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We investigate the dynamics of polymer translocation through nanopores under external driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average translocation time $\tau$ versus the length of the polymer, $\tau\sim…

Soft Condensed Matter · Physics 2010-01-04 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Ralf Metzler

We investigate several scaling properties of a translocating homopolymer through a thin pore driven by an external field present inside the pore only using Langevin Dynamics (LD) simulation in three dimension (3D). Specifically motivated by…

We suggest a theoretical description of the force-induced translocation dynamics of a polymer chain through a nanopore. Our consideration is based on the tensile (Pincus) blob picture of a pulled chain and the notion of propagating front of…

Soft Condensed Matter · Physics 2012-04-17 J. L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

We study the translocation of a flexible polymer through extended patterned pores using molecular dynamics (MD) simulations. We consider cylindrical and conical pore geometries that can be controlled by the angle of the pore apex $\alpha$.…

Soft Condensed Matter · Physics 2026-02-11 Andri Sharma , Abhishek Chaudhuri , Rajeev Kapri

We consider the dynamics of polymer translocation out of confined environments. Analytic scaling arguments lead to the prediction that the translocation time scales like $\tau\sim N^{\beta+\nu_{2D}}R^{1+(1-\nu_{2D})/\nu}$ for translocation…

Soft Condensed Matter · Physics 2009-08-11 Kaifu Luo , Ralf Metzler , Tapio Ala-Nissila , See-Chen Ying

We investigate the dynamics of polymer translocation through a nanopore under an externally applied field using the 2D fluctuating bond model with single-segment Monte Carlo moves. We concentrate on the influence of the field strength $E$,…

Soft Condensed Matter · Physics 2011-08-26 Kaifu Luo , Ilkka Huopaniemi , Tapio Ala-Nissila , See-Chen Ying

We study the translocation dynamics of a polymer chain threaded through a nanopore by an external force. By means of diverse methods (scaling arguments, fractional calculus and Monte Carlo simulation) we show that the relevant dynamic…

Statistical Mechanics · Physics 2007-07-29 J. L. A. Dubbeldam , A. Milchev , V. G. Rostiashvili , T. A. Vilgis

The translocation dynamics of a polymer chain through a nanopore in the absence of an external driving force is analyzed by means of scaling arguments, fractional calculus, and computer simulations. The problem at hand is mapped on a one…

Soft Condensed Matter · Physics 2007-07-29 J. L. A. Dubbeldam , A. Milchev , V. G. Rostiashvili , T. A. Vilgis

DNA translocation through nanopores is one of the most promising strategies for the next-generation sequencing technologies. Most part of experimental and numerical works has focused on polymer translocation biased by electrophoresis, where…

Soft Condensed Matter · Physics 2018-02-07 Timothée Menais

We discuss multiscale simulations of long biopolymer translocation through wide nanopores that can accommodate multiple polymer strands. The simulations provide clear evidence of folding quantization, namely, the translocation proceeds…

Biological Physics · Physics 2009-11-13 Simone Melchionna , Massimo Bernaschi , Maria Fyta , Efthimios Kaxiras , Sauro Succi

We investigate the process of biopolymer translocation through a narrow pore using a multiscale approach which explicitly accounts for the hydrodynamic interactions of the molecule with the surrounding solvent. The simulations confirm that…

Biological Physics · Physics 2009-01-16 Maria Fyta , Simone Melchionna , Sauro Succi , Efthimios Kaxiras

Polymer translocation through a nanopore in a membrane investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in…

Statistical Mechanics · Physics 2009-11-07 Elena Slonkina , Anatoly B. Kolomeisky

In forced polymer translocation, the average translocation time, $\tau$, scales with respect to pore force, $f$, and polymer length, $N$, as $\tau \sim f^{-1} N^{\beta}$. We demonstrate that an artifact in Metropolis Monte Carlo method…

Biological Physics · Physics 2009-11-13 V. V. Lehtola , R. P. Linna , K. Kaski

One of the most fundamental quantities associated with polymer translocation through a nanopore is the translocation time $\tau$ and its dependence on the chain length $N$. Our simulation results based on both the bond fluctuation Monte…

Soft Condensed Matter · Physics 2008-11-08 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Pawel Pomorski , Mikko Karttunen

Here using LAMMPS molecular dynamics (MD) software, we simulate polymer translocation in 2 dimensions. We do the simulations for weak and moderate forces and for different pore diameters. Our results show that in both non-equilibrium and…

Computational Physics · Physics 2018-04-26 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

Theoretical derivation and numerical confirmation are provided for the scaling of pore-blockade times as $N^{2+\nu}$ for unbiased translocation in two and three dimensions, with $N$ as the polymer length and $\nu$ as the Flory exponent of…

Soft Condensed Matter · Physics 2010-02-12 Debabrata Panja , Gerard T. Barkema

We investigate the dynamics of polymer translocation through a nanopore using two-dimensional Langevin dynamics simulations. In the absence of external driving force, we consider a polymer which is initially placed in the middle of the pore…

Soft Condensed Matter · Physics 2007-05-23 Ilkka Huopaniemi , Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying

Translocation through a nanopore is a new experimental technique to probe physical properties of biomolecules. A bulk of theoretical and computational work exists on the dependence of the time to translocate a single unstructured molecule…

Biomolecules · Quantitative Biology 2009-05-04 Malcolm McCauley , Robert Forties , Ulrich Gerland , Ralf Bundschuh

We present a theoretical description of the dynamics of a semi-flexible polymer being pulled through a nanopore by an external force acting at the pore. Our theory is based on the tensile blob picture of Pincus in which the front of the…

Statistical Mechanics · Physics 2015-09-16 Pui-Man Lam , Yi Zhen

We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory (IFTP), and extensive molecular dynamics (MD) simulations. We show that in contrast to…

Soft Condensed Matter · Physics 2016-12-28 Jalal Sarabadani , Timo Ikonen , Harri Mökkönen , Tapio Ala-Nissila , Spencer Carson , Meni Wanunu
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