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Background: The roles of neuromodulation in a neural network, such as in a cortical microcolumn, are still incompletely understood. Neuromodulation influences neural processing by presynaptic and postsynaptic regulation of synaptic…

Neurons and Cognition · Quantitative Biology 2019-06-25 Gabriele Scheler

Heterogeneity is a ubiquitous property of many biological systems and has profound implications for computation. While it is conceivable to optimize neuronal and synaptic heterogeneity for a specific task, such top-down optimization is…

Machine Learning · Computer Science 2025-12-02 Arash Golmohammadi , Jannik Luboeinski , Christian Tetzlaff

A critical mystery in neuroscience lies in determining how anatomical structure impacts the complex functional dynamics of human thought. How does large-scale brain circuitry constrain states of neuronal activity and transitions between…

Neurons and Cognition · Quantitative Biology 2016-07-08 Shi Gu , Matthew Cieslak , Benjamin Baird , Sarah F. Muldoon , Scott T. Grafton , Fabio Pasqualetti , Danielle S. Bassett

There is evidence that biological synapses have only a fixed number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights as old memories are automatically…

Neurons and Cognition · Quantitative Biology 2008-03-14 Adam B. Barrett , M. C. W. van Rossum

Understanding the theoretical foundations of how memories are encoded and retrieved in neural populations is a central challenge in neuroscience. A popular theoretical scenario for modeling memory function is the attractor neural network…

Neurons and Cognition · Quantitative Biology 2016-02-17 Alireza Alemi , Carlo Baldassi , Nicolas Brunel , Riccardo Zecchina

Self-sustained activity in the brain is observed in the absence of external stimuli and contributes to signal propagation, neural coding, and dynamic stability. It also plays an important role in cognitive processes. In this work, by means…

Precise spatio-temporal patterns of neuronal action potentials underly e.g. sensory representations and control of muscle activities. However, it is not known how the synaptic efficacies in the neuronal networks of the brain adapt such that…

Neurons and Cognition · Quantitative Biology 2015-02-24 Christian Albers , Maren Westkott , Klaus Pawelzik

We have calculated the key characteristics of associative (content-addressable) spatial-temporal memories based on neuromorphic networks with restricted connectivity - "CrossNets". Such networks may be naturally implemented in…

Neural and Evolutionary Computing · Computer Science 2017-07-14 Dmitri Gavrilov , Dmitri Strukov , Konstantin K. Likharev

Many neural systems display cascading behavior characterized by uninterrupted sequences of neuronal firing. This gap precludes an understanding of how variations in network structure manifest in neural dynamics and either support or impinge…

Neurons and Cognition · Quantitative Biology 2019-11-12 Harang Ju , Jason Z. Kim , Danielle S. Bassett

The dynamics of affective decision making is considered for an intelligent network composed of agents with different types of memory: long-term and short-term memory. The consideration is based on probabilistic affective decision theory,…

Artificial Intelligence · Computer Science 2023-09-04 V. I. Yukalov , E. P. Yukalova

Understanding how neural dynamics shape cognitive experiences remains a central challenge in neuroscience and psychiatry. Here, we present a novel framework leveraging state-to-output controllability from dynamical systems theory to model…

Memories in the brain are separated in two categories: short-term and long-term memories. Long-term memories remain for a lifetime, while short-term ones exist from a few milliseconds to a few minutes. Within short-term memory studies,…

Neural and Evolutionary Computing · Computer Science 2014-11-26 Julien Hubert , Takashi Ikegami

The computational capabilities of a neural network are widely assumed to be determined by its static architecture. Here we challenge this view by establishing that a fixed neural structure can operate in fundamentally different…

Neural and Evolutionary Computing · Computer Science 2025-09-24 Xia Chen

It is widely appreciated that well-balanced excitation and inhibition are necessary for proper function in neural networks. However, in principle, such balance could be achieved by many possible configurations of excitatory and inhibitory…

Neurons and Cognition · Quantitative Biology 2018-11-14 Vidit Agrawal , Andrew B. Cowley , Qusay Alfaori , Juan G. Restrepo , Daniel B. Larremore , Woodrow L. Shew

Neuronal connection weights exhibit short-term depression (STD). The present study investigates the impact of STD on the dynamics of a continuous attractor neural network (CANN) and its potential roles in neural information processing. We…

Disordered Systems and Neural Networks · Physics 2011-04-12 C. C. Alan Fung , K. Y. Michael Wong , He Wang , Si Wu

Neural circuits are able to perform computations under very diverse conditions and requirements. The required computations impose clear constraints on their fine-tuning: a rapid and maximally informative response to stimuli in general…

Neurons and Cognition · Quantitative Biology 2019-10-22 Jens Wilting , Jonas Dehning , Joao Pinheiro Neto , Lucas Rudelt , Michael Wibral , Johannes Zierenberg , Viola Priesemann

Working memory often appears to exceed its basic span by organizing items into compact representations called chunks. Chunking can be learned over time for familiar inputs; however, it can also arise spontaneously for novel stimuli. Such…

Neurons and Cognition · Quantitative Biology 2025-09-19 Weishun Zhong , Mikhail Katkov , Misha Tsodyks

It has been proposed that neural noise in the cortex arises from chaotic dynamics in the balanced state: in this model of cortical dynamics, the excitatory and inhibitory inputs to each neuron approximately cancel, and activity is driven by…

Disordered Systems and Neural Networks · Physics 2017-04-28 Nimrod Shaham , Yoram Burak

The $1/f$-like decay observed in the power spectrum of electro-physiological signals, along with scale-free statistics of the so-called neuronal avalanches, constitute evidences of criticality in neuronal systems. Recent in vitro studies…

Neurons and Cognition · Quantitative Biology 2017-08-31 Fabrizio Lombardi , Hans J. Herrmann , Lucilla de Arcangelis

Synfire chains are thought to underlie precisely-timed sequences of spikes observed in various brain regions and across species. How they are formed is not understood. Here we analyze self-organization of synfire chains through the…

Neurons and Cognition · Quantitative Biology 2015-06-16 Aaron Miller , Dezhe Z. Jin