Related papers: Borges Dilemma, Fundamental Laws, and Systems Biol…
Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…
The Central Dogma of molecular biology, as originally proposed by Crick, asserts that information passed into protein cannot flow back out. This principle has been interpreted as underpinning modern understandings of heredity and evolution,…
We reveal a duality in classical and quantum mechanics. Dual systems are related by duality transforms. All mechanical systems that are dual to each other form a duality family. In a duality family, once a system is solved, all other…
While fields like Artificial Life have made huge strides in quantifying the mechanisms that distinguish living systems from non-living ones, particular mechanisms remain difficult to reproduce in silico. Known as open-endedness, we've been…
In the Bayesian approach to probability theory, probability quantifies a degree of belief for a single trial, without any a priori connection to limiting frequencies. In this paper we show that, despite being prescribed by a fundamental…
I think that the main reason why we do not understand the general principles of how knowledge works (and probably also the reason why we have not yet designed and built efficient machines capable of artificial intelligence), is not the…
It has recently been shown that the marginalization paradox (MP) can be resolved by interpreting improper inferences as probability limits. The key to the resolution is that probability limits need not satisfy the formal Bayes' law, which…
In making models for biological systems one expects to grasp the biology and be able to use ones intuition to predict the outcome. This paper is about the discrepancy between what is expected and what is the outcome of the analysis of the…
The advent of molecular biology has led to the identification of definitive causative factors for a number of diseases, most of which are monogenic. Causes for most common diseases across the population, however, seem elusive and cannot be…
We critically analyse the point of view for which laws of nature are just a mean to compress data. Discussing some basic notions of dynamical systems and information theory, we show that the idea that the analysis of large amount of data by…
Molecular biology is a nanotechnology that works--it has worked for billions of years and in an amazing variety of circumstances. At its core is a system for acquiring, processing and communicating information that is universal, from…
Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms.…
Study on pre- and postselected quantum system indicates that ``product rule'' and ``sum rule'' for elements of reality should be abandoned. We show that this so-called non-partial realism can refute arguments against hidden variables in a…
After surveying classical results, we introduce a generalized notion of inference system to support structural recursion on non-well-founded data types. Besides axioms and inference rules with the usual meaning, a generalized inference…
The problematic relationship between science and philosophy has, since the beginning of modernity, divided the world into two separate domains: nature and human. Some of today's schools of philosophy and epistemological inquiry have…
A vast body of literature addresses the complex nature of science's reproducibility crisis. In contrast with this perceived complexity, some recent papers from the discipline of physics suggests that irreproducibility does not point to a…
Life occurs in concentrated `Ringer Solutions' derived from seawater that Lesser Blum studied for most of his life. As we worked together, Lesser and I realized that the questions asked of those solutions were quite different in biology…
Well protected human and laboratory animal populations with abundant resources are evolutionary unprecedented, and their survival far beyond reproductive age may be a byproduct rather than tool of evolution. Physical approach, which takes…
The probability that life spontaneously emerges in a suitable environment (abiogenesis) is one of the major unknowns in astrobiology. Assessing its value is impeded by the lack of an accepted theory for the origin of life, and is further…
The principle of classification of macroprocesses is offered, which allows to avoid some methodological mistakes of modern natural sciences. The content and the nearest consequences of this principle is open and its conformity of a…