Related papers: Ricci Flow and Entropy Model for Avascular Tumor G…
In this paper, we investigate the tumor instability by employing both analytical and numerical techniques to validate previous results and extend the analytical findings presented in a prior study by Feng et al 2023. Building upon the…
Imposing non-integrable constraints on Ricci flows of (pseudo) Riemannian metrics we model mutual transforms to, and from, non-Riemannian spaces. Such evolutions of geometries and physical theories can be modelled for nonholonomic manifolds…
Employing a novel two-dimensional computational model we have simulated the feedback between angiogenesis and tumor growth dynamics. Analyzing vessel formation and elongation towards the concentration gradient of the tumor-derived…
Cancer cells are widely known to be protected from apoptosis, which is a major hurdle to successful anti-cancer therapy. Over-expression of several anti-apoptotic proteins, or mutations in pro-apoptotic factors, has been recognized to…
A mathematical model for the quantitative analysis of cancer immune interaction, considering the role of antibodies has been proposed in this paper. The model is based on the clinical evidence, which states that antibodies can directly kill…
Based on the framework of Koch-Lamm and tensor heat kernel estimates, we obtain a uniform proof of the short-time existence, uniqueness, and continuous dependence for Ricci flows starting from a complete Riemannian metric with bounded…
We present a new mathematical model of colorectal cancer growth and its response to monoclonal-antibody (mAb) therapy. Although promising, most mAb drugs are still in trial phases, and the possible variations in the dosing schedules of…
We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy. The bottom-up model deduction eventually leads to a system of reaction-diffusion-taxis equations…
Using a recently developed piecewise flat method, numerical evolutions of the Ricci flow are computed for a number of manifolds, using a number of different mesh types, and shown to converge to the expected smooth behaviour as the mesh…
The competition between cancer cells and immune system cells in inhomogeneous conditions is described at cell scale within the framework of the thermostatted kinetic theory. Cell learning is reproduced by increased cell activity during…
We study the short-time existence and regularity of solutions to a boundary value problem for the Ricci-DeTurck equation on a manifold with boundary. Using this, we prove the short-time existence and uniqueness of the Ricci flow prescribing…
It is widely recognized that reciprocal interactions between cells and their microenvironment, via mechanical forces and biochemical signaling pathways, regulate cell behaviors during normal development, homeostasis and disease progression…
Tumour invasion is an essential stage of cancer progression. Its main drivers are diffusion and taxis, a directed movement along the gradient of a stimulus. Here we review models with flux limited diffusion and/or taxis which have…
A lattice based method will be presented for numerical investigations of Ricci flow. The method will be applied to the particular case of 2-dimensional axially symmetric initial data on manifolds with S^2 topology. Results will be presented…
In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We…
The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…
We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the…
In recent years, there has been a spike in the interest in multi-phase tissue growth models. Depending on the type of tissue, the velocity is linked to the pressure through Stoke's law, Brinkman's law or Darcy's law. While each of these…
We develop a new four-phase tumor growth model with angiogenesis, derived from a diffuse-interface mixture model composed by a viable, a necrotic, a liquid and an angiogenetic component, coupled with two massless chemicals representing a…
We give a global picture of the Ricci flow on the space of three-dimensional, unimodular, nonabelian metric Lie algebras considered up to isometry and scaling. The Ricci flow is viewed as a two-dimensional dynamical system for the evolution…