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The United Nations (UN) issued official probabilistic population projections for all countries to 2100 in July 2015. This was done by simulating future levels of total fertility and life expectancy from Bayesian hierarchical models, and…

Applications · Statistics 2016-09-15 David J. Sharrow , Jessica Godwin , Yanjun He , Samuel J. Clark , Adrian E. Raftery

While probabilistic projection methods for projecting life expectancy exist, few account for covariates related to life expectancy. Generalized HIV/AIDS epidemics have a large, immediate negative impact on the life expectancy in a country,…

Applications · Statistics 2016-09-28 Jessica Godwin , Adrian E. Raftery

Planning, implementation and evaluation of public health policies to control the human immunodeficiency virus (HIV) epidemic require regular monitoring of disease burden. This includes the proportion living with HIV, whether diagnosed or…

Methodology · Statistics 2014-05-20 Daniela De Angelis , Anne M. Presanis , Stefano Conti , A. E. Ades

Multi-parameter evidence synthesis (MPES) is receiving growing attention from the epidemiological community as a coherent and flexible analytical framework to accommodate a disparate body of evidence available to inform disease incidence…

Understanding historical trends in the epidemic of HIV is important for assessing current and projecting future trends in prevalence, incidence and mortality and for evaluating the impact and cost-effectiveness of control measures. In…

Quantitative Methods · Quantitative Biology 2014-12-10 Brian G. Williams

Ending the HIV/AIDS pandemic is among the Sustainable Development Goals for the next decade. In order to overcome the gap between the need for care and the available resources, better understanding of HIV epidemics is needed to guide policy…

Applications · Statistics 2020-09-03 Zhou Lan , Le Bao

Unintended pregnancy and abortion estimates are needed to inform and motivate investment in global health programmes and policies. Variability in the availability and reliability of data poses challenges for producing estimates. We…

Key populations at high risk of HIV infection are critical for understanding and monitoring HIV epidemics, but global estimation is hampered by sparse, uneven data. We analyze data from 199 countries for female sex workers (FSW), men who…

Applications · Statistics 2025-09-16 Jiahao Zhang , Keith Sabin , Le Bao

Local estimates of HIV-prevalence provide information that can be used to target interventions and consequently increase the efficiency of the resources. This closer-to-optimal allocation can lead to better health outcomes, including the…

Applications · Statistics 2023-07-18 Enrique M. Saldarriaga

The United Nations regularly publishes projections of the populations of all the world's countries broken down by age and sex. These projections are the de facto standard and are widely used by international organizations, governments and…

Methodology · Statistics 2014-05-20 Adrian E. Raftery , Leontine Alkema , Patrick Gerland

As the global HIV pandemic enters its fourth decade, increasing numbers of surveillance sites have been established which allows countries to look into the epidemics at a finer scale, e.g. at sub-national levels. Currently, the epidemic…

Applications · Statistics 2015-08-27 Le Bao , Xiaoyue Niu , Mary Mahy , Peter D. Ghys

Cross-sectional HIV incidence estimation leverages recency test results to determine the HIV incidence of a population of interest, where recency test uses biomarker profiles to infer whether an HIV-positive individual was "recently"…

Methodology · Statistics 2023-11-21 Qi Wang , Ann Duerr , Fei Gao

Like many chronic diseases, human immunodeficiency virus (HIV) is managed over time at regular clinic visits. At each visit, patient features are assessed, treatments are prescribed, and a subsequent visit is scheduled. There is a need for…

Methodology · Statistics 2024-10-31 Arman Oganisian , Joseph Hogan , Edwin Sang , Allison DeLong , Ben Mosong , Hamish Fraser , Ann Mwangi

Estimating the number of the number of people from hidden and/or marginalised populations - such as people dependent on opioids or cocaine - is important to guide policy decisions and provision of harm reduction services. Methods such as…

The past decade has seen tremendous progress in the development of biomedical agents that are effective as pre-exposure prophylaxis (PrEP) for HIV prevention. To expand the choice of products and delivery methods, new medications and…

Methodology · Statistics 2020-11-03 Fei Gao , David V. Glidden , James P. Hughes , Deborah Donnell

Cross-sectional incidence estimation based on recency testing has become a widely used tool in HIV research. Recently, this method has gained prominence in HIV prevention trials to estimate the "placebo" incidence that participants might…

Methodology · Statistics 2024-12-18 Jianan Pan , Marlena Bannick , Fei Gao

Pre-exposure prophylaxis (PrEP) consists in the use of an antiretroviral medication to prevent the acquisition of HIV infection by uninfected individuals and has recently demonstrated to be highly efficacious for HIV prevention. We propose…

Optimization and Control · Mathematics 2017-10-12 Cristiana J. Silva , Delfim F. M. Torres

Network surveys of key populations at risk for HIV are an essential part of the effort to understand how the epidemic spreads and how it can be prevented. Estimation of population values from the sample data has been probematical, however,…

Applications · Statistics 2019-09-12 Steve Thompson

Pathogen deep-sequencing is an increasingly routinely used technology in infectious disease surveillance. We present a semi-parametric Bayesian Poisson model to exploit these emerging data for inferring infectious disease transmission flows…

Applications · Statistics 2022-01-06 Xiaoyue Xi , Simon EF Spencer , Matthew Hall , M Kate Grabowski , Joseph Kagaayi , Oliver Ratmann

Accurate HIV incidence estimation based on individual recent infection status (recent vs long-term infection) is important for monitoring the epidemic, targeting interventions to those at greatest risk of new infection, and evaluating…

Methodology · Statistics 2021-04-13 Ben Sheng , Changcheng Li , Le Bao , Runze Li
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