Stress Clamp Experiments on Multicellular Tumor Spheroids
Biological Physics
2017-08-23 v1 Medical Physics
Tissues and Organs
Abstract
The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the mechanics of this interaction. Using a novel experimental procedure, we study quantitatively the effect of an applied mechanical stress on the long-term growth of a spheroid cell aggregate. We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid. We compare the results to a simple numerical model developed to describe the role of mechanics in cancer progression.
Keywords
Cite
@article{arxiv.1111.5814,
title = {Stress Clamp Experiments on Multicellular Tumor Spheroids},
author = {Fabien Montel and Morgan Delarue and Jens Elgeti and Laurent Malaquin and Markus Basan and Thomas Risler and Bernard Cabane and Danijela Vignjevic and Jacques Prost and Giovanni Cappello and Jean-François Joanny},
journal= {arXiv preprint arXiv:1111.5814},
year = {2017}
}
Comments
5 pages, 4 figures