Tissues and Organs
We demonstrate the robust scale-invariance in the probability density function (PDF) of detrended healthy human heart rate increments, which is preserved not only in a quiescent condition, but also in a dynamic state where the mean level of…
One's present repertoire of antibodies encodes the history of one's past immunological experience. Can the present autoantibody repertoire be consulted to predict resistance or susceptibility to the future development of an autoimmune…
A theoretical analysis of the mechanisms underlying the dynamics of gallbladder and heart pulsation could clarify the question regarding the classification as chaotic of the associated behaviour, eventually related to a normal and healthy…
We propose a travelling-wave perturbation method to control the spatiotemporal dynamics in a cardiac model. It is numerically demonstrated that the method can successfully suppress the wave instability (alternans in action potential…
The prediction and prevention of traumatic brain injury, spinal injury and general musculo-skeletal injury is a very important aspect of preventive medical science. Recently, in a series of papers, I have proposed a new coupled loading-rate…
Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other tissues and metastasis. This paper presents a qualitative…
FT-Raman Spectroscopy was applied to identify biochemical alterations existing between inflammatory fibrous hyperplasia (IFH) and normal tissues of buccal mucosa. One important implication of this study is related to the cancer lesion…
A model of the regular arrangement of leaves on a plant stem (phyllotactic patterns) is proposed, based on a new plant pattern algorithm. Tripartite patterning is proposed to occur by the interaction of two signaling pathways. Each pathway…
Background: An increased QT/RR slope is hypothesized to be predictive of sudden cardiac death after myocardial infarction. Previous studies have shown that beta-adrenergic stimulation increases QT/RR slope, but the effects of…
A model of pattern formation in living systems is presented. The pattern is achieved by the sequential interaction of two signaling pathways. The coupling of the pattern to the (thick) epithelial sheet changes is given, when the Gauss…
Prediction and prevention of musculo-skeletal injuries is an important aspect of preventive health science. Using as an example a human knee joint, this paper proposes a new coupled-loading-rate hypothesis, which states that a generic cause…
We tested the hypothesis that the fetal-placental relationship scales allometrically and identified modifying factors. Among women delivering after 34 weeks but prior to 43 weeks gestation, 24,601 participants in the Collaborative Perinatal…
This paper is the instructions for the proceeding of the International Symposium on Crop. Sugar beet crop models have rarely taken into account the morphogenetic process generating plant architecture despite the fact that plant…
Glucose homeostasis is controlled by the islets of Langerhans which are equipped with alpha-cells increasing the blood glucose level, beta-cells decreasing it, and delta-cells the precise role of which still needs identifying. Although…
We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration…
Thoracocardiography approach pretends to non-invasively monitor stroke volume by inductive plethysmographic recording of ventricular volume curves by a transducer placed on the chest. The purpose of this study was to investigate the…
Self-regulation of living tissue as an example of self-organization phenomena in active fractal systems of biological, ecological, and social nature is under consideration. The characteristic feature of these systems is the absence of any…
The prediction and prevention of traumatic brain injury is a very important aspect of preventive medical science. This paper proposes a new coupled loading-rate hypothesis for the traumatic brain injury (TBI), which states that the main…
Environmental and genetic mutations can transform the cells in a co-operating healthy tissue into an ecosystem of individualistic tumour cells that compete for space and resources. Various selection forces are responsible for driving the…
Tumour progression has been described as a sequence of traits or phenotypes that cells have to acquire if the neoplasm is to become an invasive and malignant cancer. Although the genetic mutations that lead to these phenotypes are random,…