Synchronized Pivots
Biomolecules
2020-03-30 v1 Molecular Networks
Abstract
Thermodynamic profiles, based on bioinformatic hydropathicity scales and membrane-fitted sliding windows, exhibit accurately level sets of hydrophobic peaks or valleys in the constant fragment Fc of monoclonal antibodies. These sets provide a roadmap for selected short regions where a few directed amino acid mutations could produce either accelerated antibody kinetics or increased stability. These profiles may reveal dramatic differences in antibody activity
Cite
@article{arxiv.2003.12441,
title = {Synchronized Pivots},
author = {J. C. Phillips},
journal= {arXiv preprint arXiv:2003.12441},
year = {2020}
}
Comments
15 pages, 5 figures