Selection, recombination, and the ancestral initiation graph
Populations and Evolution
2021-10-18 v3 Probability
Abstract
Recently, the selection-recombination equation with a single selected site and an arbitrary number of neutral sites was solved by means of the ancestral selection-recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection-recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.
Cite
@article{arxiv.2101.10080,
title = {Selection, recombination, and the ancestral initiation graph},
author = {Frederic Alberti and Carolin Herrmann and Ellen Baake},
journal= {arXiv preprint arXiv:2101.10080},
year = {2021}
}