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Eukaryotic gene regulation is based on stochastic yet controlled promoter switching, during which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies reveal…

Molecular Networks · Quantitative Biology 2025-07-17 Benjamin Zoller , Alexis Bénichou , Thomas Gregor , Gašper Tkačik

Finding the optimal parameter setting (i.e. the optimal population size, the optimal mutation probability, the optimal evolutionary model etc) for an Evolutionary Algorithm (EA) is a difficult task. Instead of evolving only the parameters…

Neural and Evolutionary Computing · Computer Science 2021-09-29 Mihai Oltean , Crina Groşan

The co-design of robot morphology and neural control typically requires using reinforcement learning to approximate a unique control policy gradient for each body plan, demanding massive amounts of training data to measure the performance…

Robotics · Computer Science 2025-02-18 Luke Strgar , Sam Kriegman

Ecological systems show a variety of characteristic patterns of biodiversity in space and time. It is a challenge for theory to find models that can reproduce and explain the observed patterns. Since the advent of island biogeography these…

Populations and Evolution · Quantitative Biology 2019-10-21 Michaela Hamm , Barbara Drossel

The origin and organizing principles of the genetic code remain fundamental puzzles in life science. The vanishingly low probability of the natural codon-to-amino acid mapping arising by chance has spurred the hypothesis that its structure…

Other Quantitative Biology · Quantitative Biology 2025-10-14 Yudam Seo , Tsvi Tlusty , Junghyo Jo

Intragenomic recombination (crossover) is a very important evolutionary mechanism. The crossover events are not evenly distributed along the natural chromosomes. Monte Carlo simulations revealed that frequency of recombinations decides…

Genomics · Quantitative Biology 2009-01-13 Wojciech Waga , Marta Zawierta , Jakub Kowalski , Stanislaw Cebrat

Fine-tuning pre-trained language models, particularly large language models, demands extensive computing resources and can result in varying performance outcomes across different domains and datasets. This paper examines the approach of…

Computation and Language · Computer Science 2024-06-19 Guodong Du , Jing Li , Hanting Liu , Runhua Jiang , Shuyang Yu , Yifei Guo , Sim Kuan Goh , Ho-Kin Tang

The coding mechanism of sensory memory on the neuron scale is one of the most important questions in neuroscience. We have put forward a quantitative neural network model, which is self organized, self similar, and self adaptive, just like…

Neural and Evolutionary Computing · Computer Science 2014-06-26 Peilei Liu , Ting Wang

Evolutionary multitasking has recently emerged as a novel paradigm that enables the similarities and/or latent complementarities (if present) between distinct optimization tasks to be exploited in an autonomous manner simply by solving them…

Neural and Evolutionary Computing · Computer Science 2016-07-20 Abhishek Gupta , Yew-Soon Ong

The reaction-diffusion processes in a growing domain involves a dilution term that modifies the properties of the homogeneous state that, in contrast to a fixed domain, depends on time. We study how the dilution term changes the steady…

Pattern Formation and Solitons · Physics 2023-08-24 Aldo Ledesma-Durán

The adaptive evolution of large asexual populations is generally characterized by competition between clones carrying different beneficial mutations. This interference phenomenon slows down the adaptation speed and makes the theoretical…

Populations and Evolution · Quantitative Biology 2012-12-20 Maria Rita Fumagalli , Matteo Osella , Philippe Thomen , Francois Heslot , Marco Cosentino Lagomarsino

We study the probabilities of evolution based on random mutations and natural selection. We conclude that evolution to multicellular eukaryots, or even prokaryots, is unlikely to be the result of only random mutations. Complex organisms…

Populations and Evolution · Quantitative Biology 2007-05-23 B. Hoeneisen , G. Trueba

We characterize good clocks, which are naturally subject to fluctuations, in statistical terms. We also obtain the master equation that governs the evolution of quantum systems according to these clocks and find its general solution. This…

Quantum Physics · Physics 2009-10-31 Inigo L. Egusquiza , Luis J. Garay , Jose M. Raya

In evolutionary robotics, jointly optimising the design and the controller of robots is a challenging task due to the huge complexity of the solution space formed by the possible combinations of body and controller. We focus on the…

Robotics · Computer Science 2024-03-18 Léni K. Le Goff , Edgar Buchanan , Emma Hart

There are several forms of irreducibility in computing systems, ranging from undecidability to intractability to nonlinearity. This paper is an exploration of the conceptual issues that have arisen in the course of investigating speed-up…

Computational Complexity · Computer Science 2011-06-24 Hector Zenil , Fernando Soler-Toscano , Joost J. Joosten

This paper considers the behavior of discrete and continuous mathematical models for gene expression in the presence of transcriptional/translational bursting. We treat this problem in generality with respect to the distribution of the…

Probability · Mathematics 2015-10-15 M. C. Mackey , M. Tyran-Kamińska , R. Yvinec

Mixed microbial communities, usually composed of various bacterial and fungal species, are fundamental in a plethora of environments, from soil to human gut and skin. Their evolution is a paradigmatic example of intertwined dynamics, where…

Populations and Evolution · Quantitative Biology 2022-07-01 Andrea Roli , Stuart A. Kauffman

We considered a {multi-block} molecular model of biological evolution, in which fitness is a function of the mean types of alleles located at different parts (blocks) of the genome. We formulated an infinite population model with selection…

Populations and Evolution · Quantitative Biology 2015-06-12 David B. Saakian , Zara Kirakosyan , Chin-Kun Hu

Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution…

Populations and Evolution · Quantitative Biology 2015-06-12 Armita Nourmohammad , Stephan Schiffels , Michael Laessig

Lurking is a complex user-behavioral phenomenon that occurs in all large-scale online communities and social networks. It generally refers to the behavior characterizing users that benefit from the information produced by others in the…

Social and Information Networks · Computer Science 2016-05-23 Marco Alberto Javarone , Roberto Interdonato , Andrea Tagarelli