in congested networks with dynamic characteristics. Max Pressure (MP) distributed…

Systems and Control · Electrical Eng. & Systems 2023-05-03 Dimitrios Tsitsokas , Anastasios Kouvelas , Nikolas Geroliminis

We introduce a new approach to variable selection, called Predictive Correlation Screening, for predictor design. Predictive Correlation Screening (PCS) implements false positive control on the selected variables, is well suited to small…

Machine Learning · Statistics 2013-04-11 Hamed Firouzi , Bala Rajaratnam , Alfred Hero

Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is an assay for DNA-protein-binding or post-translational chromatin/histone modifications. As with all high-throughput technologies, it requires a thorough…

Quantitative Methods · Quantitative Biology 2009-10-20 Benedikt Zacher , Achim Tresch

Low precision arithmetic, in particular half precision floating point arithmetic, is now available in commercial hardware. Using lower precision can offer significant savings in computation and communication costs with proportional savings…

Numerical Analysis · Mathematics 2021-11-16 Eda Oktay , Erin Carson

Kernel methods have been extensively utilized in machine learning for classification and prediction tasks due to their ability to capture complex non-linear data patterns. However, single kernel approaches are inherently limited, as they…

Machine Learning · Computer Science 2026-02-12 Qiyuan Shi , Jian Kang , Yi Li

Peptide microarrays have emerged as a powerful technology in immunoproteomics as they provide a tool to measure the abundance of different antibodies in patient serum samples. The high dimensionality and small sample size of many…

Methodology · Statistics 2021-04-06 Zihao Zheng , Aisha M. Mergaert , Irene M. Ong , Miriam A. Shelef , Michael A. Newton

We developed a novel pathway to highly efficiently synthesize the [60]Fullerene (C$_{60}$)-Cyclodextrin (CD) complex, which is termed as solvent-induced reversible recognition. Three kinds of typical complexes, namely,…

Materials Science · Physics 2022-01-14 Guang-Zhong Yin , De-Yi Wang

We develop and study FPGA implementations of algorithms for charged particle tracking based on graph neural networks. The two complementary FPGA designs are based on OpenCL, a framework for writing programs that execute across heterogeneous…

DNA surface-hybridization biosensors utilize the selective hybridization of target sequences in solution to surface-immobilized probes. In this process, the target is usually assumed to be in excess, so that its concentration does not…

Biomolecules · Quantitative Biology 2019-09-27 Stefanos K. Nomidis , Michal Szymonik , Tom Venken , Enrico Carlon , Jef Hooyberghs

Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides. The resulting mixture of peptides is then subjected…

Applications · Statistics 2010-11-10 Qunhua Li , Michael J. MacCoss , Matthew Stephens

DNA polymerase (DNAP) is a dual-purpose enzyme that plays two opposite roles in two different situations during DNA replication. It plays its normal role as a {\it polymerase} catalyzing the elongation of a new DNA molecule by adding a…

Biological Physics · Physics 2013-08-13 Ajeet K. Sharma , Debashish Chowdhury

Pristine polycrystalline boron-doped diamond electrodes (BDDEs) -- microcrystalline (B-MCDE) and ultrananocrystalline (B-UNCDE) were applied for the electrochemical reduction of several selected purine nucleotides -- Guanosine…

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