Related papers: Ricci Flow and Entropy Model for Avascular Tumor G…
We investigate a recently proposed cross-diffusion system modelling the growth of gliobastoma taking into account size exclusion both in the migration and proliferation process. In addition to degenerate nonlinear cross-diffusion the model…
In this paper, we studied phase-space analysis of a certain mathematical model of tumor growth with an immune responses and chemotherapy therapy. Mathematical modelling of this process is viewed as a potentially powerful tool in the…
A nutrient-limited model for avascular cancer growth including cell proliferation, motility and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are…
Phenotype variations define heterogeneity of biological and molecular systems, which play a crucial role in several mechanisms. Heterogeneity has been demonstrated in tumor cells. Here, samples from blood of patients affected from colon…
Waterfall plots are a key tool in early phase oncology clinical studies for visualizing individual patients' tumor size changes and provide efficacy assessment. However, comparing waterfall plots from ongoing studies with limited follow-up…
We derive a Cahn-Hilliard-Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a…
We discuss a natural form of Ricci--flow conjugation between two distinct general relativistic data sets given on a compact $n\geq 3$-dimensional manifold $\Sigma$. We establish the existence of the relevant entropy functionals for the…
The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel…
We develop and analyze a mathematical model of oncolytic virotherapy in the treatment of melanoma. We begin with a special, local case of the model, in which we consider the dynamics of the tumour cells in the presence of an oncolytic virus…
We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…
In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework…
Glioma, an aggressive brain malignancy characterized by rapid progression and its poor prognosis, poses significant challenges for accurate evolution prediction. These challenges are exacerbated by sparse, irregularly acquired longitudinal…
In 2004, Manning showed that the topological entropy of the geodesic flow for a surface of negative curvature decreases as the metric evolves under the normalised Ricci flow. It is an interesting open problem, also due to Manning, to…
The Ricci flow is a heat equation for metrics, which has recently been used to study the topology of closed three manifolds. In this paper we apply Ricci flow techniques to general relativity. We view a three dimensional asymptotically flat…
We introduce a new entropy functional for nonnegative solutions of the heat equation on a manifold with time-dependent Riemannian metric. Under certain integral assumptions, we show that this entropy is non-decreasing, and moreover convex…
Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of…
In this manuscript, we study a nonlinear model of tumor growth, described by a coupled hyperbolic-elliptic system of partial differential equations. In this model, the compressible flow of tumor cells is modeled by a transport equation for…
We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…
Metastatic tumors often invade healthy neighboring tissues by forming multicellular finger-like protrusions emerging from the cancer mass. To understand the mechanical context behind this phenomenon, we here develop a minimalist fluid model…
We consider a one-dimensional version of a model obtained in [C. Engwer, A. Hunt, and C. Surulescu: Effective equations for anisotropic glioma spread with proliferation: a multiscale approach and comparisons with previous settings, IMA J.…