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Synthetic bio-molecular spiders with "legs" made of single-stranded segments of DNA can move on a surface covered by single-stranded segments of DNA called substrates when the substrate DNA is complementary to the leg DNA. If the motion of…

Biological Physics · Physics 2015-06-04 Tibor Antal , P. L. Krapivsky

Molecular spiders are synthetic bio-molecular systems which have "legs" made of short single-stranded segments of DNA. Spiders move on a surface covered with single-stranded DNA segments complementary to legs. Different mappings are…

Statistical Mechanics · Physics 2007-08-25 Tibor Antal , P. L. Krapivsky , Kirone Mallick

Molecular spiders are synthetic molecular motors based on DNA nanotechnology. While natural molecular motors have evolved towards very high efficiency, it remains a major challenge to develop efficient designs for man-made molecular motors.…

Biological Physics · Physics 2013-03-11 Matthias Rank , Louis Reese , Erwin Frey

Molecular spiders are synthetic catalytic DNA-based nanoscale walkers. We study the mean first passage time for abstract models of spiders moving on a finite two-dimensional lattice with various boundary conditions, and compare it with the…

Biological Physics · Physics 2014-12-02 Oleg Semenov , David Mohr , Darko Stefanovic

We study the motion of random walkers with residence time bias between first and subsequent visits to a site, as a model for synthetic molecular walkers composed of coupled DNAzyme legs known as molecular spiders. The mechanism of the…

Biological Physics · Physics 2020-07-01 David Arredondo , Darko Stefanovic

Spider walks are systems of interacting particles. The particles move independently as long as their movement do not violate some given rules describing the relative position of the particles; moves that violate the rules are not realized.…

Probability · Mathematics 2010-03-18 Christophe Gallesco , Sebastian Müller , Serguei Popov

A simple symmetric random walk is considered on a spider that is a collection of half lines (we call them legs) joined at the origin. We establish a strong approximation of this random walk by the so-called Brownian spider. Transition…

Probability · Mathematics 2015-07-02 Endre Csáki , Miklós Csörgő , Antonia Földes , Pál Révész

Self-repelling two-leg (biped) spider walk is considered where the local stochastic movements are governed by two independent control parameters $ \beta_d$ and $ \beta_h $, so that the former controls the distance ($ d $) between the legs…

Statistical Mechanics · Physics 2021-12-08 H. Dashti N. , M. N. Najafi , Hyunggyu Park

A spider consists of several, say $N$, particles. Particles can jump independently according to a random walk if the movement does not violate some given restriction rules. If the movement violates a rule it is not carried out. We consider…

Probability · Mathematics 2015-03-13 Christophe Gallesco , Sebastian Muller , Serguei Popov , Marina Vachkovskaia

A simple random walk and a Brownian motion are considered on a spider that is a collection of half lines (we call them legs) joined in the origin. We give a strong approximation of these two objects and their local times. For fixed number…

Probability · Mathematics 2017-05-12 Endre Csaki , Miklos Csorgo , Antonia Foldes , Pal Revesz

Artificial nanowalkers are inspired by biomolecular counterparts from living cells, but remain far from comparable to the latter in design principles. The walkers reported to date mostly rely on chemical mechanisms to gain a direction; they…

Orb-weaving spiders detect prey on a web using vibration sensors at leg joints. They often dynamically crouch their legs during prey sensing, likely an active sensing strategy. However, how leg crouching enhances sensing is poorly…

Robotics · Computer Science 2026-01-26 Siyuan Sun , Eugene H. Lin , Nathan Brown , Hsin-Yi Hung , Andrew Gordus , Jochen Mueller , Chen Li

Understanding the motion of particles with ligand-receptors is important for biomedical applications and material design. Yet, even among a single design, the prototypical DNA-coated colloids, seemingly similar micrometric particles hop or…

Soft Condensed Matter · Physics 2023-10-31 Jeana Aojie Zheng , Miranda Holmes-Cerfon , David J. Pine , Sophie Marbach

We consider a simple symmetric random walk on a spider, that is a collection of half lines (we call them legs) joined at the origin. Our main question is the following: if the walker makes $n$ steps how high can he go up on all legs. This…

Probability · Mathematics 2014-02-25 Antonia Foldes , Pal Revesz

Colloidal particles with DNA `legs' that can bind reversibly to receptors on a surface can be made to `walk' if there is a gradient in receptor concentration. We use a combination of theory and Monte Carlo simulations to explore how…

Orb-weaving spiders primarily sense leg vibrations to detect and locate prey caught on their wheel-shaped webs. Biological experiments and computational modeling elucidated the physics of how these spiders use long-timescale web-building…

Biological Physics · Physics 2025-12-29 Eugene H. Lin , Yishun Zhou , Hsin-Yi Hung , Luke Moon , Andrew Gordus , Chen Li

Particles with ligand-receptor contacts bind and unbind fluctuating "legs" to surfaces, whose fluctuations cause the particle to diffuse. Quantifying the diffusion of such "nanoscale caterpillars" is a challenge, since binding events often…

Soft Condensed Matter · Physics 2022-03-21 Sophie Marbach , Jeana Aojie Zheng , Miranda Holmes-Cerfon

Spider silk is biocompatible, biodegradable, and rivals some of the best synthetic materials in terms of strength and toughness. Despite extensive research, comprehensive experimental evidence of the formation and morphology of its internal…

Materials Science · Physics 2022-07-15 Dinidu Perera , Linxuan Li , Chloe Walsh , Qijue Wang , Hannes C. Schniepp

The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and…

Biological Physics · Physics 2009-05-08 Yan Chai , Reinhard Lipowsky , Stefan Klumpp

Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication. At constant applied force, theory predicts that the…

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