DNA monolayers with inherent chirality play a pivotal role across various domains, including biosensors, DNA chips, and bioelectronics. Nonetheless, conventional DNA chiral monolayers, typically constructed from single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA), often lack structural orderliness and design flexibility at the interface. Structural DNA nanotechnology emerges as a promising solution to tackle these challenges. In this study, we present a strategy for crafting highly adaptable twisted DNA origami-based chiral monolayers. These structures exhibit distinct interfacial assembly characteristics and effectively mitigate the structural disorder of dsDNA monolayers, which is constrained by a limited persistence length of ~50 nm of dsDNA. We highlight the spin-filtering capabilities of four representative DNA origami-based chiral monolayers, demonstrating a maximal one-order-of-magnitude increase in spin-filtering efficiency per unit area compared to conventional dsDNA chiral monolayers. Intriguingly, our findings reveal that the higher-order, tertiary, chiral structure of twisted DNA origami further enhances the spin-filtering efficiency. This work paves the way for the rational design of DNA chiral monolayers.
@article{arxiv.2310.09475,
title = {Twisted DNA origami-based chiral monolayers for spin filtering},
author = {Haozhi Wang and Fangfei Yin and Linyun Li and Mingqiang Li and Zheng Fang and Chenyun Sun and Bochen Li and Jiye Shi and Jiang Li and Lihua Wang and Shiping Song and Xiaolei Zuo and Xiaoguo Liu and Chunhai Fan},
journal= {arXiv preprint arXiv:2310.09475},
year = {2023}
}