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Biological systems, unlike physical or chemical systems, are characterized by the very inhomogeneous distribution of their components. The immune system, in particular, is notable for self-organizing its structure. Classically, the dynamics…

Statistical Mechanics · Physics 2007-05-23 Yoram Louzoun , Sorin Solomon , Henri Atlan , Irun R. Cohen

Cybersecurity attacks are a major and increasing burden to economic and social systems globally. Here we analyze the principles of security in different domains and demonstrate an architectural flaw in current cybersecurity. Cybersecurity…

Cryptography and Security · Computer Science 2013-03-13 Blake C. Stacey , Yaneer Bar-Yam

In recent years computer systems have become increasingly complex and consequently the challenge of protecting these systems has become increasingly difficult. Various techniques have been implemented to counteract the misuse of computer…

Artificial Intelligence · Computer Science 2010-07-05 Julie Greensmith , Uwe Aickelin , Jamie Twycross

Distributed system as e.g. artificial immune systems, complex adaptive systems, or multi-agent systems are widely used in Computer Science, e.g. for network security, optimisations, or simulations. In these systems, small entities move…

Multiagent Systems · Computer Science 2008-05-14 Michael Hilker

Biological systems, from cells to organisms, must respond to the ever changing environment in order to survive and function. This is not a simple task given the often random nature of the signals they receive, as well as the intrinsically…

Quantitative Methods · Quantitative Biology 2015-07-09 Aleksandra M. Walczak

The physical interpretation of the functioning of the adaptive immune system, which has been thoroughly characterized on genetic and molecular levels, provides a unique opportunity to define an adaptive self-organizing biological system in…

Molecular Networks · Quantitative Biology 2023-05-19 Jozsef Prechl

The phenomenon of immunological memory has been known for a long time. But, the underlying mechanism is poorly understood. According to the theory of clonal selection the response to a specific invading antigen (e.g., bacteria) is offered…

Statistical Mechanics · Physics 2007-05-23 Debashish Chowdhury

An immune system inspired Artificial Immune System (AIS) algorithm is presented, and is used for the purposes of automated program verification. Relevant immunological concepts are discussed and the field of AIS is briefly reviewed. It is…

Neural and Evolutionary Computing · Computer Science 2009-05-19 Soumya Banerjee

Crisis response requires information intensive efforts utilized for reducing uncertainty, calculating and comparing costs and benefits, and managing resources in a fashion beyond those regularly available to handle routine problems. This…

Multiagent Systems · Computer Science 2010-04-23 Khaled M. Khalil , M. Abdel-Aziz , Taymour T. Nazmy , Abdel-Badeeh M. Salem

Biological and artificial networks routinely make reliable distinctions between similar inputs, and the rules for making these distinctions are learned. In some ways, self/nonself discrimination in the immune system is similar, being both…

An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its…

Populations and Evolution · Quantitative Biology 2019-05-14 Andreas Mayer , Vijay Balasubramanian , Aleksandra M. Walczak , Thierry Mora

We consider the problem of designing synthetic cells to achieve a complex goal (e.g., mimicking the immune system by seeking invaders) in a complex environment (e.g., the circulatory system), where they might have to change their control…

Robotics · Computer Science 2020-03-10 Ana Pervan , Todd Murphey

In order to target threatening pathogens, the adaptive immune system performs a continuous reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell repertoire can evolve cells of increased specificity for the…

Populations and Evolution · Quantitative Biology 2022-03-23 Victor Chardès , Massimo Vergassola , Aleksandra M. Walczak , Thierry Mora

Denial of service attacks pose a threat in constant growth. This is mainly due to their tendency to gain in sophistication, ease of implementation, obfuscation and the recent improvements in occultation of fingerprints. On the other hand,…

Cryptography and Security · Computer Science 2024-02-13 Jorge Maestre Vidal , Ana Lucila Sandoval Orozco , Luis Javier García Villalba

Over the last decade, a new idea challenging the classical self-non-self viewpoint has become popular amongst immunologists. It is called the Danger Theory. In this conceptual paper, we look at this theory from the perspective of Artificial…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Steve Cayzer

A number of works in the field of intrusion detection have been based on Artificial Immune System and Soft Computing. Artificial Immune System based approaches attempt to leverage the adaptability, error tolerance, self- monitoring and…

Cryptography and Security · Computer Science 2012-05-22 Sugata Sanyal , Manoj Rameshchandra Thakur

The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the…

Populations and Evolution · Quantitative Biology 2009-11-11 Jun Sun , David J. Earl , Michael W. Deem

The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to the pathogenic environment to reduce the cost of infections. We develop a general…

Populations and Evolution · Quantitative Biology 2016-02-17 Andreas Mayer , Vijay Balasubramanian , Thierry Mora , Aleksandra M. Walczak

We model the immune surveillance of a pathogen which passes through $n$ immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be…

Populations and Evolution · Quantitative Biology 2010-05-04 Edgar Delgado-Eckert , Michael Shapiro

Biology has taken strong steps towards becoming a computer science aiming at reprogramming nature after the realisation that nature herself has reprogrammed organisms by harnessing the power of natural selection and the digital prescriptive…

Neural and Evolutionary Computing · Computer Science 2016-01-21 Hector Zenil , Angelika Schmidt , Jesper Tegnér