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Motivated by high-throughput single-cell cytometry data with applications to vaccine development and immunological research, we consider statistical clustering in large-scale data that contain multiple rare clusters. We propose a new…

Methodology · Statistics 2016-06-30 Lin Lin , Jia Li

Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of…

Chemical Physics · Physics 2015-06-17 Frank Noe , Hao Wu , Jan-Hendrik Prinz , Nuria Plattner

The most famous error-decoding algorithm for convolutional codes is the Viterbi algorithm. In this paper, we present a new reduced complexity version of this algorithm which can be applied to a class of binary convolutional codes with…

Information Theory · Computer Science 2024-07-26 Zita Abreu , Julia Lieb , Michael Schaller

Hidden Markov Models (HMM) model a sequence of observations that are dependent on a hidden (or latent) state that follow a Markov chain. These models are widely used in diverse fields including ecology, speech recognition, and…

Optimization and Control · Mathematics 2024-09-05 Sidonie Foulon , Thérèse Truong , Anne-Louise Leutenegger , Hervé Perdry

We present a lightweight approach to sequence classification using Ensemble Methods for Hidden Markov Models (HMMs). HMMs offer significant advantages in scenarios with imbalanced or smaller datasets due to their simplicity,…

Machine Learning · Computer Science 2024-09-13 Maxime Kawawa-Beaudan , Srijan Sood , Soham Palande , Ganapathy Mani , Tucker Balch , Manuela Veloso

A goal of clinical researchers is to understand the progression of a disease through a set of biomarkers. Researchers often conduct observational studies, where they collect numerous samples from selected subjects throughout multiple years.…

Human-Computer Interaction · Computer Science 2020-07-27 Bum Chul Kwon

We present a novel algorithm for learning the parameters of hidden Markov models (HMMs) in a geometric setting where the observations take values in Riemannian manifolds. In particular, we elevate a recent second-order method of moments…

Machine Learning · Computer Science 2023-02-16 Berlin Chen , Cyrus Mostajeran , Salem Said

As the use of Internet of Things (IoT) devices for monitoring purposes becomes ubiquitous, the efficiency of sensor communication is a major issue for the modern Internet. Channel coding is less efficient for extremely short packets, and…

Networking and Internet Architecture · Computer Science 2021-01-21 Siddharth Chandak , Federico Chiariotti , Petar Popovski

We describe libhmm, a C++20 library for Hidden Markov Model parameter estimation, sequence decoding, and model selection. libhmm addresses two gaps in existing software: the absence of a well-maintained, zero-dependency C++ HMM library…

Mathematical Software · Computer Science 2026-05-29 Gary Wolfman

Experiments, in particular on biological systems, typically probe lower-dimensional observables which are projections of high-dimensional dynamics. In order to infer consistent models capturing the relevant dynamics of the system, it is…

Statistical Mechanics · Physics 2025-11-18 Xizhu Zhao , Dmitrii E. Makarov , Aljaž Godec

A Hidden Markov Model (HMM) is a common statistical model which is widely used for analysis of biological sequence data and other sequential phenomena. In the present paper we show how HMMs can be extended with side-constraints and present…

Artificial Intelligence · Computer Science 2010-08-02 Henning Christiansen , Christian Theil Have , Ole Torp Lassen , Matthieu Petit

This paper describes a parallel implementation of Viterbi decoding algorithm. Viterbi decoder is widely used in many state-of-the-art wireless systems. The proposed solution optimizes both throughput and memory usage by applying…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-19 Alireza Mohammadidoost , Matin Hashemi

The Hidden Markov Model (HMM) is a widely-used statistical model for handling sequential data. However, the presence of missing observations in real-world datasets often complicates the application of the model. The EM algorithm and Gibbs…

Machine Learning · Statistics 2026-01-06 Dongrong Li , Tianwei Yu , Xiaodan Fan

We address the problem of analyzing sets of noisy time-varying signals that all report on the same process but confound straightforward analyses due to complex inter-signal heterogeneities and measurement artifacts. In particular we…

Symbol detection plays an important role in the implementation of digital receivers. In this work, we propose ViterbiNet, which is a data-driven symbol detector that does not require channel state information (CSI). ViterbiNet is obtained…

Machine Learning · Computer Science 2020-10-01 Nir Shlezinger , Nariman Farsad , Yonina C. Eldar , Andrea J. Goldsmith

We aim to model unknown file processing. As the content of log files often evolves over time, we established a dynamic statistical model which learns and adapts processing and parsing rules. First, we limit the amount of unstructured text…

Machine Learning · Computer Science 2020-01-07 Nadine Kuhnert , Andreas Maier

Hidden Markov models (HMM) have been widely used by scientists to model stochastic systems: the underlying process is a discrete Markov chain and the observations are noisy realizations of the underlying process. Determining the number of…

Statistics Theory · Mathematics 2024-07-18 Yang Chen , Cheng-Der Fuh , Chu-Lan Michael Kao

To analyze whole-genome genetic data inherited in families, the likelihood is typically obtained from a Hidden Markov Model (HMM) having a state space of 2^n hidden states where n is the number of meioses or edges in the pedigree. There…

Probability · Mathematics 2013-10-07 Bonnie Kirkpatrick , Kay Kirkpatrick

Modeling of conservative systems with neural networks is an area of active research. A popular approach is to use Hamiltonian neural networks (HNNs) which rely on the assumptions that a conservative system is described with Hamilton's…

Artificial Intelligence · Computer Science 2024-07-18 Katsiaryna Haitsiukevich , Alexander Ilin

As a relatively new field, network neuroscience has tended to focus on aggregate behaviours of the brain averaged over many successive experiments or over long recordings in order to construct robust brain models. These models are limited…

Neurons and Cognition · Quantitative Biology 2022-05-19 James Wilsenach , Katie Warnaby , Charlotte M. Deane , Gesine Reinert