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Molecular transport in living systems regulates numerous processes underlying biological function. Although many cellular components exhibit anomalous diffusion, only recently has the subdiffusive motion been associated with nonergodic…

Spatiotemporal disorder has been recently associated to the occurrence of anomalous nonergodic diffusion of molecular components in biological systems, but the underlying microscopic mechanism is still unclear. We introduce a model in which…

Statistical Mechanics · Physics 2017-03-15 C. Charalambous , G. Muñoz-Gil , A. Celi , M. F. Garcia-Parajo , M. Lewenstein , C. Manzo , M. A. García-March

One of the most challenging problems in microbiology is to understand how a small fraction of microbes that resists killing by antibiotics can emerge in a population of genetically identical cells, the phenomenon known as persistence or…

Subcellular Processes · Quantitative Biology 2015-06-17 Andrea Rocco , Andrzej M. Kierzek , Johnjoe McFadden

The choice of boundary condition makes an essential difference in the solution structure of diffusion equations. The Dirichlet and Neumann boundary conditions and their combination have been the most used, but their legitimacy has been…

Analysis of PDEs · Mathematics 2023-08-02 Jaywan Chung , Seungmin Kang , Ho-Youn Kim , Yong-Jung Kim

We study analytically how noninteracting weakly active particles, for which passive Brownian diffusion cannot be neglected and activity can be treated perturbatively, distribute and behave near boundaries in various geometries. In…

Soft Condensed Matter · Physics 2021-05-05 Michael Wang

We investigate a system of two polarized molecules in a layered trap. The molecules reside in adjacent layers and interact purely via the dipole-dipole interaction. We determine the properties of the ground state of the system as a function…

Atomic and Molecular Clusters · Physics 2011-06-01 D. V. Fedorov , J. R. Armstrong , N. T. Zinner , A. S. Jensen

Consider a finite system of diffusing particles coupled through a reactive boundary. Each particle is reflected, but may react with the boundary according to a killing mechanism which depends on the current reactivity of the boundary and…

Probability · Mathematics 2026-05-20 Eliana Fausti , Andreas Sojmark

The ergodicity breaking parameter is a measure for the heterogeneity among different trajectories of one ensemble. In this report this parameter is calculated for fractional Brownian motion with a random change of time scale, often called…

Data Analysis, Statistics and Probability · Physics 2015-06-17 Felix Thiel , Igor M. Sokolov

Diffusion in cell membranes is not just simple two-dimensional Brownian motion, but typically depends on the timescale of the observation. The physical origins of this anomalous sub-diffusion are unresolved, and model systems capable of…

Biological Physics · Physics 2017-10-25 H. L. E. Coker , M. R. Cheetham , D. R. Kattnig , Y. J. Wang , S. Garcia-Manyes , M. I. Wallace

We consider weakly interacting diffusions on time varying random graphs. The system consists of a large number of nodes in which the state of each node is governed by a diffusion process that is influenced by the neighboring nodes. The…

Probability · Mathematics 2017-02-16 Shankar Bhamidi , Amarjit Budhiraja , Ruoyu Wu

A popular approach to modeling bimolecular reactions between diffusing molecules is through the use of reactive boundary conditions. One common model is the Smoluchowski partial absorption condition, which uses a Robin boundary condition in…

Biological Physics · Physics 2015-11-17 S. Jonathan Chapman , Radek Erban , Samuel A. Isaacson

In a general class of one dimensional random differential equation the convergence of the distribution function of the solution to stationary state distribution is studied. In particular it is proved the boundedness respectively the…

Probability · Mathematics 2010-07-07 Gyorgy Steinbrecher , Xavier Garbet , Boris Weyssow

The effects of a boundary on reaction systems are examined in the framework of the general single-species reaction/coalescence process. The boundary naturally represents the reactants' container, but is applicable to exciton dynamics in a…

Statistical Mechanics · Physics 2009-10-31 M. J. E. Richardson , Y. Kafri

Several problems, issued from physics, biology or the medical science, lead to parabolic equations set in two sub-domains separated by a membrane with selective permeability to specific molecules. The corresponding boundary conditions,…

Analysis of PDEs · Mathematics 2022-06-27 Giorgia Ciavolella , Benoît Perthame

We explore the mechanism responsible for the ergodicity breaking in systems with long-range forces. In thermodynamic limit such systems do not evolve to the Boltzmann-Gibbs equilibrium, but become trapped in an out-of-equilibrium…

Statistical Mechanics · Physics 2013-05-14 Fernanda P. da C. Benetti , Tarcísio N. Teles , Renato Pakter , Yan Levin

Nonlinear diffusion is studied in the presence of multiplicative noise. The nonlinearity can be viewed as a ``wall'' limiting the motion of the diffusing field. A dynamic phase transition occurs when the system ``unbinds'' from the wall.…

Statistical Mechanics · Physics 2009-10-30 M. A. Muñoz , T. Hwa

The activity of biological cells is primarily based on chemical reactions and typically modeled as a reaction-diffusion system. Cells are, however, highly crowded with macromolecules, including a variety of molecular machines such as…

Biological Physics · Physics 2018-11-02 Yuichi Togashi

We analyze an inhomogeneous system of coupled reaction-diffusion equations representing the dynamics of gene expression during differentiation of nerve cells. The outcome of this developmental phase is the formation of distinct functional…

Analysis of PDEs · Mathematics 2014-08-28 Benoit Perthame , Cristobal Quiñinao , Jonathan Touboul

The dynamics of particles interacting by key-lock binding of attached biomolecules are studied theoretically. Examples of such systems include DNA-functionalized colloids as well as nanoparticles grafted with antibodies to cell membrane…

Soft Condensed Matter · Physics 2007-05-23 Nicholas A. Licata , Alexei V. Tkachenko

The use of fully or partially absorbing boundary conditions for diffusion-based problems has become paradigmatic in physical chemistry and biochemistry to describe reactions occurring in solutions or in living media. However, as chemical…

Statistical Mechanics · Physics 2022-12-13 Francesco Piazza