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A linear external perturbation is introduced in the action of the partition function of the random matrix model of RNA [G. Vernizzi, H. Orland and A. Zee, Phys. Rev. Lett. 94, 168103 (2005)]. It is seen that (i). the perturbation…

Biomolecules · Quantitative Biology 2009-11-20 I. Garg , N. Deo

We construct and study an extended random matrix model of RNA (polymer) folding. A perturbation which acts on all the nucleotides in the chain is added to the action of the RNA partition function. The effect of this perturbation on the…

Statistical Mechanics · Physics 2008-04-23 Itty Garg , N. Deo

A non-linear Penner type interaction is introduced and studied in the random matrix model of homo-RNA. The asymptotics in length of the partition function is discussed for small and large $N$ (size of matrix). The interaction doubles the…

Statistical Mechanics · Physics 2011-03-30 Itty Garg , Pradeep Bhadola , N. Deo

The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the…

Subcellular Processes · Quantitative Biology 2023-08-17 Juraj Szavits-Nossan , Ramon Grima

The ensemble of RNA secondary structures of uniform sequences is studied analytically. We calculate the partition function for very long sequences and discuss how the cross-over length, beyond which asymptotic scaling laws apply, depends on…

Biological Physics · Physics 2007-05-23 Tsunglin Liu , Ralf Bundschuh

In cond-mat/9907125 the low-temperature behavior of a model for RNA secondary structure was studied. It is claimed that the model exhibits a breaking of the replica symmetry, since the width of the distribution P(q) of overlaps may converge…

Disordered Systems and Neural Networks · Physics 2009-10-31 Alexander K. Hartmann

Formation of base pairs between the nucleotides of an RNA sequence gives rise to a complex and often highly branched RNA structure. While numerous studies have demonstrated the functional importance of the high degree of RNA branching --…

Biological Physics · Physics 2023-06-21 Domen Vaupotič , Angelo Rosa , Luca Tubiana , Anže Božič

We study the force-induced unfolding of random disordered RNA or single-stranded DNA polymers. The system undergoes a second order phase transition from a collapsed globular phase at low forces to an extensive necklace phase with a…

Soft Condensed Matter · Physics 2009-11-07 M. Mueller , F. Krzakala , M. Mezard

We describe quantitatively a RNA molecule under the influence of an external force exerted at its two ends as in a typical single-molecule experiment. Our calculation incorporates the interactions between nucleotides by using the…

Soft Condensed Matter · Physics 2009-11-07 Ulrich Gerland , Ralf Bundschuh , Terence Hwa

We consider $N\times N$ Gaussian random matrices, whose average density of eigenvalues has the Wigner semi-circle form over $[-\sqrt{2},\sqrt{2}]$. For such matrices, using a Coulomb gas technique, we compute the large $N$ behavior of the…

Statistical Mechanics · Physics 2014-06-30 Ricardo Marino , Satya N. Majumdar , Grégory Schehr , Pierpaolo Vivo

We consider the asymptotic behavior as $n\to\infty$ of the spectra of random matrices of the form \[\frac{1}{\sqrt{n-1}}\sum_{k=1}^{n-1}Z_{nk}\rho_n ((k,k+1)),\] where for each $n$ the random variables $Z_{nk}$ are i.i.d. standard Gaussian…

Probability · Mathematics 2009-06-11 Steven N. Evans

We consider a ${\Lambda}$-coalescent and we study the asymptotic behavior of the total length $L^{(n)}_{ext}$ of the external branches of the associated $n$-coalescent. For Kingman coalescent, i.e. ${\Lambda}={\delta}_0$, the result is well…

Probability · Mathematics 2013-05-24 Jean-Stephane Dhersin , Linglong Yuan

We enumerate the number of RNA contact structures according to their genus, i.e. the topological character of their pseudoknots. By using a recently proposed matrix model formulation for the RNA folding problem, we obtain exact results for…

Biomolecules · Quantitative Biology 2009-11-10 G. Vernizzi , H. Orland , A. Zee

This is a review of the Riemann-Hilbert approach to the large $N$ asymptotics in random matrix models and its applications. We discuss the following topics: random matrix models and orthogonal polynomials, the Riemann-Hilbert approach to…

Mathematical Physics · Physics 2008-06-26 Pavel M. Bleher

We formulate the RNA folding problem as an $N\times N$ matrix field theory. This matrix formalism allows us to give a systematic classification of the terms in the partition function according to their topological character. The theory is…

Statistical Mechanics · Physics 2009-11-07 H. Orland , A. Zee

Using force as a probe to map the folding landscapes of RNA molecules has become a reality thanks to major advances in single molecule pulling experiments. Although the unfolding pathways under tension are complicated to predict studies in…

Biological Physics · Physics 2018-03-14 Changbong Hyeon , D. Thirumalai

The behavior of correlation functions is studied in a class of matrix models characterized by a measure $\exp(-S)$ containing a potential term and an external source term: $S=N\tr(V(M)-MA)$. In the large $N$ limit, the short-distance…

Condensed Matter · Physics 2009-10-30 P. Zinn-Justin

Starting from the form factor expansion in finite volume, we derive the multidimensional generalization of the so-called Natte series for the zero-temperature, time and distance dependent reduced density matrix in the non-linear…

Mathematical Physics · Physics 2011-05-06 K. K. Kozlowski

Let W be an affine PI algebra over a field of characteristic zero graded by a finite group G. We show that there exist $\alpha_{1},\alpha_{2}\in\mathbb{R}, \beta\in\frac{1}{2}\mathbb{Z}$, and $l\in\mathbb{N}$ such that…

Rings and Algebras · Mathematics 2015-04-03 Yuval Shpigelman

RNA polymerase (RNAP) is a mobile molecular workshop that polymerizes a RNA molecule by adding monomeric subunits one by one, while moving step by step on the DNA template itself. Here we develop a theoretical model by incorporating the…

Biological Physics · Physics 2009-06-04 Tripti Tripathi , Prasanjit Prakash , Debashish Chowdhury
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