Biological Physics
Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal transduction, cellular homeostasis, and organismal…
Understanding the molecular mechanism by which denaturants modulate protein structure remains a central challenge in protein biophysics. In this work, molecular dynamics simulations were employed to investigate the effects of urea on the…
Multi-nucleated cells exist in all domains of life, ranging from animals, plants and fungi to single-celled organisms such as the slime mold Physarum polycephalum. The large cell size, in the case of Physarum reaching centimeters and more,…
We study the effects of weak magnetic fields (around 2 mT) on the growth of Staphylococcus aureus (S. aureus) in the presence of a few sweeteners (monosaccharides, disaccharides, sugar alcohols, and consumer-grade sweeteners). Bacterial…
Triplet formation and its regulation have always been of central interest in understanding the photophysical behavior of living systems. In organic systems, excessive triplet formation poses significant challenges, as it can promote…
Glassy carbon (GC) microelectrodes are increasingly being used for voltametric detection of electroactive neurotransmitters such as dopamine and serotonin. However, non-electroactive molecules including lactate, glutamate, and…
This e-letter re-evaluates the epidemiological impact of nationwide mass antigen testing in Slovakia. While initial reports \cite{Pavelka} proposed a causal link between these campaigns and declining viral prevalence, granular re-analysis…
Biological cells are able to adapt their behaviour in response to environmental cues. Durotaxis is a phenomenon in which cells adjust their migration depending on the mechanical properties of a surrounding substrate. Although durotaxis has…
A major unresolved question in Neuroscience is: What is the origin of the observed scale-invariant correlations in neural activity? Many researchers support the ``criticality hypothesis,'' which proposes that the brain operates near…
Contradictory experimental reports on the relationship between efficiency and stimulation frequency have hindered mechanistic understanding in converting neural activity into mechanical work during muscle contraction. To resolve this issue,…
Cells control their size to cope with noise during growth and division. Eukaryotic cells exhibiting "sizer" control (targeting a specific size before dividing) may rely on molecular concentration thresholds, but simple implementations of…
We investigate delay-induced collective dynamics in a two-layer multiplex FitzHugh Nagumo network with nonlocal intra layer coupling and delayed inter layer interactions. While delay effects are often treated as secondary, we show that…
In this work, we characterized the material properties of an animal model of the rotator cuff tendon using full volume datasets of both its intact and injured states by capturing internal strain behavior throughout the tendon. Our…
Neuromechanics aims to understand the link between an animal's neural activity and its physical behaviors. Recent advances in experimental and machine learning techniques enable simultaneous recordings of neural and locomotion dynamics over…
In proliferating cell populations, adaptive changes to biochemical reactions can change a cell's division time, which in turn can change the population size. However, biochemical reactions are subject to noise, and therefore the conditions…
Peptide nanofibrils (PNFs) and peptide amphiphiles (PAs) are promising tools for enhancing viral transduction and gene transfer. However, quantitative insight into how their supramolecular architecture governs virion-cell interactions is…
The burst approximation is a widely used technique to simplify stochastic gene expression models. However, the dynamics and analytical properties of the protein number distribution in gene expression models under the burst approximation are…
Lumens are cavities enclosed by polarized cells that are essential for organ function, from nutrient transport in the gut to gas exchange in the lungs. Defects in lumen formation are associated with severe diseases, including polycystic…
Optical imaging technologies are central to discovery in the life and physical sciences, yet their impact depends on how readily they can be built, adapted, and sustained across laboratories. Digital fabrication, including desktop 3D…
The SARS-CoV-2 RNA pseudoknot is a promising target for antiviral intervention, as it regulates the efficiency of $-$1 programmed ribosomal frameshifting ($-$1 PRF), a mechanism that is essential for viral protein synthesis. The pseudoknot…