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Cytoskeletal networks of biopolymers are cross-linked by a variety of proteins. Experiments have shown that dynamic cross-linking with physiological linker proteins leads to complex stress relaxation and enables network flow at long times.…

We present a theoretical framework for the linear and nonlinear visco-elastic properties of reversibly crosslinked networks of semiflexible polymers. In contrast to affine models where network strain couples to the polymer end-to-end…

Soft Condensed Matter · Physics 2016-07-06 Jan Plagge , Andreas Fischer , Claus Heussinger

Transient networks comprised of polymers connected by short-lived bonds are a common design theme for both biological and synthetic materials. Transient bonds can provide mechanical rigidity, while still allowing for visco-elastic flows on…

Soft Condensed Matter · Physics 2019-01-02 Yuval Mulla , Gijsje H. Koenderink

We propose a theoretical framework for dealing with a transient polymer network undergoing small deformations, based on the rate of breaking and re-forming of network crosslinks and the evolving elastic reference state. In this framework,…

Soft Condensed Matter · Physics 2016-04-27 Fanlong Meng , Robyn H. Pritchard , Eugene M. Terentjev

A long standing puzzle in the rheology of living cells is the origin of the experimentally observed long time stress relaxation. The mechanics of the cell is largely dictated by the cytoskeleton, which is a biopolymer network consisting of…

Biological Physics · Physics 2021-10-04 Sihan Chen , Chase P. Broedersz , Tomer Markovich , Fred C. MacKintosh

We suggest a simple model for reversible cross-links, binding and unbinding to/from a network of semiflexible polymers. The resulting frequency dependent response of the network to an applied shear is calculated via Brownian dynamics…

Soft Condensed Matter · Physics 2018-08-17 Henry Amuasi , Andreas Fischer , Annette Zippelius , Claus Heussinger

We investigate theoretically the effect of polymer tension on the collective behavior of reversibly binding cross-links. For this purpose, we employ a model of two weakly bending wormlike chains aligned in parallel by a tensile force, with…

Biological Physics · Physics 2015-02-10 Panayotis Benetatos , Alice von der Heydt , Annette Zippelius

We perform equilibrium Langevin dynamics simulations to understand the structure-viscoelasticity relationship of a dually crosslinked reversible polymer network. The cross-linking is achieved by introducing orthogonal crosslinkers (A and B)…

Soft Condensed Matter · Physics 2023-11-01 Mounika Gosika , Angel J. Moreno

We study the elasticity of cross-linked networks of thermally fluctuating stiff polymers. As compared to their purely mechanical counterparts, it is shown that these thermal networks have a qualitatively different elastic response. By…

Soft Condensed Matter · Physics 2007-05-23 Claus Heussinger , Erwin Frey

The non-linear stress-strain relation for crosslinked polymer networks is studied using molecular dynamics simulations. Previously we demonstrated the importance of trapped entanglements in determining the elastic and relaxational…

Soft Condensed Matter · Physics 2009-10-31 Gary S. Grest , Mathias Puetz , Kurt Kremer , Ralf Everaers

Previous research on semiflexible polymers including cytoskeletal networks in cells has suggested the existence of distinct regimes of elastic response, in which the strain field is either uniform (affine) or non-uniform (non-affine) under…

Soft Condensed Matter · Physics 2009-11-11 D. A. Head , A. J. Levine , F. C. MacKintosh

The structure of polymer networks, defined by chain lengths and connectivity patterns, fundamentally influences their bulk properties. While existing polymer network models connect chain properties to emergent network behavior, they are…

Soft Condensed Matter · Physics 2026-03-17 Jason Mulderrig , Michael Buche , Matthew Grasinger

Recent experiments have demonstrated that the nonlinear elasticity of in vitro networks of the biopolymer actin is dramatically altered in the presence of a flexible cross-linker such as the abundant cytoskeletal protein filamin. The basic…

Soft Condensed Matter · Physics 2015-05-13 C. P. Broedersz , C. Storm , F. C. MacKintosh

Reversible crosslinking is a design paradigm for polymeric materials, wherein they are microscopically reinforced with chemical species that form transient crosslinks between the polymer chains. Besides the potential for self-healing,…

Soft Condensed Matter · Physics 2019-04-29 Nicholas B. Tito , Costantino Creton , Cornelis Storm , Wouter G. Ellenbroek

We study the structure and dynamics of a transient network composed of droplets of microemulsion connected by telechelic polymers. The polymer induces a bridging attraction between droplets without changing their shape. A viscoelastic…

Soft Condensed Matter · Physics 2009-10-31 F. Molino , J. Appell , M. Filali , E. Michel , G. Porte , S. Mora , E. Sunyer

This paper extends a field-theoretical dynamical networking formalism for mesoscopic polymer dynamics to explicitly include dedicated cross-linker particles. Cross-linkers are represented within a Martin-Siggia-Rose generating functional…

Soft Condensed Matter · Physics 2025-11-18 Nadine du Toit , Kristian K. Muller-Nedebock , Giuseppe Pellicane

Here, we provide an overview of theoretical approaches to semiflexible polymers and their networks. Such semiflexible polymers have large bending rigidities that can compete with the entropic tendency of a chain to crumple up into a random…

Soft Condensed Matter · Physics 2016-05-25 Chase P. Broedersz , Fred. C. MacKintosh

Motivated by recent experiments showing nonlinear elasticity of in vitro networks of the biopolymer actin cross-linked with filamin, we present an effective medium theory of flexibly cross-linked stiff polymer networks. We model such…

Soft Condensed Matter · Physics 2008-10-19 C. P. Broedersz , C. Storm , F. C. MacKintosh

We study two cross-linked polymer systems in the strong stretching regime. The first consists of two polymers sharing one endpoint, with the other two endpoints coupled by a harmonic potential. Within the weakly bending approximation, we…

Soft Condensed Matter · Physics 2026-03-30 Geunho Noh , Panayotis Benetatos

The cytoskeleton is an inhomogeneous network of semi-flexible filaments, which are involved in a wide variety of active biological processes. Although the cytoskeletal filaments can be very stiff and embedded in a dense and cross-linked…

Biological Physics · Physics 2019-05-24 Ines Weber , Cécile Appert-Rolland , Grégory Schehr , Ludger Santen
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