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Studies of biological solutions require high measurement accuracy, the ability to detect low changes in substance concentration, and small amounts of the liquid under test. A microwave complex permittivity measurement technique based on a…

The applications of nanomechanical resonators range from biomolecule mass sensing to hybrid quantum interfaces. Their performance is often limited by internal material damping, which can be greatly reduced by using crystalline materials.…

Mesoscale and Nanoscale Physics · Physics 2025-04-24 Leo Sementilli , Daniil M. Lukin , Hope Lee , Joshua Yang , Erick Romero , Jelena Vučković , Warwick P. Bowen

A flow-through sensing platform based on open-ended porous silicon (PSi) microcavity membranes that are compatible with integration in on-chip sensor arrays is demonstrated. Due to the high aspect ratio of PSi nanopores, the performance of…

Materials Science · Physics 2016-10-27 Yiliang Zhao , Girija Gaur , Scott T. Retterer , Paul E. Laibinis , Sharon M. Weiss

In this review article, we focus on emerging nanocantilever based biological sensors and discuss the response of nanocantilevers towards bio-molecules capture. The article guides the reader through various modes of operation (e.g., static…

Instrumentation and Detectors · Physics 2013-05-30 Ankit Jain , Muhammad Ashraful Alam

The successful detection of biomolecules by a Field Effect Transistor-based biosensor (BioFET) is dictated by the sensor's intrinsic Signal-to-Noise Ratio (SNR). The detection limit of a traditional BioFET is fundamentally limited by…

Applied Physics · Physics 2019-07-24 Nicolò Zagni , Paolo Pavan , Muhammad Ashraf Alam

Biological systems have been theoretically predicted to support phononic topological wave-modes, similar to the ones existing in meta-materials. The existing methods to measure these modes, however cannot be applied to biological systems;…

Biological Physics · Physics 2023-03-03 Ssu-Ying Chen , Arooj Aslam , David J. Apigo , Sagnik Basuray , Camelia Prodan

We have developed nano-scale double-gated field-effect-transistors for the study of electron states and transport properties of single deliberately-implanted phosphorus donors. The devices provide a high-level of control of key parameters…

Thin membranes are highly sought-after for nanopore-based single-molecule sensing and fabrication of such membranes becomes challenging in the \lesssim10 nm thickness regime where a plethora of useful molecule information can be acquired by…

Silicene (a monolayer of silicon atoms) is a quantum spin-Hall insulator, which undergoes a topological phase transition into other insulators by applying external field such as electric field, photo-irradiation and antiferromagnetic order.…

Mesoscale and Nanoscale Physics · Physics 2013-05-07 Motohiko Ezawa

We report on the development of 3D silicon sensors at the University of Science and Technology of China (USTC). The sensor involves columnar electrodes (5 um in diameter) of both doping types, etched from the same wafer side. The p+…

Instrumentation and Detectors · Physics 2026-05-14 Kuo Ma , De Zhang , Shengjia He , Tian-ao Wang , Han Li , Yu Nie , Xiuxia Wang , Jinlan Peng , Zheng Liang , Xiang Li , Wenhua Shi , Manwen Liu , Chuan Liao , Zheng Li , Zebo Tang , Yanwen Liu

We demonstrate a new, versatile class of nanoscale chemical sensors based on single-stranded DNA (ss-DNA) as the chemical sensors recognition site and single-walled carbon nanotube field effect transistors (swCN-FET) as the electronic…

Materials Science · Physics 2007-05-23 Cristian Staii , Michelle Chen , Alan Gelperin , Alan T. Johnson

Silicon nanowires have attracted considerable interest due to their wide-ranging applications in nanoelectromechanical systems and nanoelectronics. Molecular dynamics simulations are powerful tools for studying the mechanical properties of…

Materials Science · Physics 2023-08-25 Sina Zare Pakzad , Mohammad Nasr Esfahani , B. Erdem Alaca

Heller et. Al. (Science 311, 508 (2006)) demonstrated the first DNA-CN optical sensor by wrapping a piece of double-stranded DNA around the surface of single-walled carbon nanotubes (CN). This new type of optical device can be placed inside…

Mesoscale and Nanoscale Physics · Physics 2012-09-25 Anh D. Phan , Dustin A. Tracy , N. A. Viet

We describe a method with which to fabricate sub-micron mechanical structures from silicon-on-insulator substrates. We believe this is the first reported method for such fabrication, and our technique allows for complex, multilayer electron…

Mesoscale and Nanoscale Physics · Physics 2025-05-08 Andrew N. Cleland , Michael L. Roukes

Further development of quantum emitter based communication and sensing applications intrinsically depends on the availability of robust single-photon detectors. Here, we demonstrate a new generation of superconducting single-photon…

A novel nanostructured electrochemical immunsensor for the determination of progesterone is reported. The approach combines the properties of gold nanoparticles with the use of a graphite-Teflon composite electrode matrix, into which gold…

Materials Science · Physics 2007-08-13 J. -M. Pingarron , P. Yanez-Sedeno , A. Gonzalez-Cortes , V. Carralero

Absorption spectroscopy is widely used in sensing and astronomy to understand molecular compositions on microscopic to cosmological scales. However, typical dispersive spectroscopic techniques require multichannel detection, fundamentally…

Photonic crystals (PCs) with localized optical cavity modes arising from topological domain-wall line defects are simulated for optical biosensing by numerical solution of Maxwell's equations. These consist of a square lattice of square…

Optics · Physics 2026-01-06 Zhengzheng Zhai , Sajeev John

With the continuous development and improvement of medical services, there is a growing demand for improving diabetes diagnosis. Exhaled breath analysis, characterized by its speed, convenience, and non-invasive nature, is leading the trend…

Signal Processing · Electrical Eng. & Systems 2024-06-06 Jiaming Wei , Tong Liu , Jipeng Huang , Xiaowei Li , Yurui Qi , Gangyin Luo

Wearable, non-invasive glucose sensors capable of accurate and continuous monitoring are crucial for managing metabolic conditions yet achieving high sensitivity and stability in these devices remains challenging. In this work, we present a…

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