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We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer…

Biomolecules · Quantitative Biology 2015-06-26 T. Ambjoernsson , M. A. Lomholt , R. Metzler

We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic…

Soft Condensed Matter · Physics 2009-11-10 Ulrich Gerland , Ralf Bundschuh , Terence Hwa

Single file translocation of a homopolymer through an active channel under the presence of a driving force is studied using Langevin dynamics simulation. It is shown that a channel with sticky walls and oscillating width could lead to…

Soft Condensed Matter · Physics 2013-02-01 Jack A. Cohen , Abhishek Chaudhuri , Ramin Golestanian

One of the major theoretical methods in understanding polymer translocation through a nanopore is the Fokker-Planck formalism based on the assumption of quasi-equilibrium of polymer conformations. The criterion for applicability of the…

Soft Condensed Matter · Physics 2018-02-14 Harshwardhan H. Katkar , Murugappan Muthukumar

We study the first passage time for a polymer, that we call the narrow encounter time (NETP), to reach a small target located on the surface of a microdomain. The polymer is modeled as a Freely Joint Chain (beads connected by springs with a…

Soft Condensed Matter · Physics 2015-06-12 A. Amitai , Carlo Amoruso , Avi Ziskind , D. Holcman

We consider the dynamics of a translocation process of a flexible linear polymer through a nanopore into an environment of active rods in the {\it trans} side. Using Langevin dynamics simulations we find that the rods facilitate…

Soft Condensed Matter · Physics 2022-11-15 Hamidreza Khalilian , Jalal Sarabadani , Tapio Ala-Nissila

We present an analysis of a partially directed walk model of a polymer which at one end is tethered to a sticky surface and at the other end is subjected to a pulling force at fixed angle away from the point of tethering. Using the kernel…

Soft Condensed Matter · Physics 2015-05-19 Judy-anne Osborn , Thomas Prellberg

Motivated by the experiments on DNA under torsion, we consider the problem of pulling a polymer out of a potential well by a force applied to one of its ends. If the force is less than a critical value, then the process is activated and has…

Soft Condensed Matter · Physics 2009-10-31 K. L. Sebastian

Langevin dynamics simulations are performed to investigate ejection dynamics of spherically confined flexible polymers through a pore. By varying the chain length $N$ and the initial volume fraction $\phi_0$ of the monomers, two scaling…

Soft Condensed Matter · Physics 2020-01-29 Hao-Chun Huang , Pai-Yi Hsiao

In an earlier preprint (V. V. Ginzburg, O. V. Gendelman, R. Casalini, and A. Zaccone, arxiv:2409.17291), we demonstrated that the dynamic (relaxation time) and volume equations of state for many amorphous polymers are near-universal -- each…

Soft Condensed Matter · Physics 2025-01-03 Valeriy V. Ginzburg , Oleg V. Gendelman , Riccardo Casalini , Alessio Zaccone

In this paper we consider a model which describes a polymer chain interacting with an infinity of equi-spaced linear interfaces. The distance between two consecutive interfaces is denoted by T = T_N and is allowed to grow with the size N of…

Probability · Mathematics 2009-01-20 Francesco Caravenna , Nicolas Pétrélis

When injected through a contraction, high molecular weight polymer solutions exhibit a sharp increase of apparent viscosity which originates from stretching polymer chains above a critical extension rate. This chain stretching can also…

Fluid Dynamics · Physics 2020-04-22 Sandeep Garrepally , Stephane Jouenne , Peter D. Olmsted , Francois Lequeux

This paper studies the features of a homopolymer translocating through a flexible pore. The channel is modeled as a monolayer tube composed by monomers with two elastic parameters: spring-like two body interaction and bending three body…

Soft Condensed Matter · Physics 2022-11-01 A. Fiasconaro , G. Diez-Senorans , F. Falo

The translocation of a macromolecule through a nanometer-sized pore is an interesting process with important applications in the development of biosensors for single--molecule analysis and in drug delivery and gene therapy. We have carried…

Statistical Mechanics · Physics 2009-09-29 Yves Lansac , Prabal K. Maiti , Matthew A. Glaser

Stretched polymers with attractive interaction are studied in two and three dimensions. They are described by biased self-avoiding random walks with nearest neighbour attraction. The bias corresponds to opposite forces applied to the first…

Statistical Mechanics · Physics 2009-11-07 Peter Grassberger , Hsiao-Ping Hsu

Knotted proteins, when forced through the pores, can get stuck if the knots in their backbone tighten under force. Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model…

Statistical Mechanics · Physics 2023-11-08 Karol Capała , Piotr Szymczak

Polymer-coated pores play a crucial role in nucleo-cytoplasmic transport and in a number of biomimetic and nanotechnological applications. Here we present Monte Carlo and Density Functional Theory approaches to identify different collective…

Soft Condensed Matter · Physics 2015-05-30 Dino Osmanovic , Joe Bailey , Anthony H. Harker , Ariberto Fassati , Bart W. Hoogenboom , Ian J. Ford

Polymer solutions are often injected in porous media for applications such as oil recovery and groundwater remediation. As the fluid navigates the tortuous pore space, elastic stresses build up, causing the flow to become unstable at…

Soft Condensed Matter · Physics 2020-04-22 Christopher A. Browne , Audrey Shih , Sujit S. Datta

We show in detail some results, outlined in a previous paper regarding the case of Brownian motion (BM), about the distribution of the $n$th-passage time of a one-dimensional diffusion obtained by a space or time transformation of BM,…

Probability · Mathematics 2018-04-12 Mario Abundo , Maria Beatrice Scioscia Santoro

The mechanical properties of polymer knots under stretching in a bad or good solvent are investigated by applying a given force $F$ to a point of the knot while keeping another point fixed. The Monte Carlo sampling of the polymer…

Soft Condensed Matter · Physics 2015-12-15 Yani Zhao , Franco Ferrari