An approximate sampling formula under genetic hitchhiking
Abstract
For a genetic locus carrying a strongly beneficial allele which has just fixed in a large population, we study the ancestry at a linked neutral locus. During this ``selective sweep'' the linkage between the two loci is broken up by recombination and the ancestry at the neutral locus is modeled by a structured coalescent in a random background. For large selection coefficients and under an appropriate scaling of the recombination rate, we derive a sampling formula with an order of accuracy of in probability. In particular we see that, with this order of accuracy, in a sample of fixed size there are at most two nonsingleton families of individuals which are identical by descent at the neutral locus from the beginning of the sweep. This refines a formula going back to the work of Maynard Smith and Haigh, and complements recent work of Schweinsberg and Durrett on selective sweeps in the Moran model.
Cite
@article{arxiv.math/0503485,
title = {An approximate sampling formula under genetic hitchhiking},
author = {Alison Etheridge and Peter Pfaffelhuber and Anton Wakolbinger},
journal= {arXiv preprint arXiv:math/0503485},
year = {2007}
}
Comments
Published at http://dx.doi.org/10.1214/105051606000000114 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)