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We present a novel coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant…

Biological Physics · Physics 2009-11-06 G. Getz , E. Levine , E. Domany

This paper introduces a Projected Principal Component Analysis (Projected-PCA), which employs principal component analysis to the projected (smoothed) data matrix onto a given linear space spanned by covariates. When it applies to…

Methodology · Statistics 2016-01-18 Jianqing Fan , Yuan Liao , Weichen Wang

Accurate and efficient fluid flow models are essential for applications relating to many physical phenomena including geophysical, aerodynamic, and biological systems. While these flows may exhibit rich and multiscale dynamics, in many…

Fluid Dynamics · Physics 2024-08-27 Benjamin D. Shaffer , Jeremy R. Vorenberg , M. Ani Hsieh

In this work we investigate the Principal Component Analysis (PCA) sensitivity to the velocity power spectrum in high opacity regimes of the interstellar medium (ISM). For our analysis we use synthetic Position-Position-Velocity (PPV) cubes…

Motivation: Flow Injection Analysis coupled to High-Resolution Mass Spectrometry (FIA-HRMS) is a promising approach for high-throughput metabolomics. FIA-HRMS data, however, cannot be preprocessed with current software tools which rely on…

Quantitative Methods · Quantitative Biology 2017-08-15 Alexis Delabrière , Ulli Hohenester , Benoit Colsch , Christophe Junot , François Fenaille , Etienne Thévenot

This article focuses on covariance estimation for multi-view data. Popular approaches rely on factor-analytic decompositions that have shared and view-specific latent factors. Posterior computation is conducted via expensive and brittle…

Methodology · Statistics 2026-04-20 Lorenzo Mauri , David B. Dunson

We study two aspects of information semantics: (i) the collection of all relationships, (ii) tracking and spotting anomaly and change. The first is implemented by endowing all relevant information spaces with a Euclidean metric in a common…

Artificial Intelligence · Computer Science 2011-01-11 Fionn Murtagh

Recently, there has been a resurgence of interest in rigorous algorithms for the inference of cancer progression from genomic data. The motivations are manifold: (i) growing NGS and single cell data from cancer patients, (ii) need for novel…

Machine Learning · Computer Science 2016-02-25 Daniele Ramazzotti

Tumor shape is a key factor that affects tumor growth and metastasis. This paper proposes a topological feature computed by persistent homology to characterize tumor progression from digital pathology and radiology images and examines its…

Computer Vision and Pattern Recognition · Computer Science 2023-03-01 Chul Moon , Qiwei Li , Guanghua Xiao

Particle Image Velocimetry (PIV) is a method to visualize the flows and quantitatively map the flows. It is used to obtain the instantaneous velocity, vorticity, divergence, shear in fluids, etc. Laser Doppler velocimetry and hot wire…

Image and Video Processing · Electrical Eng. & Systems 2020-04-23 S. Anand , R. Poovitha , K. Nikhila

Modal analysis techniques are used to identify patterns and develop reduced-order models in a variety of fluid applications. However, experimentally acquired flow fields may be corrupted with incorrect and missing entries, which may degrade…

In this paper, we implement Principal Component Analysis (PCA) to study the single particle distributions generated from thousands of {\tt VISH2+1} hydrodynamic simulations with an aim to explore if a machine could directly discover flow…

Nuclear Theory · Physics 2020-01-08 Ziming Liu , Wenbin Zhao , Huichao Song

Machine learning (ML) methods have proved to be a very successful tool in physical sciences, especially when applied to experimental data analysis. Artificial intelligence is particularly good at recognizing patterns in high dimensional…

Materials Science · Physics 2022-08-19 T. Tula , G. Möller , J. Quintanilla , S. R. Giblin , A. D. Hillier , E. E. McCabe , S. Ramos , D. S. Barker , S. Gibson

Acute lymphoblastic leukemia (ALL) is a form of blood cancer that affects the white blood cells. ALL constitutes approximately 25% of pediatric cancers. Early diagnosis and treatment of ALL are crucial for improving patient outcomes. The…

Image and Video Processing · Electrical Eng. & Systems 2024-07-16 Dimitris Papaioannou , Ioannis Christou , Nikos Anagnou , Aristotelis Chatziioannou

Lung cancer is a condition where there is abnormal growth of malignant cells that spread in an uncontrollable fashion in the lungs. Some common treatment strategies are surgery, chemotherapy, and radiation which aren't the best options due…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Ann Rachel , Pranav M Pawar , Mithun Mukharjee , Raja M , Tojo Mathew

Active surveillance (AS) is a suitable management option for newly-diagnosed prostate cancer (PCa), which usually presents low to intermediate clinical risk. Patients enrolled in AS have their tumor closely monitored via longitudinal…

Information flow analysis is a powerful technique for reasoning about the sensitive information exposed by a program during its execution. While past work has proposed information theoretic metrics (e.g., Shannon entropy, min-entropy,…

Cryptography and Security · Computer Science 2010-09-22 Ji Zhu , Mudhakar Srivatsa

Finding overcomplete latent representations of data has applications in data analysis, signal processing, machine learning, theoretical neuroscience and many other fields. In an overcomplete representation, the number of latent features…

Machine Learning · Computer Science 2021-06-10 Jesse A. Livezey , Alejandro F. Bujan , Friedrich T. Sommer

We apply modern methods in computational topology to the task of discovering and characterizing phase transitions. As illustrations, we apply our method to four two-dimensional lattice spin models: the Ising, square ice, XY, and…

Statistical Mechanics · Physics 2021-10-04 Alex Cole , Gregory J. Loges , Gary Shiu

The application of diffusion transformers is suffering from their significant inference costs. Recently, feature caching has been proposed to solve this problem by reusing features from previous timesteps, thereby skipping computation in…