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We investigate saddlepoint approximations applied to the score test statistic in genome-wide association studies with binary phenotypes. The inaccuracy in the normal approximation of the score test statistic increases with increasing sample…

For a high-dimensional linear model with a finite number of covariates measured with error, we study statistical inference on the parameters associated with the error-prone covariates, and propose a new corrected decorrelated score test and…

Methodology · Statistics 2020-01-29 Mengyan Li , Runze Li , Yanyuan Ma

This paper provides a general framework to study the effect of sampling properties of training data on the generalization error of the learned machine learning (ML) models. Specifically, we propose a new spectral analysis of the…

Machine Learning · Computer Science 2019-06-11 Bhavya Kailkhura , Jayaraman J. Thiagarajan , Qunwei Li , Peer-Timo Bremer

In the context of the usual calibration model, we consider the case in which the independent variable is unobservable, but a pre-fixed value on its surrogate is available. Thus, considering controlled variables and assuming that the…

Applications · Statistics 2008-02-06 Betsabé G. Blas Achic , Mônica C. Sandoval , Olga Satomi Yoshida

This paper studies empirical risk minimization (ERM) problems for large-scale datasets and incorporates the idea of adaptive sample size methods to improve the guaranteed convergence bounds for first-order stochastic and deterministic…

Machine Learning · Computer Science 2017-09-05 Aryan Mokhtari , Alejandro Ribeiro

Classical learning of the expectation values of observables for quantum states is a natural variant of learning quantum states or channels. While learning-theoretic frameworks establish the sample complexity and the number of measurement…

Quantum Physics · Physics 2024-08-12 Beng Yee Gan , Po-Wei Huang , Elies Gil-Fuster , Patrick Rebentrost

In a statistical analysis in Particle Physics, nuisance parameters can be introduced to take into account various types of systematic uncertainties. The best estimate of such a parameter is often modeled as a Gaussian distributed variable…

Data Analysis, Statistics and Probability · Physics 2019-02-25 Glen Cowan

We go through the many considerations involved in fitting a model to data, using as an example the fit of a straight line to a set of points in a two-dimensional plane. Standard weighted least-squares fitting is only appropriate when there…

Instrumentation and Methods for Astrophysics · Physics 2010-08-30 David W. Hogg , Jo Bovy , Dustin Lang

In QM/MM indirect free energy simulation, QM/MM corrections can be obtained from integration of partial derivatives of alchemical Hamiltonians or from perturbation-based estimators including free energy perturbation (FEP) and acceptance…

Chemical Physics · Physics 2018-10-05 Xiaohui Wang , Zhaoxi Sun

Simulation offers a simple and flexible way to estimate the power of a clinical trial when analytic formulae are not available. The computational burden of using simulation has, however, restricted its application to only the simplest of…

We comment on the reweighting method for the study of finite density lattice QCD. We discuss the applicable parameter range of the reweighting method for models which have more than one simulation parameter. The applicability range is…

High Energy Physics - Lattice · Physics 2009-11-10 Shinji Ejiri

Software project management makes extensive use of predictive modeling to estimate product size, defect proneness and development effort. Although uncertainty is acknowledged in these tasks, fuzzy inference systems, designed to cope well…

Software Engineering · Computer Science 2021-02-08 Stephen G. MacDonell

Survival models incorporating random effects to account for unmeasured heterogeneity are being increasingly used in biostatistical and applied research. Specifically, unmeasured covariates whose lack of inclusion in the model would lead to…

Methodology · Statistics 2020-05-06 Alessandro Gasparini , Mark S. Clements , Keith R. Abrams , Michael J. Crowther

We theoretically explore the relationship between sample-efficiency and adaptivity in reinforcement learning. An algorithm is sample-efficient if it uses a number of queries $n$ to the environment that is polynomial in the dimension $d$ of…

Machine Learning · Computer Science 2024-05-29 Emmeran Johnson , Ciara Pike-Burke , Patrick Rebeschini

Machine learning models are often used to inform real world risk assessment tasks: predicting consumer default risk, predicting whether a person suffers from a serious illness, or predicting a person's risk to appear in court. Given…

Machine Learning · Computer Science 2023-06-27 Jamelle Watson-Daniels , David C. Parkes , Berk Ustun

Prediction intervals in supervised Machine Learning bound the region where the true outputs of new samples may fall. They are necessary in the task of separating reliable predictions of a trained model from near random guesses, minimizing…

Machine Learning · Computer Science 2019-12-20 Anton Akusok , Yoan Miche , Kaj-Mikael Björk , Amaury Lendasse

Existing approaches to sample size calculations for developing clinical prediction models have focused on ensuring that the expected value of a chosen performance measure meets a pre-specified target. For example, to limit…

Methodology · Statistics 2025-09-18 Menelaos Pavlou , Rumana Z. Omar , Gareth Ambler

Training classical neural networks generally requires a large number of training samples. Using entangled training samples, Quantum Neural Networks (QNNs) have the potential to significantly reduce the amount of training samples required in…

Quantum Physics · Physics 2023-12-12 Alexander Mandl , Johanna Barzen , Frank Leymann , Daniel Vietz

Resampling methods are especially well-suited to inference with estimators that provide only "black-box'' access. Jackknife is a form of resampling, widely used for bias correction and variance estimation, that is well-understood under…

Statistics Theory · Mathematics 2024-11-06 Licong Lin , Fangzhou Su , Wenlong Mou , Peng Ding , Martin Wainwright

Equivariant models leverage prior knowledge on symmetries to improve predictive performance, but misspecified architectural constraints can harm it instead. While work has explored learning or relaxing constraints, selecting among…

Machine Learning · Computer Science 2025-07-16 Putri A. van der Linden , Alexander Timans , Dharmesh Tailor , Erik J. Bekkers