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Heterogeneous mechanical dyskinesis during acute myocardial ischaemia is thought to contribute to arrhythmogenic alterations to cardiac electrophysiology. Various forms of mechano-electric coupling (MEC) mechanisms have been suggested to…
Brain tumor resection is a highly complex procedure with profound implications for survival and quality of life. Predicting patient outcomes is crucial to guide clinicians in balancing oncological control with preservation of neurological…
Synchronization of brain activity fluctuations is believed to represent communication between spatially distant neural processes. These inter-areal functional interactions develop in the background of a complex network of axonal connections…
Burn-induced insulin resistance is associated with increased morbidity and mortality; however, the impact of burn injury on tissue-specific insulin sensitivity and its molecular mechanisms with consideration of insulin state remains unknown…
We analyze the response of the Hodgkin-Huxley neuron to a large number of uncorrelated stochastic inhibitory and excitatory post-synaptic spike trains. In order to clarify the various mechanisms responsible for noise-induced spike…
Electrical and chemical synapses shape the dynamics of neural networks and their functional roles in information processing have been a longstanding question in neurobiology. In this paper, we investigate the role of synapses on the…
Predicting the final ischaemic stroke lesion provides crucial information regarding the volume of salvageable hypoperfused tissue, which helps physicians in the difficult decision-making process of treatment planning and intervention.…
The branching process is the minimal model for propagation dynamics, avalanches and criticality, broadly used in neuroscience. A simple extension of it, adding inhibitory nodes, induces a much-richer phenomenology, including, an…
This article focuses on current and emerging therapeutics for CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). CADASIL is an inherited vascular disease that impairs blood flow in the…
We review current thinking about, and draw connections between, brain energetics and metabolism, mitochondria and traumatic brain injury. In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework…
Working memory (WM) was one of the first cognitive processes studied with functional magnetic resonance imaging. With now over 20 years of studies on WM, each study with tiny sample sizes, there is a need for meta-analysis to identify the…
Many coordination phenomena in Nature are grounded on a synchronisation regime. In the case of brain dynamics, such self-organised process allows the neurons of particular brain regions to behave as a whole and thus directly controlling the…
The study involved 56 patients with advanced and late stages of Parkinsons disease, which could be considered as potentially requiring neurosurgical treatment-electrical stimulation of deep brain structures. An algorithm has been developed…
Combination chemotherapy treatment regimens created for patients diagnosed with childhood acute lymphoblastic leukemia have had great success in improving cure rates. Unfortunately, patients prescribed these types of treatment regimens have…
Malfunctioning neurons in the brain sometimes operate synchronously, reportedly causing many neurological diseases, e.g. Parkinson's. Suppression and control of this collective synchronous activity are therefore of great importance for…
Despite intensive research, the mechanisms underlying how neurons encode external inputs remain poorly understood. Recent work has focused on the response of a single neuron to a weak, subthreshold periodic signal. By simulating the…
In this paper we first recall the definition of geometical model of the visual cortex, focusing in particular on the geometrical properties of horizontal cortical connectivity. Then we recognize that histograms of edges - co-occurrences are…
Cerebrovascular disease is a leading cause of death globally. Prevention and early intervention are known to be the most effective forms of its management. Non-invasive imaging methods hold great promises for early stratification, but at…
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the…
In this work we propose a new biophysical computational model of brain regions relevant to Parkinson's Disease based on local field potential data collected from the brain of marmoset monkeys. Parkinson's disease is a neurodegenerative…