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Ion accelerators have been used by material scientists for decades to investigate radiation damage formation in nuclear materials and thus to emulate neutron-induced changes. The versatility of conditions in terms of particle energy, dose…

Instrumentation and Detectors · Physics 2019-08-05 A. Gentils , C. Cabet

Relative biological effectiveness (RBE) is a key quantity for the description of radiobiological effects induced by charged-particle irradiation in the context of ion-beam cancer therapy. Since RBE is a complex function that depends on…

Medical Physics · Physics 2021-07-09 Alexey Verkhovtsev , Eugene Surdutovich , Andrey V. Solov'yov

Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most…

Carbon ion beam radiotherapy enables a very localised dose deposition. However, already small changes in the patient geometry or positioning errors can significantly distort the dose distribution. A live monitoring system of the beam…

Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we…

Accelerator Physics · Physics 2015-06-17 Hywel Owen , David Holder , Jose Alonso , Ranald MacKay

Spincoated polystyrene films of different thickness from 78 nm to 1.3 {\mu}m on silicon wafers were treated by nitrogen ions with an energy of 20 keV. Ellipsometric measurements and FTIR spectra showed modification of the surface layer…

Chemical Physics · Physics 2025-03-27 Alexey Kondyurin

After the discovery of laser therapy it was realized it has useful application of wound healing and reduce pain, but due to the poor understanding of the mechanism and dose response this technique remained to be controversial for…

Medical Physics · Physics 2016-06-16 Muhammad Zeeshan Khalid

With the continued evolution of modern radiation therapy towards high precision delivery of high therapeutic doses to the tumour while optimally sparing surrounding healthy tissue, imaging becomes a crucial component to identify the…

Medical Physics · Physics 2018-04-24 Katia Parodi

Ion beam has been used in cancer treatment, and has a unique preferable feature to deposit its main energy inside a human body so that cancer cell could be killed by the ion beam. However, conventional ion accelerator tends to be huge in…

Ion beam analysis techniques are among the most powerful tools for advanced material characterization. Despite their growing relevance in a widening number of fields, most ion beam analysis facilities still rely on the oldest accelerator…

Plasma Physics · Physics 2019-03-06 Matteo Passoni , Luca Fedeli , Francesco Mirani

Nanomaterials often undergo unusual mechanical deformations compared to their bulk counterparts when irradiated with ion-beams. This study visualizes and investigates some of the unusual interactions that can occur in nanomaterials during…

Materials Science · Physics 2018-02-15 Morteza Aramesh

Ion beams are used routinely for processing of semiconductors, particularly sputtering, ion implantation and direct-write fabrication of nanostructures. However, the utility of ion beam techniques is limited by crystal damage and surface…

Materials Science · Physics 2022-09-21 John A. Scott , James Bishop , Milos Toth

Numerical simulations are performed on a stochastic model based on Monte Carlo damage simulation process and Markov Chain Monte Carlo techniques to investigate the formation and evaluation of isolated and multiple DNA damage and cellular…

Quantitative Methods · Quantitative Biology 2019-11-20 M. Loan , B. Freeman , A. Bhat , M. Tantary , M. Brown , K. Virk

Beams of radioactive heavy ions allow researchers to study rare and unstable atomic nuclei, shedding light into the internal structure of exotic nuclei and on how chemical elements are formed in stars. However, the extraction and transport…

Accelerator Physics · Physics 2025-06-25 Sergio Lopez-Caceres , Daniel Santiago-Gonzalez

The passage of energetic ions through tissue initiates a series of physico-chemical events, which lead to biodamage. The study of this scenario using a multiscale approach brought about the theoretical prediction of shock waves initiated by…

Biological Physics · Physics 2021-07-28 Pablo de Vera , Eugene Surdutovich , Nigel J. Mason , Fred J. Currell , Andrey V. Solov'yov

Purpose: A novel approach using nano technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies…

Medical Physics · Physics 2012-06-25 F. Van den Heuvel , J. P. Locquet , S. Nuyts

In this second part of a series we attempt to construct an empirical model that can mimick all experimental observations made regarding the role of an alternative interleaved scan pattern in STEM imaging on the beam damage in a specific…

Materials Science · Physics 2021-05-03 D. Jannis , A. Velazco , A. Béché , J. Verbeeck

Using multiple ion beam analysis measurements, or techniques, combined with self-consistent data processing, generally allows extracting more (or more accurate) information from the measurements than processing separately data from single…

Data Analysis, Statistics and Probability · Physics 2022-11-23 Tiago F. Silva , Cleber L. Rodrigues , Manfredo H. Tabacniks , Udo von Toussaint , Matej Mayer

Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical…

Medical Physics · Physics 2014-10-07 Leszek Grzanka

It has been reported that damage of genome in a living cell by ionizing radiation is about one-third direct and two-thirds indirect. The former which has been introduced in our last paper, concerns direct energy deposition and ionizing…

Biological Physics · Physics 2010-04-27 Wei Wang , Zengliang Yu , Wenhui Su