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Gene regulatory networks (GRNs) represent the causal relationships between transcription factors (TFs) and target genes in single-cell RNA sequencing (scRNA-seq) data. Understanding these networks is crucial for uncovering disease…

Artificial Intelligence · Computer Science 2024-10-22 Tejumade Afonja , Ivaxi Sheth , Ruta Binkyte , Waqar Hanif , Thomas Ulas , Matthias Becker , Mario Fritz

Large Language Models (LLMs) such as GPT-4 and Llama3 have significantly impacted various fields by enabling high-quality synthetic data generation and reducing dependence on expensive human-generated datasets. Despite this, challenges…

Computation and Language · Computer Science 2025-11-18 Yue Huang , Siyuan Wu , Chujie Gao , Dongping Chen , Qihui Zhang , Yao Wan , Tianyi Zhou , Jianfeng Gao , Chaowei Xiao , Lichao Sun , Xiangliang Zhang

This paper is to introduce an asynchronous and local learning framework for neural networks, named Modular Learning Framework (MOLE). This framework modularizes neural networks by layers, defines the training objective via mutual…

Machine Learning · Computer Science 2026-05-28 Tianchao Li , Yulong Pei

Synthetic oversampling of minority examples using SMOTE and its variants is a leading strategy for addressing imbalanced classification problems. Despite the success of this approach in practice, its theoretical foundations remain…

Machine Learning · Statistics 2025-10-24 Touqeer Ahmad , Mohammadreza M. Kalan , François Portier , Gilles Stupfler

In standard generative deep learning models, such as autoencoders or GANs, the size of the parameter set is proportional to the complexity of the generated data distribution. A significant challenge is to deploy resource-hungry deep…

Machine Learning · Computer Science 2021-10-29 Shreshth Tuli , Shikhar Tuli , Giuliano Casale , Nicholas R. Jennings

Despite significant recent progress in the area of Brain-Computer Interface (BCI), there are numerous shortcomings associated with collecting Electroencephalography (EEG) signals in real-world environments. These include, but are not…

Quantitative Methods · Quantitative Biology 2019-10-14 Nik Khadijah Nik Aznan , Amir Atapour-Abarghouei , Stephen Bonner , Jason Connolly , Noura Al Moubayed , Toby Breckon

Recent deep networks are capable of memorizing the entire data even when the labels are completely random. To overcome the overfitting on corrupted labels, we propose a novel technique of learning another neural network, called MentorNet,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Lu Jiang , Zhengyuan Zhou , Thomas Leung , Li-Jia Li , Li Fei-Fei

Representation learning and unsupervised learning are two central topics of machine learning and signal processing. Deep learning is one of the most effective unsupervised representation learning approach. The main contributions of this…

Machine Learning · Computer Science 2014-01-06 Xiao-Lei Zhang , Ji Wu

SVEMnet is an R package for fitting Self-Validated Ensemble Models (SVEM) with elastic-net base learners and performing multi-response optimization in small-sample mixture-process design-of-experiments (DOE) studies with numeric,…

Computation · Statistics 2026-03-10 Andrew T. Karl

Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

SCYNet (SUSY Calculating Yield Net) is a tool for testing supersymmetric models against LHC data. It uses neural network regression for a fast evaluation of the profile likelihood ratio. Two neural network approaches have been developed:…

This paper discusses the latest generation of the MONARC (MOdels of Networked Analysis at Regional Centers) simulation framework, as a design and modelling tool for large scale distributed systems applied to HEP experiments. A…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-06-28 Ciprian Dobre , Corina Stratan

An emerging branch of control theory specialises in certificate learning, concerning the specification of a desired (possibly complex) system behaviour for an autonomous or control model, which is then analytically verified by means of a…

Systems and Control · Electrical Eng. & Systems 2024-10-29 Alec Edwards , Andrea Peruffo , Alessandro Abate

Training data mixtures greatly impact the generalization performance of large language models. Existing domain reweighting methods often rely on costly weight computations and require retraining when new data is introduced. To this end, we…

Machine Learning · Computer Science 2025-06-02 Wanyun Xie , Francesco Tonin , Volkan Cevher

Recent advances in learning for control allow to synthesize vehicle controllers from learned system dynamics and maintain robust stability guarantees. However, no approach is well-suited for training linear time-invariant (LTI) controllers…

Systems and Control · Electrical Eng. & Systems 2022-05-11 Marc-Antoine Beaudoin , Benoit Boulet

The behavior of Internet applications is shaped by congestion dynamics at bottleneck links, yet data capturing application behavior across diverse bottleneck regimes remains scarce. Bridging this gap requires a data-generation substrate…

Networking and Internet Architecture · Computer Science 2026-02-23 Jaber Daneshamooz , Satyandra Guthula , Jessica Nguyen , William Chen , Sanjay Chandrasekaran , Ankit Gupta , Arpit Gupta , Walter Willinger

Programming by example is the problem of synthesizing a program from a small set of input / output pairs. Recent works applying machine learning methods to this task show promise, but are typically reliant on generating synthetic examples…

Machine Learning · Computer Science 2019-11-11 Judith Clymo , Haik Manukian , Nathanaël Fijalkow , Adrià Gascón , Brooks Paige

A major challenge in applying machine learning to automated theorem proving is the scarcity of training data, which is a key ingredient in training successful deep learning models. To tackle this problem, we propose an approach that relies…

Artificial Intelligence · Computer Science 2021-04-08 Vlad Firoiu , Eser Aygun , Ankit Anand , Zafarali Ahmed , Xavier Glorot , Laurent Orseau , Lei Zhang , Doina Precup , Shibl Mourad

Artificial neural networks that simulate human achieves great successes. From the perspective of simulating human memory method, we propose a stepped sampler based on the "repeated input". We repeatedly inputted data to the LSTM model…

Machine Learning · Computer Science 2021-08-31 Dengshan Li , Rujing Wang , Chengjun Xie

Biological systems can be studied at multiple levels of information, including gene, protein, RNA and different interaction networks levels. The goal of this work is to explore how the fusion of systems' level information with temporal…

Genomics · Quantitative Biology 2023-02-09 Jan Kralj , Blaž Škrlj , Živa Ramšak , Nada Lavrač , Kristina Gruden