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Related papers: A Bell-Evans-Polanyi principle for molecular dynam…

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We address the problem of constructing accurate mathematical models of the dynamics of molecular systems projected on a collective variable. To this aim we introduce an algorithm optimizing the parameters of a standard or generalized…

Statistical Mechanics · Physics 2018-10-02 Andrea Pérez-Villa , Fabio Pietrucci

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…

Optimization and Control · Mathematics 2020-08-14 Amir Akbari , Bernhard O. Palsson

Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials. We investigate the…

Statistical Mechanics · Physics 2015-06-18 Hamid Teimouri , Anatoly B. Kolomeisky , Kareem Mehrabiani

General parameters are highly desirable in the natural sciences - e.g., chemical reaction conditions that enable high yields across a range of related transformations. This has a significant practical impact since those general parameters…

During a crossover via a switching mechanism from one 2-body potential to another as might be applied in modeling (chemical) reactions in the vicinity of bond formation, energy violations would occur due to finite step size which determines…

Computational Physics · Physics 2007-05-23 Christopher G Jesudason

Empirical force fields employed in molecular dynamics simulations of complex systems can be optimised to reproduce experimentally determined structural and thermodynamic properties. In contrast, experimental knowledge about the rates of…

Statistical Mechanics · Physics 2022-07-12 P. G. Bolhuis , Z. F. Brotzakis , B. G. Keller

Bounce-averaged theories provide a framework for simulating relatively slow processes, such as collisional transport and quasilinear diffusion, by averaging these processes over the fast periodic motions of a particle on a closed orbit.…

Plasma Physics · Physics 2025-07-02 I. E. Ochs

We study equations for the mechanical movement of chains of identical particles in the plane interacting with their nearest-neighbors by bond stretching and by van der Waals and Coulomb forces. We find collinear and circular equilibria as…

Dynamical Systems · Mathematics 2016-12-08 Carlos García-Azpeitia , Manuel Tejada-Wriedt

Local optimization presents a promising approach to expensive, high-dimensional black-box optimization by sidestepping the need to globally explore the search space. For objective functions whose gradient cannot be evaluated directly,…

Machine Learning · Computer Science 2023-01-18 Quan Nguyen , Kaiwen Wu , Jacob R. Gardner , Roman Garnett

We study the law of the minimum of a Brownian bridge, conditioned to take specific values at specific points, and the law of the location of the minimum. They are used to compare some non-adaptive optimisation algorithms for black-box…

Optimization and Control · Mathematics 2017-11-15 Aureli Alabert , Ricard Caballero

We discuss the structure of the equation of motion that governs nucleation processes at first order phase transitions. From the underlying microscopic dynamics of a nucleating system, we derive by means of a non-equilibrium projection…

Statistical Mechanics · Physics 2019-12-04 Anja Kuhnhold , Hugues Meyer , Graziano Amati , Philipp Pelagejcev , Tanja Schilling

The first goal of Vibration-Transit (V-T) theory was to construct a tractable approximate Hamiltonian from which the equilibrium thermodynamic properties of monatomic liquids can be calculated. The Hamiltonian for vibrations in an…

Soft Condensed Matter · Physics 2007-05-23 Giulia DeLorenzi-Venneri , Duane Wallace

To understand the behaviour of complex systems it is often necessary to use models that describe the dynamics of subnetworks. It has previously been established using projection methods that such subnetwork dynamics generically involves…

Molecular Networks · Quantitative Biology 2016-06-08 Katy J. Rubin , Peter Sollich

We study a system of reflected Brownian motions on the positive half-line in which each particle has a drift toward the origin determined by the local times at the origin of all the particles. If this local time drift is too strong, such…

Probability · Mathematics 2026-02-12 Graeme Baker , Ben Hambly , Philipp Jettkant

We describe collective-move Monte Carlo algorithms designed to approximate the overdamped dynamics of self-assembling nanoscale components equipped with strong, short-ranged and anisotropic interactions. Conventional Monte Carlo simulations…

Statistical Mechanics · Physics 2012-04-16 Stephen Whitelam

In this short note we sketch the statistical physics framework of the replica exchange technique when applied to molecular dynamics simulations. In particular, we draw attention to generalized move sets that allow a variety of optimizations…

Quantitative Methods · Quantitative Biology 2009-11-13 Walter Nadler , Ulrich H. E. Hansmann

Efficient algorithms for the calculation of minimum energy paths of magnetic transitions are implemented within the geodesic nudged elastic band (GNEB) approach. While an objective function is not available for GNEB and a traditional line…

Computational Physics · Physics 2020-11-30 Aleksei V. Ivanov , Damjan Dagbartsson , Julien Tranchida , Valery M. Uzdin , Hannes Jónsson

The rotating-wave approximation to light-matter interactions is widely used in the quantum electrodynamics Hamiltonian; however, its validity has long been a matter of debate. In this article, we explore the impact of the rotating-wave…

Quantum Physics · Physics 2024-03-04 Yi-Ting Chuang , Liang-Yan Hsu

The accurate determination of the lowest electron attachment ($EA$) and ionization ($IP$) energies for molecules embedded in molecular junctions is important for correctly estimating, \emph{e.g.}, the magnitude of the currents ($I$) or the…

Chemical Physics · Physics 2015-09-21 Ioan Baldea

We investigate the possibility of stochastic acceleration of background low-energy electrons by turbulent plasma waves. We consider the resonant interaction of the charged particles with all branches of the transverse plasma waves…

Astrophysics · Physics 2009-10-28 Julia M. Pryadko , Vahe Petrosian