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Many cellular functions are based on the rhythmic organization of biological processes into self-repeating cascades of events. Some of these periodic processes, such as the cell cycles of several species, exhibit conspicuous irregularities…

Molecular Networks · Quantitative Biology 2011-09-30 Pau Rué , Gürol M. Süel , Jordi Garcia-Ojalvo

We analyze the response of the Morris-Lecar model to a periodic train of short current pulses in the period-amplitude plane. For a wide parameter range encompassing both class 2 and class 3 behavior in Hodgkin's classification there is a…

Biological Physics · Physics 2023-07-19 L. S. Borkowski

The subthalamic nucleus (STN) has an important role in the pathophysiology of the basal ganglia in Parkinson's disease. The ability of STN cells to generate bursting rhythms under either transient or sustained hyperpolarization may underlie…

Neurons and Cognition · Quantitative Biology 2024-07-02 Choongseok Park , Leonid L. Rubchinsky , Sungwoo Ahn

Noise can induce coherent oscillations in excitable systems without periodic orbits. Here, we establish a method to derive a hybrid system approximating the noise-induced coherent oscillations in excitable systems and further perform phase…

Adaptation and Self-Organizing Systems · Physics 2022-05-26 Jinjie Zhu , Yuzuru Kato , Hiroya Nakao

We employ a typical genetic circuit model to explore how noise can influence the dynamic structure. With the increase of a key interactive parameter, the model will deterministically go through two bifurcations and three dynamic structure…

Biological Physics · Physics 2026-03-25 Yuxuan Wu , Yuxing Jiao , Yanzhen Zhao , Haojun Jia , Liufang Xu

We present a novel and global three-dimensional reduction of a non-dimensionalised version of the four-dimensional Hodgkin-Huxley equations [J. Rubin and M. Wechselberger, Giant squid--hidden canard: the 3D geometry of the Hodgkin-Huxley…

Dynamical Systems · Mathematics 2023-02-01 Panagiotis Kaklamanos , Nikola Popović , Kristian Uldall Kristiansen

Spiking Neural Networks (SNNs) are widely regarded as an energy-efficient paradigm for modeling and processing temporal and event-driven information. Incorporating delays in SNNs has been proven to be an effective mechanism for improving…

Machine Learning · Computer Science 2026-05-08 Dewei Bai , Hongxiang Peng , Yunyun Zeng , Ziyu Zhang , Hong Qu

We present a theory which is able to explain enhanced magnetic quantum-oscillation amplitudes in the superconducting state of a layered metal with incoherent electronic transport across the layers. The incoherence acts through the…

Superconductivity · Physics 2007-05-23 V. M. Gvozdikov , J. Wosnitza

We study the stability and information encoding capacity of synchronized states in a neuronal network model that represents part of thalamic circuitry. Our model neurons have a Hodgkin-Huxley-type low threshold Calcium channel, display post…

Statistical Mechanics · Physics 2007-05-23 P. H. E. Tiesinga , Jorge V. José

Spontaneous cortical population activity exhibits a multitude of oscillatory patterns, which often display synchrony during slow-wave sleep or under certain anesthetics and stay asynchronous during quiet wakefulness. The mechanisms behind…

Neurons and Cognition · Quantitative Biology 2018-06-20 Rodrigo F. O. Pena , Michael A. Zaks , Antonio C. Roque

We use tools of bifurcation theory to characterize dynamics of astrocytic~IP$_3$ and~Ca$^{2+}$ for different~IP$_3$ regimes from a mathematical point of view. We do so following a bottom-up approach, starting from a compact, well-stirred…

Neurons and Cognition · Quantitative Biology 2017-06-27 Valeri Matrosov , Susan Gordleeva , Natalia Boldyreva , Eshel Ben-Jacob , Alexey Semyanov , Victor Kazantsev , Maurizio De Pittà

Networks of fast-spiking interneurons are crucial for the generation of neural oscillations in the brain. Here we study the synchronous behavior of interneuronal networks that are coupled by delayed inhibitory and fast electrical synapses.…

Neurons and Cognition · Quantitative Biology 2012-06-22 Daqing Guo , Qingyun Wang , Matjaz Perc

A canard explosion is the dramatic change of period and amplitude of a limit cycle of a system of non-linear ODEs in a very narrow interval of the bifurcation parameter. It occurs in slow-fast systems and is well understood in singular…

Dynamical Systems · Mathematics 2015-06-17 Morten Brøns , Kristian Uldall Kristiansen

Large networks of sparsely coupled, excitatory and inhibitory cells occur throughout the brain. A striking feature of these networks is that they are chaotic. How does this chaos manifest in the neural code? Specifically, how variable are…

Neurons and Cognition · Quantitative Biology 2014-02-25 Guillaume Lajoie , Jean-Philippe Thivierge , Eric Shea-Brown

Serotonergic, noradrenergic and dopaminergic brainstem (including midbrain) neurons, often exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz, though dopaminergic and noradrenergic neurons only exhibit such…

Neurons and Cognition · Quantitative Biology 2017-04-18 Henry C. Tuckwell , Ying Zhou , Nicholas J. Penington

The folded node is a singularity associated with loss of normal hyperbolicity in systems where mixtures of slow and fast timescales arise due to singular perturbations. Canards are special solutions that reveal a counteractive feature of…

Dynamical Systems · Mathematics 2015-06-03 Mathieu Desroches , Mike R. Jeffrey

The influence of multiple vibrational modes on current fluctuations in electron transport through single-molecule junctions is investigated. Our analysis is based on a generic model of a molecular junction, which comprises a single…

Mesoscale and Nanoscale Physics · Physics 2014-09-26 C. Schinabeck , R. Härtle , H. B. Weber , M. Thoss

Human cognition emerges from coordinated spiking dynamics in distributed neural circuits, where information is encoded via both firing rates and precise spike timing determined by brain rhythms. Inspired by this notion, we propose a…

Neurons and Cognition · Quantitative Biology 2026-05-05 Tingting Dan , Guorong Wu

Observations of finely-timed spike relationships in population recordings have been used to support partial reconstruction of neural microcircuit diagrams. In this approach, fine-timescale components of paired spike train interactions are…

Neurons and Cognition · Quantitative Biology 2021-02-15 Jonathan Platkiewicz , Zachary Saccomano , Sam McKenzie , Daniel English , Asohan Amarasingham

We consider a finite system of interacting point processes with memory of variable length modeling a finite but large network of spiking neurons with two different leakage mechanisms. Associated to each neuron there are two point processes,…

Probability · Mathematics 2022-12-21 Kádmo de S. Laxa