Related papers: Borges Dilemma, Fundamental Laws, and Systems Biol…
The law of likelihood underlies a general framework, known as the likelihood paradigm, for representing and interpreting statistical evidence. As stated, the law applies only to simple hypotheses, and there have been reservations about…
As the frontiers of biology become increasingly interdisciplinary, the physics education community has engaged in ongoing efforts to make physics classes more relevant to life sciences majors. These efforts are complicated by the many…
Biological organisms are composed of numerous interconnected biochemical processes. Diseases occur when normal functionality of these processes is disrupted. Thus, understanding these biochemical processes and their interrelationships is a…
A notion of biologic system or just a system implies a functional wholeness of comprising system components. Positive and negative feedback are the examples of how the idea to unite anatomical elements in the whole functional structure was…
Popular multiverse models such as the one based on the string theory landscape require an underlying set of unexplained laws containing many specific features and highly restrictive prerequisites. I explore the consequences of relaxing some…
Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…
The grand challenges in biology today are being shaped by powerful high-throughput technologies that have revealed the genomes of many organisms, global expression patterns of genes and detailed information about variation within…
Explaining biodiversity in nature is a fundamental problem in ecology. An outstanding challenge is embodied in the so-called Competitive Exclusion Principle: two species competing for one limiting resource cannot coexist at constant…
The rapidly increasing interest in the quantum properties of living matter stimulates a discussion of the fundamental properties of life as well as quantum mechanics. In this discussion often concepts are used that originate in philosophy…
The origin of life is often framed primarily as a chemical problem, yet life's defining feature is evolution. Advances in geochemistry, prebiotic chemistry, and molecular biology have produced diverse scenarios for the emergence of genomes,…
The present paper addresses several puzzles related to the Rule of Existential Generalization, (EG). In solution to these puzzles from the viewpoint of simple type theory, I distinguish (EG) from a modified Rule of Existential Quantifier…
Living organisms are not just random collections of organic molecules. There is continuous information processing going on in the apparent bouncing around of molecules of life. Optimisation criteria in this information processing can be…
The principle of the common cause claims that if an improbable coincidence has occurred, there must exist a common cause. This is generally taken to mean that positive correlations between non-causally related events should disappear when…
Classical confidence limits are compared to Bayesian error bounds by studying relevant examples. The performance of the two methods is investigated relative to the properties coherence, precision, bias, universality, simplicity. A proposal…
Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key…
A qualitatively new, much more liberal and efficient organisation of science is proposed and justified, in connection with growing debate about further role and development of fundamental science. Although the key ideas can be explained…
Quantum Biology is emerging as a new field at the intersection between fundamental physics and biology, promising novel insights into the nature and origin of biological order. We discuss several elements of QBCL (Quantum Biology at…
The generally accepted wisdom in computational circles is that pure proof verification is a solved problem and that the computationally hard elements and fertile areas of study lie in proof discovery. This wisdom presumably does hold for…
The discipline of `theoretical biology' has been developing from its inception several decades ago almost in parallel with the advances in biology, so much so that the latter is often considered to be almost exclusively an empirical…
In ordinary situations involving a small part of the universe, Born's rule seems to work well for calculating probabilities of observations in quantum theory. However, there are a number of reasons for believing that it is not adequate for…