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Vertex Models, as used to describe cellular tissue, have an energy controlled by deviations of each cell area and perimeter from target values. The constrained nonlinear relation between area and perimeter leads to new mechanical response.…

Soft Condensed Matter · Physics 2022-07-04 Arthur Hernandez , Michael F. Staddon , Mark J. Bowick , M. Cristina Marchetti , Michael Moshe

We study computationally the creep and yielding of athermal gels and fibre network materials under a constant imposed shear stress, within a minimal model of interconnected filaments with central forces in $d=2$ spatial dimensions. Each…

Soft Condensed Matter · Physics 2026-01-23 Michael J. Hertaeg , Suzanne M. Fielding

Recently the materials possessing structure of molecular and supramolecular matrix are more and more actively studied. They are relative to many polymeric materials of a technological origin, such as rubber, and living biological tissues.…

Adaptation and Self-Organizing Systems · Physics 2013-06-27 A. A. Bedulina , A. V. Kobelev

Purpose: Hemolysis is a key issue in the design of blood-handling medical devices. Computational prediction of this phenomenon is challenging due to the complex multiscale nature of blood. As a result, conventional approaches often fail to…

Fluid Dynamics · Physics 2026-01-29 Nico Dirkes , Marek Behr

Recent experimental developments showed that the use of the radiation pressure, induced by a continuous laser wave, to control fluid-fluid interface deformations at the microscale, represents a very promising alternative to electric or…

Soft Condensed Matter · Physics 2010-07-26 Hamza Chraibi , Didier Lasseux , Régis Wunenburger , Eric Arquis , Jean-Pierre Delville

Fracture resistance of blood clots plays a crucial role in physiological hemostasis and pathological thromboembolism. Although recent experimental and computational studies uncovered the poro-viscoelastic property of blood clots and its…

Medical Physics · Physics 2024-06-26 Dongxu Liu , Nhung Nguyen , Tinh Quoc Bui , Luka Pocivavsek

Motivated by rolling adhesion of white blood cells in the vasculature, we study how cells move in linear shear flow above a wall to which they can adhere via specific receptor-ligand bonds. Our computer simulations are based on a Langevin…

Cell Behavior · Quantitative Biology 2008-04-30 C. B. Korn , U. S. Schwarz

We apply a recently developed model of cytoskeletal force generation to study a cell intrinsic contractility, as well as its response to external loading. The model is based on a non-equilibrium thermodynamic treatment of the…

Subcellular Processes · Quantitative Biology 2015-06-19 Mirko Maraldi , Clara Valero , Krishna Garikipati

Molecular dynamics simulations are performed to examine the dynamic response of amorphous solids to oscillatory shear at finite temperatures. The data were collected from a poorly annealed binary glass, which was deformed periodically in…

Soft Condensed Matter · Physics 2017-11-21 Nikolai V. Priezjev

We present an analytical theory for heteropolymer deformation, as exemplified experimentally by stretching of single protein molecules. Using a mean-field replica theory, we determine phase diagrams for stress-induced unfolding of typical…

Statistical Mechanics · Physics 2009-11-07 Phillip L. Geissler , Eugene I. Shakhnovich

It is stated in the main in essence new approach to mechanics of the stressed state of the solid body from statistically isotropic material and the homogeneous liquid dynamics. The approach essence is in the detected property of the…

Fluid Dynamics · Physics 2008-09-25 S. L. Arsenjev

We use a minimal model for a dense suspension undergoing thickening and thinning to investigate microstructural changes in 2d simulations. Our simulations show that in steady flow the contact network contains distinct building blocks which…

Soft Condensed Matter · Physics 2026-04-15 William C. J. Buchholtz , Daniel L. Blair , Jeffrey S. Urbach , H. A. Vinutha , Emanuela Del Gado

We construct a homogeneous, nonlinear elastic constitutive law, that models aspects of the mechanical behavior of inhomogeneous fibrin networks. Fibers in such networks buckle when in compression. We model this as a loss of stiffness in…

Biological Physics · Physics 2015-12-18 Phoebus Rosakis , Jacob Notbohm , Guruswami Ravichandran

We report a dynamical-mechanical study of stress relaxation at small deformation in a natural (polyisoprene) rubber well above its glass transition temperature Tg. We find that an almost complete relaxation of stress takes place over very…

Soft Condensed Matter · Physics 2009-10-31 S. M. Clarke , F. Elias , E. M. Terentjev

Many organisms have an elastic skeleton that consists of a closed shell of epithelial cells that is filled with fluid, and can actively regulate both elastic forces in the shell and hydrostatic pressure inside it. In this work we introduce…

Soft Condensed Matter · Physics 2023-10-13 Ajoy Maji , Yitzhak Rabin

Results on the rheological behavior of novel CHO cell suspensions in a large range of concentrations are reported. The concentration dependent yield stress and elastic plateau modulus are formalized in the context of fractal aggregates…

Soft Condensed Matter · Physics 2009-11-13 Andreea Iordan , Alain Duperray , Claude Verdier

Two-dimensional (2D) mechanical models of confluent tissues have related the mechanical state of a monolayer of cells to the average perimeter length of the cell cross sections, predicting floppiness or rigidity of the material. For the…

Soft Condensed Matter · Physics 2025-01-30 Jairo M. Rojas , Mayisha Z. Nakib , Vivian W. Tang , William M. Brieher , Sascha Hilgenfeldt

We show that the slow viscoelastic response of a foam is that of a power-law fluid with a terminal relaxation. Investigations of the foam mechanics in creep and recovery tests reveal that the power-law contribution is fully reversible,…

Soft Condensed Matter · Physics 2022-05-09 François A. Lavergne , Peter Sollich , Véronique Trappe

Light forces induced by scattering and absorption in elastic dielectrics lead to local density modulations and deformations. These perturbations in turn modify light propagation in the medium and generate an intricate nonlinear response. We…

Optics · Physics 2012-11-01 Matthias Sonnleitner , Monika Ritsch-Marte , Helmut Ritsch

Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear stresses inside living tissue. The mechanisms that govern the transmission of mechanical forces in epithelia and the collective response of the tissue…

Soft Condensed Matter · Physics 2022-11-29 Junxiang Huang , James O. Cochran , Suzanne M. Fielding , M. Cristina Marchetti , Dapeng Bi