Tissues and Organs
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of this study was to assess the neuroprotective effect and the…
A model is proposed to minimize the total volume of the main distribution networks of fluids in relation to the organ form. The minimization analysis shows that the overall exterior form of distribution networks is a modified ellipsoid, a…
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered…
The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min. After the end of ischemia and at…
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective…
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration…
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors…
Continuum strain energy functions are developed for soft biological tissues that possess long fibrillar components. The treatment is based on the model of an elastica, which is our fine scale model, and is homogenized in a simple fashion to…
We propose a mathematical model allowing for the alternating pulse and surge pattern of GnRH (Gonadotropin Releasing Hormone) secretion. The model is based on the coupling between two systems running on different time scales. The faster…
It is now evident that the commonly accepted strategy for treatment of HIV/AIDS by highly active antiretroviral therapy (HAART) will not lead to eradication of HIV in a reasonable time. This is straightforward from the typical exponential…
Employing a novel two-dimensional computational model we have simulated the feedback between angiogenesis and tumor growth dynamics. Analyzing vessel formation and elongation towards the concentration gradient of the tumor-derived…
Fetal heart rate (FHR) monitoring, before and during labor, is a very important medical practice in the detection of fetuses in danger. We clustered FHR tracings by compression in order to identify abnormal ones. We use a recently…
Primary lymphoid follicles in secondary lymphoid tissue of mammals are the backbone for the formation of follicular dendritic cell networks. These are important for germinal center reactions. In the context of organogenesis molecular…
Muscles crossing a joint usually outnumber its degrees of freedom, which renders the motor system underdetermined. Typically, optimization laws are postulated to cope with this redundancy. A natural question then arises whether all muscular…
Assuming that there is feedback between an expanding cancer system and its organ-typical microenvironment, we argue here that such local tumor growth is guided by co-existence rather than competition with the surrounding tissue. We then…
Knowledge regarding the kinetics of metastatic tumor formation, as related to the growth of the primary tumor, represents a fundamental issue in cancer biology. Using an in vivo mammalian model, we show here that one can obtain useful…
We describe an asymptotic approach to gated ionic models of single-cell cardiac excitability. It has a form essentially different from the Tikhonov fast-slow form assumed in standard asymptotic reductions of excitable systems. This is of…
We investigate, both experimentally and theoretically, the bifurcation to alternans in heart tissue. Previously, this phenomenon has been modeled either as a smooth or as border-collision period-doubling bifurcation. Using a new…
One of the mechanisms that ensure cancer robustness is tumor heterogeneity, and its effects on tumor cells dynamics have to be taken into account when studying cancer progression. There is no unifying theoretical framework in mathematical…
FT-Raman spectroscopy was employed to study (in-vitro) non-altered human colorectal tissues aiming evaluate their spectral differences. The samples were collected from 39 patients, adding 144 spectra. The results enable one estabilish 3…