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Raman spectroscopy can provide insight into the molecular composition of cells and tissue. Consequently, it can be used as a powerful diagnostic tool, e.g. to help identify changes in molecular contents with the onset of disease. But robust…

Medical Physics · Physics 2023-08-02 Ciaran Bench , Mads S. Bergholt , Mohamed Ali al-Badri

Fluctuations in the measured mRNA levels of unperturbed cells under fixed conditions have often been viewed as an impediment to the extraction of information from expression profiles. Here, we argue that such expression fluctuations should…

Molecular Networks · Quantitative Biology 2007-05-23 William W. Chen , Jeremy L. England , Eugene I. Shakhnovich

While surface-based view synthesis algorithms are appealing due to their low computational requirements, they often struggle to reproduce thin structures. In contrast, more expensive methods that model the scene's geometry as a volumetric…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Christian Reiser , Stephan Garbin , Pratul P. Srinivasan , Dor Verbin , Richard Szeliski , Ben Mildenhall , Jonathan T. Barron , Peter Hedman , Andreas Geiger

The paradigm shift towards local and on-device inference under stringent resource constraints is represented by the tiny machine learning (TinyML) domain. The primary goal of TinyML is to integrate intelligence into tiny, low-cost devices…

The profile of suspended silicon nitride thin films patterned with one-dimensional subwavelength grating structures is investigated using Atomic Force Microscopy. We first show that the results of the profilometry can be used as input to…

Mesoscale and Nanoscale Physics · Physics 2021-02-18 Ali Akbar Darki , Alexios Parthenopoulos , Jens Vinge Nygaard , Aurélien Dantan

A common approach to quantifying DNA involves repeated cycles of DNA amplification. This approach, employed by the polymerase chain reaction (PCR), produces outputs that are corrupted by amplification noise, making it challenging to…

Quantitative Methods · Quantitative Biology 2023-01-06 Abdoelnaser M Degoot , Wilfred Ndifon

Machine learning models increasingly map biological sequence-fitness landscapes to predict mutational effects. Effective evaluation of these models requires benchmarks curated from empirical data. Despite their impressive scales, existing…

Machine Learning · Computer Science 2025-10-30 Mingyu Huang , Shasha Zhou , Ke Li

Scatterometry is a tested method for measuring periodic semiconductor structures. Since the sizes of modern semiconductor structures have reached the nanoscale regime, the challenge is to determine the shape of periodic nanostructures with…

Modern radio interferometers enable observations of spectral lines with unprecedented spatial resolution and sensitivity. In spite of these technical advances, many lines of interest are still at best weakly detected and therefore…

Instrumentation and Methods for Astrophysics · Physics 2018-04-25 Ryan A. Loomis , Karin I. Öberg , Sean M. Andrews , Catherine Walsh , Ian Czekala , Jane Huang , Katherine Rosenfeld

Micro-Doppler signatures contain considerable information about target dynamics. However, the radar sensing systems are easily affected by noisy surroundings, resulting in uninterpretable motion patterns on the micro-Doppler spectrogram.…

Signal Processing · Electrical Eng. & Systems 2022-05-04 Chong Tang , Wenda Li , Shelly Vishwakarma , Fangzhan Shi , Simon Julier , Kevin Chetty

Highly pixelated solid-state detectors offer outstanding capabilities in the identification and suppression of backgrounds from natural radioactivity. We present the background-identification strategies developed for the DAMIC experiment,…

Instrumentation and Detectors · Physics 2022-12-12 Alvaro E. Chavarria

Multisequence Magnetic Resonance Imaging (MRI) provides a more reliable diagnosis in clinical applications through complementary information across sequences. However, in practice, the absence of certain MR sequences is a common problem…

Image and Video Processing · Electrical Eng. & Systems 2025-10-21 Jihoon Cho , Jonghye Woo , Jinah Park

A novel solution is presented for the problem of estimating the backgrounds of a signal search using observed data while simultaneously maximizing the sensitivity of the search to the signal. The ``ABCD method'' provides a reliable…

High Energy Physics - Experiment · Physics 2025-06-11 CMS Collaboration

The high-throughput data generated by microarray experiments provides complete set of genes being expressed in a given cell or in an organism under particular conditions. The analysis of these enormous data has opened a new dimension for…

Computational Engineering, Finance, and Science · Computer Science 2012-11-12 Khalid Raza , Akhilesh Mishra

In astronomy, spectroscopy consists of observing an astrophysical source and extracting its spectrum of electromagnetic radiation. Once extracted, a model is fit to the spectra to measure the observables, leading to an understanding of the…

Motivated by the goals of dataset pruning and defect identification, a growing body of methods have been developed to score individual examples within a dataset. These methods, which we call "example difficulty scores", are typically used…

Machine Learning · Computer Science 2024-01-04 Devin Kwok , Nikhil Anand , Jonathan Frankle , Gintare Karolina Dziugaite , David Rolnick

Deep neural networks are vulnerable to adversarial examples, which dramatically alter model output using small input changes. We propose Neural Fingerprinting, a simple, yet effective method to detect adversarial examples by verifying…

Machine Learning · Computer Science 2019-06-18 Sumanth Dathathri , Stephan Zheng , Tianwei Yin , Richard M. Murray , Yisong Yue

This study presents an integrated approach for advancing functional Near-Infrared Spectroscopy (fNIRS) neuroimaging through the synthesis of data and application of machine learning models. By addressing the scarcity of high-quality…

Signal Processing · Electrical Eng. & Systems 2024-05-21 Eitan Waks

MicroRNAs (miRNAs) are non-coding RNAs with approximately 22 nucleotides (nt) that are derived from precursor molecules. These precursor molecules or pre-miRNAs often fold into stem-loop hairpin structures. However, a large number of…

Genomics · Quantitative Biology 2016-10-10 Ling Zhong , Jason T. L. Wang

Foreground-aware image synthesis aims to generate images as well as their foreground masks. A common approach is to formulate an image as an masked blending of a foreground image and a background image. It is a challenging problem because…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Jeongmin Bae , Mingi Kwon , Youngjung Uh