Tissues and Organs
The dynamic patterning of the plant hormone auxin and its efflux facilitator the PIN protein are the key regulator for the spatial and temporal organization of plant development. In particular auxin induces the polar localization of its own…
The effects of the X-rays carried out in a photon beam produced by a medical linear particle accelerator on the progression of the cell cycle in normal cells Vero were evaluated by flow cytometric mean. The evaluation of the consequences of…
The biological effect of one single radiation dose on a living tissue has been described by several radiobiological models. However, the fractionated radiotherapy requires to account for a new magnitude: time. In this paper we explore the…
Turing models have been proposed to explain the emergence of digits during limb development. However, so far the molecular components that would give rise to Turing patterns are elusive. We have recently shown that a particular type of…
We present in vitro and in vivo studies of yttrium-90 (90Y)-labelled human serum albumin magnetic microspheres (HSAMMS) as multifunctional agent for bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS were produced using a modified…
Zinc uptake in roots is believed to be mediated by ZIP (ZRT-, IRT-like Proteins) transporters. Once inside the symplast, zinc is transported to the pericycle, where it exits by means of HMA (Heavy Metal ATPase) transporters. The combination…
We derive the analytical solutions to the second order generalised gravi-proprioceptive equation given in our recent paper [Bastien et al. 2012]. These equations show how plants adjust to the surrounding gravitation field and highlight the…
Organogenesis is a tightly regulated process that has been studied experimentally for decades. We are developing mechanistic models for the morphogenesis of limbs, lungs, and kidneys with a view to integrate available knowledge and to…
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature. Lung branching morphogenesis is strongly stereotyped and involves the…
Hodgkin lymphoma is an unusual type of lymphoma, arising from malignant B-cells. Morphological and immunohistochemical features of malignant cells and their distribution differ from other cancer types. Based on systematic tissue image…
We investigate the canonical Scheidegger Model of river network morphology for the case of convergent and divergent underlying topography, by embedding it on a cone. We find two distinct phases corresponding to few, long basins and many,…
The theoretical case is considered where the total amount of plasma protein is conserved, but the drug is eliminated after its single application. After a single drug application at time t = 0, the total drug concentration is measured at…
There has been certain criticism raised by A. Rescigno [2,8,9,12-15] against the standard formulation of pharmacokinetics. In 2011 it has been suggested that inconsistencies in pharmacokinetics should be eliminated after deriving…
A mathematical model of a drug transport after rapid injection is given. It takes into account three processes: - drug plasma protein binding in central compartment - transport processes between the central compartment and the peripheral…
Sound is detected and converted into electrical signals within the ear. The cochlea not only acts as a passive detector of sound, however, but can also produce tones itself. These otoacoustic emissions are a striking manifestation of the…
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is…
Fifty cases of breast carcinoma were investigated for Nm23, LPA1, Ki67 and p53 antigen expression, using immunohistochemical techniques. Correlation between markers was studied. Nm23 showed an inverse correlation with LPA1 and Ki67, and…
An intriguing unanswered question about the evolution of bilateral animals with internal skeletons is how an internal skeleton evolved in the first place. Computational modeling of the development of bilateral symmetric organisms suggests…
Background: Cadmium chloride is an environmental toxic that affects the male reproductive system. This study was directed 1) to evaluate whether long-term oral exposures to low doses of Cd in rats causes morphological changes, 2) the…
A computational theory and model of the ontogeny and development of bilateral symmetry in multicellular organisms is presented. Understanding the origin and evolution of bilateral organisms requires an understanding of how bilateral…