Related papers: Microfluidic Device for Continuous Magnetophoretic…
A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…
Within microcentrifuge devices, a microfluidic vortex separates larger particles from a heterogeneous suspension using inertial migration, a phenomenon that causes particles to migrate across streamlines. The ability to selectively capture…
Minimally invasive interventions performed inside brain vessels with the synergistic use of microcatheters pushed over guidewires have revolutionized the way aneurysms, stroke, arteriovenous malformations, brain tumors and other…
Micromagnetic beads are widely used in biomedical applications for cell separation, drug delivery, and hypothermia cancer treatment. Here we propose to use self-organized magnetic bead structures which accumulate on fixed magnetic seeding…
Mucociliary clearance in mammals serves as the primary defense mechanism for removing particulate matter deposited in the pulmonary airways. Dysfunctions in this process are linked to serious respiratory diseases and can hinder effective…
A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…
We present a microfluidic platform for the continuous separation of suspended particles based on their size and settling velocity. The separation method takes advantage of the flow field in the vicinity and inside a parallel array of…
We propose a modified suspension balance model (SBM) for the flow of red blood cells (RBCs) and other deformable particle suspensions in confined geometries. Specifically, the method includes the hydrodynamic lift force generated by…
We present a microfluidic platform for two-dimensional manipulation of water droplets immersed in bulk oil-based ferrofluid. Although non-magnetic, the droplets are exclusively controlled by magnetic fields, without any pressure-driven…
We combine confocal imaging, microfluidics and image analysis to record 3D-images of cells in flow. This enables us to recover the full 3D representation of several hundred living cells per minute. Whereas 3D confocal imaging has thus far…
Ferrohydrodynamic microfluidics relies on magnetic field gradients to manipulate diamagnetic particles in ferrofluid-filled microenvironments. It has emerged as a promising tool for label-free manipulation of bioparticles, including their…
Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper…
The analysis and counting of blood cells in a microscope image can provide useful information concerning to the health of a person. In particular, morphological analysis of red blood cells deformations can effectively detect important…
We demonstrate the design, fabrication and use of a dual electrode PMUT (Piezoelectric Micromachined Ultrasound Transducer) integrated with a microfluidic channel as a fluid density sensor in both static and dynamic density-change…
In the field of biomedicine magnetic beads are used for drug delivery and to treat hyperthermia. Here we propose to use self-organized bead structures to isolate circulating tumor cells using lab-on-chip technologies. Typically blood flows…
This chapter presents an overview of microfluidic devices reported in the literature, used to develop methodologies for nucleation of biomolecules, with crystal size control, and for collecting thermodynamic and kinetic data. Part I is…
Microdialysis is a well-established method for in vivo neurochemical measurements of small molecules, with implanted concentric-design probes offering minimized tissue damage and good temporal and spatial resolution. However, the large…
Spatial separation of suspended particles based on contrast in their physical or chemical properties forms the basis of various biological assays performed on lab-on-achip devices. To electronically acquire this information, we have…
Dielectrophoresis is an electric field-based technique for moving neutral particles through a fluid. When used for particle separation, dielectrophoresis has many advantages compared to other methods, providing label-free operation with…
We reveal an unreported physical mechanism that enables the pre-concentration, sorting and characterization of charged polystyrene nanobeads and liposomes dispersed in a continuous flow within a straight micron-sized channel. Initially, a…