Related papers: Ricci Flow and Entropy Model for Avascular Tumor G…
We consider the Ricci flow for simply connected nilmanifolds, which translates to a Ricci flow on the space of nilpotent metric Lie algebras. We consider the evolution of the inner product and the evolution of structure constants, as well…
We present numerical visualizations of Ricci Flow of surfaces and 3-dimensional manifolds of revolution. Ricci_rot is an educational tool which visualizes surfaces of revolution moving under Ricci flow. That these surfaces tend to remain…
We consider a class of tumor growth models under the combined effects of density-dependent pressure and cell multiplication, with a free boundary model as its singular limit when the pressure-density relationship becomes highly nonlinear.…
We study a simplified stochastic model for the vascularization of a growing tumor, incorporating the formation of new blood vessels at the tumor periphery as well as their regression in the tumor center. The resulting morphology of the…
The geometry of a ball within a Riemannian manifold is coarsely controlled if it has a lower bound on its Ricci curvature and a positive lower bound on its volume. We prove that such coarse local geometric control must persist for a…
An optimal control problem for a model of tumor growth is studied. In a given subdomain, it is required to minimize the density of tumor cells, while the drug concentration in tissue is limited by given minimal and maximal values. Based on…
Modeling inviscid compressible flows with shocks and vortex dominated dynamics remains challenging for particle grid methods due to moving discontinuities, cell crossing noise, and quadrature degradation under strong deformation. Building…
We characterize the conjugate linearized Ricci flow and the associated backward heat kernel on closed three--manifolds of bounded geometry. We discuss their properties, and introduce the notion of Ricci flow conjugated constraint sets which…
We study an optimal control problem for a stochastic model of tumour growth with drug application. This model consists of three stochastic hyperbolic equations describing the evolution of tumour cells. It also includes two stochastic…
Colorectal cancer (CRC) is highly heterogeneous, with five-year survival rates dropping from $\sim$90% in localized disease to $\sim$15% with distant metastases. Disease progression is shaped not only by tumor-intrinsic alterations but also…
The Ricci flow is an evolution system on metrics. For a given metric as initial data, its local existence and uniqueness on compact manifolds was first established by Hamilton \cite{Ha1}. Later on, De Turck \cite{De} gave a simplified…
We derive one unified formula for Ricci curvature tensor on arbitrary warped product manifold by introducing a new notation for the lift vector and the Levi-Civita connection.This formula is helpful to further consider Ricci flow (RF) and…
In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent…
Glioblastoma are known to infiltrate the brain parenchyma instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain…
The nervous system is today recognized to play an important role in the development of cancer. Indeed, neurons extend long processes (axons) that grow and infiltrate tumors in order to regulate the progression of the disease in a positive…
Diffuse gliomas are highly infiltrative tumors whose early diagnosis and follow-up usually rely on magnetic resonance imaging (MRI). However, the limited sensitivity of this technique makes it impossible to directly assess the extent of the…
We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…
A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor reoccurs. Genome sequencing and…
In this paper, we study a phase-space analysis of a mathematical model of tumor growth with an immune response. Mathematical analysis of the model equations with multipoint initial condition, regarding to dissipativity, boundedness of…
Herewith we discuss a network model of the ferroptosis avascular and vascular tumor growth based on our previous proposed framework. Chiefly, ferroptosis should be viewed as a first order phase transition characterized by a supercritical…