Biological Physics
Recent advances in microphysiological systems have underscored the need for novel sensing and monitoring systems specifically designed for three-dimensional (3D) cell culture. In this article, an original architecture of a cell-culture…
The magnetic sensing mechanism proposed to exist in avian eyes functions as a compass that detects the geomagnetic inclination aiding their migration. This mechanism is modeled by a quantum spin model known as the radical pair (RP) model.…
Surface-adhesion and stiffness of underlying substrates mediate geometry, mechanics and self-organization of bacterial colonies. Recent studies have qualitatively indicted that stiffness may impact bacterial attachment, yet the variation of…
The transition of an epithelial layer from a stationary, quiescent state to a highly migratory, dynamic state is required for wound healing, development, and regeneration. This transition, known as the unjamming transition (UJT), is…
Bacteria aggregate through various intercellular interactions to build biofilms, but the effect of environmental changes thereupon remains largely unexplored. Here, by using an experimental device that overcomes past difficulties, we…
Molecular sorting in biological membranes is essential for proper cellular function. It also plays a crucial role in the budding of enveloped viruses from host cells. We recently proposed that this process is driven by phase separation,…
Ferroptosis, a regulated form of cell death driven by oxidative stress and lipid peroxidation, has emerged as a pivotal research focus with implications across various cellular contexts. In this study, we employed a multifaceted approach,…
Development of scoring functions (SFs) used to predict protein-ligand binding energies requires high-quality 3D structures and binding assay data for training and testing their parameters. In this work, we show that one of the widely-used…
Accurate gradient sensing is crucial for efficient chemotaxis in noisy environments, but the relationship between cell shape deformations and sensing accuracy is not well understood. Using a theoretical framework based on maximum likelihood…
Diverse organisms exploit the geomagnetic field (GMF) for migration. Migrating birds employ an intrinsically quantum mechanical mechanism for detecting the geomagnetic field: absorption of a blue photon generates a radical pair whose two…
Biophysical modeling of diffusion MRI (dMRI) offers the exciting potential of bridging the gap between the macroscopic MRI resolution and microscopic cellular features, effectively turning the MRI scanner into a noninvasive in vivo…
Ion channels selectively transport ions, yet the underlying mechanisms remain elusive. We propose a physical model based on the Driven Damped Harmonic Oscillator (DDHO), where self-organizing turbulent structures in the ionic flow generate…
The social organization of microorganisms has long been a fascinating and challenging subject in both biology and sociology. In these organisms, the role of the individual is far less dominant than that of the community, which functions as…
Biological processes, functions, and properties are intricately linked to the ensemble of protein conformations, rather than being solely determined by a single stable conformation. In this study, we have developed P2DFlow, a generative…
The interaction mechanism between a single microscopic object like a cell, a particle, a molecule, or an atom and its interacting electromagnetic field is fundamental in single-object manipulation such as optical trap and magnetic trap.…
Life science research has largely benefited from the use of nanoparticles (NPs), yet fundamental issues such as colloidal stability and control over NP size and shape affect NP properties and functions in biomedical applications. Here we…
Inspired by the natural defence strategies of insect wings and plant leaves, nanostructured surfaces have emerged as a promising tool in various fields, including engineering, biomedical sciences, and materials science to combat bacterial…
Accurately modeling bending energy in morphogenetic simulations is crucial, especially when dealing with anisotropic meshes where remeshing is infeasible due to the biologically meaningful entities of vertex positions (e.g., cells). This…
Overcoming the strong chlorophyll background poses a significant challenge for measuring and optimizing plant growth. This research investigates the novel application of specialized quantum light emitters introduced into intact leaves of…
In multidimensional NMR spectroscopy, practical resolution is defined as the ability to distinguish and accurately determine signal positions against a background of overlapping peaks, thermal noise, and spectral artifacts. In the pursuit…