Related papers: Global and regional brain metabolic scaling and it…
Generative AI has recently propelled the decoding of images from brain activity. How do these approaches scale with the amount and type of neural recordings? Here, we systematically compare image decoding from four types of non-invasive…
Grid cells in the entorhinal cortex fire when animals that are exploring a certain region of space occupy the vertices of a triangular grid that spans the environment. Different neurons feature triangular grids that differ in their…
The human brains are organized into hierarchically modular networks facilitating efficient and stable information processing and supporting diverse cognitive processes during the course of development. While the remarkable reconfiguration…
Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta- and mega-analyses…
The universal scaling law of cortical morphology describes cortical folding as the covariance of average grey matter thickness, pial surface area, and exposed surface area. It applies for mammalian species, humans, and across lobes, however…
Brain-body co-optimization remains a challenging problem, despite increasing interest from the community in recent years. To understand and overcome the challenges, we propose exhaustively mapping a morphology-fitness landscape to study it.…
We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks. Using this approach, we are able to write a large metabolic network in a systematic and compact way. We demonstrate…
Integrated global food system analysis is hampered by the fragmentation of data among food types, processes, and scales. Studies also often neglect the connection to human metabolism -- the ultimate driver of food demand. Here we use a…
Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but $\textit{in vivo}$ studies on this matter…
Results of an experiment are presented whose aim is to explore the relationship between respiration and cerebral oxygenation. Measurements of end tidal CO2 (EtCO2) were taken simultaneously with cerebral oxygen saturation (rSO2) using the…
Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…
Metabolism and evolution are closely connected: if a mutation incurs extra energetic costs for an organism, there is a baseline selective disadvantage that may or may not be compensated for by other adaptive effects. A long-standing, but to…
Computation of biological processes creates great promise for everyday life and great challenges for physical scientists. Simulations of molecular dynamics appeal to biologists as a natural extension of structural biology. Once biologists…
At large, most animal brains present two mirror-symmetric sides; but closer inspection reveals a range of asymmetries (in shape and function), that seem more salient in more cognitively complex species. Sustaining symmetric, redundant…
This paper investigates how neurons can use metabolic cost to facilitate learning at a population level. Although decision-making by individual neurons has been extensively studied, questions regarding how neurons should behave to cooperate…
Background & Aims: Patients with type C hepatic encephalopathy (HE) present diverse symptoms indicating that various brain regions are affected. Understanding the distinct metabolic and cellular changes across these regions could help…
White matter in mammal brains forms a densely interconnected communication network. Due to high edge density, along with continuous generation and spread of messages, brain networks must contend with congestion, which may limit polysynaptic…
The human brain exhibits a complex structure made of scale-free highly connected modules loosely interconnected by weaker links to form a small-world network. These features appear in healthy patients whereas neurological diseases often…
Multiple studies of neural avalanches across different data modalities led to the prominent hypothesis that the brain operates near a critical point. The observed exponents often indicate the mean-field directed-percolation universality…
It is well established that the brain spontaneously traverses through a very large number of states. Nevertheless, despite its relevance to understanding brain function, a formal description of this phenomenon is still lacking. To this end,…